1,722,328 research outputs found
The race against time to disclose lung inflammation in interstitial lung disease in systemic sclerosis: is PET scan the winning solution?
No full textThe race against time to disclose lung inflammation in interstitial lung disease in systemic sclerosis: is PET scan the winning solution
Beyond Raynaud's phenomenon hides very early systemic sclerosis: the assessment of organ involvement is always mandatory
No full textUltrasound-integrated tight control in early psoriatic arthritis during adalimumab treatment
No full textContributo scientific
In response to: Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis
No full text..
From Raynaud's Phenomenon to Very Early Diagnosis of Systemic Sclerosis- The VEDOSS approach
No full textFrom Raynaud's Phenomenon to Very Early Diagnosis of Systemic Sclerosis- The VEDOSS approach
La riabilitazione multidisciplinare del malato reumatico
No full textpanoramica sulla sclerosi sistemic
Epigenetics and Systemic Sclerosis
No full textSystemic sclerosis (SSc) is a connective-tissue disease more frequent in women than in men. Genetics have been hypothesized to have a main role in disease susceptibility, but none of the genetic factors put forward is sufficient to induce the disease. Recently, exogenous factors and epigenetic modifications have been proposed to have a role in the determination of the disease phenotype. For example, fibrotic signal transduction pathways in SSc converge on DNA methylation and histone deacetylation at the FLI1 gene. In addition, regulation of the COL1A1 gene in fibroblasts involves transcription factors (hc-Krox, Sp1, Sp3) which upregulate COL1A1 transcriptional activity and provide evidence for a profibrotic role of hc-Krox. These findings provide novel insights into the epigenetic regulation of fibrosis. They may suggest that the drugs acting on epigenetic mechanisms may be useful as antifibrotic treatments in SSc. © 2009 John Wiley & Sons Ltd
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