1,747,329 research outputs found
Comparing Peptide Spectra Matches Across Search Engines
No full textMass spectrometry is extremely efficient for sequencing small peptides generated by, for example, a trypsin digestion of a complex mixture. Current instruments have the capacity to generate 50-100 K MSMS spectra from a single run. Of these ~30-50% is typically assigned to peptide matches on a 1% FDR threshold. The remaining spectra need more research to explain. We address here whether the 30-50% matched spectra provide consensus matches when using different database-dependent search pipelines. Although the majority of the spectra peptide assignments concur across search engines, our conclusion is that database-dependent search engines still require improvements.</p
Data Imputation in Merged Isobaric Labeling-Based Relative Quantification Datasets
No full textThe data-dependent acquisition in mass spectrometry-based proteomics combined with quantitative analysis using isobaric labeling (iTRAQ and TMT) inevitably introduces missing values in proteomic experiments where a number of LC-runs are combined, especially in the growing field of shotgun clinical proteomics, where the protein profiles from the proteomics analysis of several hundred patient samples are compared and correlated to clinical traits such as a specific disease or disease treatment in order to link specific outcomes to one or more proteins. In the context of clinical research it is evident that missing values in such datasets reduce the power of the downstream statistical analysis therefore may hampers the linking of the expression of disease traits to the expression of specific proteins that may be useful for prognostic, diagnostic, or predictive purposes. In our study, we tested three data imputation approaches initially developed for microarray data for the imputation of missing values in datasets that are generated by several runs of shotgun proteomic experiments and where the data were relative protein abundances based on isobaric tags (iTRAQ and TMT). Our conclusion is that imputation methods based on k Nearest Neighbors successfully impute missing values in datasets with up to 50% missing values.</p
Letter to M. D. Brouhard from John L. Matthiesen, June 25, 1951, with attached documents
No full textLetter to Mr. M. D. Brouhard, Editor, General Telephone Directory Co., from John L. Matthiesen, with attached documents, which are as follows: (1) Letter to Mr. John L. Matthiesen of John W. Graham and Company from M. D. Brouhard, (2) Essay regarding Father\u27s Day\u27s commercial history, (3) Note concerning Sonora Dodd and the commercial aspect of Father\u27s Day.https://digitalcommons.whitworth.edu/fathers-day-correspondence/1108/thumbnail.jp
Portrait of Franz Matthiesen.
No full textDigital ImagePhotograph owned by Maren Matthiesen, Coppet, Switzerland; copied by T. KrakauerFranz Matthiesen was born Catzenstein and was later Catzenstein-Matthieso
Ziehungs-Liste der von Hochfürstl. gnädigster Obervormundschaftl. Landes-Herrschaft allhier, den hiesigen Bürger und Uhrmacher Christian Matthiesen gnädigst verwilligten Lotterie, zwey sehr schönen und accuraten von ihme verfertigten Wand-Uhren.
No full textZIEHUNGS-LISTE DER VON HOCHFÜRSTL. GNÄDIGSTER OBERVORMUNDSCHAFTL. LANDES-HERRSCHAFT ALLHIER, DEN HIESIGEN BÜRGER UND UHRMACHER CHRISTIAN MATTHIESEN GNÄDIGST VERWILLIGTEN LOTTERIE, ZWEY SEHR SCHÖNEN UND ACCURATEN VON IHME VERFERTIGTEN WAND-UHREN.
Ziehungs-Liste der von Hochfürstl. gnädigster Obervormundschaftl. Landes-Herrschaft allhier, den hiesigen Bürger und Uhrmacher Christian Matthiesen gnädigst verwilligten Lotterie, zwey sehr schönen und accuraten von ihme verfertigten Wand-Uhren. ([1])
Titelseite ([1])
Den 14den Januar. 1755. Vormittags. (2)
Eod. Nachmittags. (5)
Continuirt den 15den Januar. Nachmittags (7
Portrait of Franz Matthiesen.
No full textDigital ImagePhotograph owned by Maren Matthiesen, Coppet, Switzerland; copied by T. KrakauerFranz Matthiesen was born Catzenstein and was later Catzenstein-Matthieso
Matthiesen, Cora
No full textFred Matthiesen - husbandhttps://stars.library.ucf.edu/cfm-ch-register-vol07/1110/thumbnail.jp
Matthiesen, Cora
No full textFred Matthiesen - husbandhttps://stars.library.ucf.edu/cfm-ch-memoranda-1925/1273/thumbnail.jp
David Krueger: Myths of the Rune Stone [Audio interview]
No full textVikings Visit Minnesota in 1362. Well, not really, but that’s a story that had significant purchase in early 20th century Minnesota. In 1898 a Swedish immigrant discovered a buried stone with runic letters and the date 1362. The archaic Scandinavian script described a fishing party that returned to its camp to find “10 men red with blood and dead.” The news of the apparent visitation of fourteenth century Scandinavians to the great state of Minnesota was enthusiastically received by their latter day heirs. With so many immigrants entering the United States, it was reassuring to learn that these norsemen had staked a claim to the United States more than 100 years before Columbus. Better yet, they had baptized the soil with their own blood, consecrating it as holy ground. As the authenticity of the “Kensington Rune Stone” came under question, supporters dismissed much of the evidence produced by pointy-headed academics in their ivory towers. Though the scientific consensus has clearly declared the stone a fake, books are still written “proving” its authenticity. In Myths of the Rune Stone: Viking Martyrs and the Birthplace of America (University of Minnesota Press, 2015), historian and religion scholar David Krueger investigates the century-long story arc of this cultural artifact. He explores the passion for the Rune Stone among Scandinavian and, later, Catholics, who were intent on establishing their rightful place in the American community. Beyond the history of the Rune Stone itself, Krueger’s work provides valuable insights on the history of immigrant communities and the ways they seek to blend their ancestral histories into a new and imagined cultural landscape. Readers will find the themes of Myths of the Rune Stone illuminating in this time of increased tension and inflammatory rhetoric surrounding immigration. Fred Rowland recorded this interview with David Krueger on November 9, 2016.Temple University. College of Liberal ArtsTemple University. LibrariesReligionLearning & Research ServicesAudacityAudacit
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