139,909 research outputs found

    [Letter from Burrows Matthews to T. N. Carswell - December 11, 1941]

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    A letter written to Mr. T. N. Carswell, Parramore Post No. 57, American Legion, Abilene, Texas, from Burrows Matthews, Editor, Buffalo Courier Express, dated December 11, 1941. Burrows Matthews defines Americanism

    Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein

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    The regulation of differentiation is particularly important in microbial eukaryotes that inhabit multiple environments. The parasite Trypanosoma brucei is an extreme example of this, requiring exquisite gene regulation during transmission from mammals to the tsetse fly vector. Unusually, trypanosomes rely almost exclusively on post-transcriptional mechanisms for regulated gene expression. Hence, RNA binding proteins are potentially of great significance in controlling stage-regulated processes. We have previously identified TbZFP1 as a trypanosome molecule transiently enriched during differentiation to tsetse midgut procyclic forms. This small protein (101 amino acids) contains the unusual CCCH zinc finger, an RNA binding motif. Here, we show that genetic ablation of TbZFP1 compromises repositioning of the mitochondrial genome, a specific event in the strictly regulated differentiation programme. Despite this, other events that occur both before and after this remain intact. Significantly, this phenotype correlates with the TbZFP1 expression profile during differentiation. This is the first genetic disruption of a developmental regulator in T. brucei. It demonstrates that programmed events in parasite development can be uncoupled at the molecular level. It also further supports the importance of CCCH proteins in key aspects of trypanosome cell function

    Matthews, N A, 3792514

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/402137Surname: MATTHEWS. Given Name(s) or Initials: N A. Military Service Number or Last Known Location: 3792514. Missing, Wounded and Prisoner of War Enquiry Card Index Number: SEA-4262.221783 Item: [2016.0049.34430] "Matthews, N A, 3792514

    Matthews, F N, WX17000

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/402186Surname: MATTHEWS. Given Name(s) or Initials: F N. Military Service Number or Last Known Location: WX17000. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 38589.221832 Item: [2016.0049.34479] "Matthews, F N, WX17000

    Leaus monteithi Matthews & Lawrence, 2015, sp. n.

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    Leaus monteithi sp. n. (Figs 5, 22, 25, 30, 34) Description. With the characteristics of the genus. Length 5.3 –6.0 mm, maximum width of prothorax 1.5–1.7 mm, width at humeri 1.9 –2.0 mm. Legs flavo-castaneous at bases and apices of femora and most of tibiae, otherwise fuscous. Prothorax with sides unevenly convex, widest at basal third, lateral carinae simple, disc with pair of low median tumosities on either side of depressed and glabrous median line, basally shallowly transversely depressed. Pterothorax. Elytra with strong basal tumosities and moderately deep transverse depression behind them. Abdomen. Ovipositor without gonostyli. Vaginal sclerite with wings anteriorly recurved. Aedeagal parameres simple. Larva unknown. Distribution. Northern NSW in open eucalypt forest, obtained by pyrethrum fogging of moss on a tree trunk by Geoff Monteith (QMBA), after whom the species is named. Type specimens: Holotype ♀: NSW: 30 o 29 ’ 42 ”S, 152 o 21 ’ 27 ” Point Lookout Rd, radar beacon, 1390m, 13–14 Nov 2008. G. Monteith. Pyrethrum, trees, open for. (QMBA T 228901). Paratypes: same data as holotype, 1 ♂, 1 sex not determined (QMBA), 2 ♀♀ in spirit COL 427 (ANIC)Published as part of Matthews, Eric G. & Lawrence, John F., 2015, Trachelostenini sensu novo: redescriptions of Trachelostenus Solier, Myrmecodema Gebien and Leaus Matthews & Lawrence, based on adults and larvae, and descriptions of three new species of Leaus (Coleoptera: Tenebrionidae), pp. 289-312 in Zootaxa 4020 (2) on page 310, DOI: 10.11646/zootaxa.4020.2.4, http://zenodo.org/record/23647

    Matthews, N

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    Leaus tropicalis Matthews & Lawrence, 2015, sp. n.

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    <i>Leaus tropicalis</i> sp. n. <p>(Figs 10, 20, 24, 28, 29, 35)</p> <p> <b>Description</b>. With the characteristics of the genus. Length 4.0– 4.5 mm, maximum width of prothorax 1.0– 1.2 mm, width at humeri 1.2–1.6 mm. <i>Prothorax</i> with sides evenly convex and lateral carinae strongly irregularly dentate, disc evenly convex. <i>Pterothorax</i>. Elytra slightly tumescent at bases. <i>Abdomen</i>: Ovipositor with terminal gonostyli. Vaginal sclerite with central keel partly divided into two blades, and lateral halberd-shaped wings separated from central keel by narrow membranes. Aedeagal parameres simple. Larva unknown.</p> <p> <b>Distribution</b>. <i>L. tropicalis</i> is found in three of the 17 generally recognised montane blocks in the Queensland Wet Tropics: the Carbine Tableland (A4), Atherton Tableland (A9) and Mount Bellenden Ker (A10) at altitudes of 1150–1500m. A4 and A10 are the areas of highest diversity and endemism, which have served as stable refugia for a long geological period (Bouchard <i>et al</i>. 2005).</p> <p> <b>Type specimens. Holotype</b> ♀: NE Q: 16o24’S x 145o13’E 3.5 km NNE Mt Spurgeon 16 Oct 1991 1330 m Monteith & Janetzki Pyrethrum, trees & rocks (QMBA T 228900). <b>Paratypes</b>: ♂, 17.28S 145.29E QLD, Longlands Gap BS1 1150m 1 Sept-2 Oct. 1995 L. Umback Malaise trap (ANIC); ♀ NEQ: 17o24’Sx 145o49’E, Bartle Frere top camp 1500m 29 Nov 1998 G. Monteith Pyrethrum trees, R.F.1978 (QMBA); ♀, 17.06S 145.36E QLD, Mt Haig GS1 1150m, 3 Jan.-4 Feb.1995, P. Zborowski, Malaise traps (ANIC).</p>Published as part of <i>Matthews, Eric G. & Lawrence, John F., 2015, Trachelostenini sensu novo: redescriptions of Trachelostenus Solier, Myrmecodema Gebien and Leaus Matthews & Lawrence, based on adults and larvae, and descriptions of three new species of Leaus (Coleoptera: Tenebrionidae), pp. 289-312 in Zootaxa 4020 (2)</i> on page 310, DOI: 10.11646/zootaxa.4020.2.4, <a href="http://zenodo.org/record/236475">http://zenodo.org/record/236475</a&gt

    Arctic regions 1907

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    Shows explorers' routes. Relief shown by spot heights, hachures and landform drawings. Depths shown by soundings and gradient tints. "Copyright, 1907, by the J. N. Matthews Co., Buffalo, N.Y." "Specimen map" -- printed at top of sheet. Includes 3 ancillary maps and text.Color1:14,000,00

    Reversible decreases in N-acetylaspartate after acute brain injury

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    N-Acetylaspartate (NAA), which constitutes the major proportion of the dominant resonance in proton MR spectra of brain, is localized in mature brain exclusively in neurons and neuronal processes. A decrease in NAA has been observed in many cerebral pathologies and has usually been interpreted as an index of irreversible neuronal loss. The authors report a follow-up study of six patients with acute brain damage (four from demyelinating lesion and two from mitochondrial encephalopathy with lactic acidosis and stroke-like episodes [MELAS]). All patients underwent serial MR spectroscopy examinations. The four patients with acute demyelinating lesions initially showed decreases in NAA in the centers of the lesions that ranged between 34-72% of values from homologous brain volumes in the other hemisphere. All four patients subsequently showed substantial recovery of NAA as their clinical status improved. The two patients with MELAS syndrome had large decreases of NAA signal (50% and 20% of normal values, respectively) from their occipital lobe lesions during the acute stroke-like episodes. After the acute phase of the illness a progressive increase of NAA in the same volumes was seen in both patients (to 76% and 60% of normal values, respectively). These results demonstrate that significant recovery of NAA can occur after acute brain damage. The potential contribution of reversible neuronal dysfunction (as well as neuronal loss) must be considered in the interpretation of decreases in the NAA resonance associated with acute brain pathology

    Arctic 1907

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    Shows explorers' routes. Relief shown by spot heights, hachures and landform drawings. Depths shown by soundings and gradient tints. "Copyright, 1907, by the J. N. Matthews Co., Buffalo, N.Y." "Specimen map" -- printed at top of sheet. Includes 3 ancillary maps and text.Arctic regions -- South Sound Region -- Franz Joseph Land -- Spitzbergen.Color1:14,000,00
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