2,534 research outputs found
Supplemental Material for Hibbins and Hahn, 2019
No full textThis fileset contains two files:1) Supplementary materials and methods for Hibbins & Hahn 2018 as a pdf.2) Whole-genome alignments for 161 strains of the wild yeast species Saccharomyces paradoxus, in multisample variant format. Methodology and detailed description of data is available from Leducq et al. 2016 (Nature Microbiology). Used for analysis by Hibbins & Hahn 2018
Wisdom and apocalyptic in the Gospel of Matthew : a comparative study with 1 Enoch and 4QInstruction
No full textRecent scholarship has demonstrated that Matthew's gospel has significantly developed
both sapiential and apocalyptic elements within its narrative. Little attention has been paid,
however, to the question of how these two features of Matthew's gospel might relate to one
another. It is this gap in scholarly literature that the present study is intended to fill, by means of a
comparative study with two other texts of mixed genre: 1 Enoch and 4Qlnstruction.
An examination of these texts demonstrates that each is marked by an inaugurated
eschatology, within which the revealing of wisdom to an elect group, defined in distinction to the
Jewish parent group, serves as the pivotal moment of inauguration. In addition, within
4Qlnstruction the idea is developed that possession of this revealed wisdom allows the remnant
to live in fidelity to the will of the Creator and to the patterns built-in to the original creation.
Thus, possession of revealed wisdom facilitates a recovery of creation.
These findings provide lines of enquiry that may be brought to Matthew. Three sections
of the gospel are examined (chapters 5-7; 11-12; 24-25). It is argued that Jesus is presented as an
eschatological figure who reveals wisdom to an elect group. This wisdom cannot be reduced to
great moral insight or interpretation of Torah, but is presented as prophetic revelation, happening
in eschatological time. It remains the case, however, that Matthew presents it as wisdom and
presents Jesus as a sage.
More tentatively, it is suggested that creation provides the patterns for the ethical
requirements of Jesus' wisdom, thus indicating that the idea of restored creation is also at work in
Matthew. The fall of the temple may also be connected in Matthew's narrative to such a
restoration, but again, the evidence for this is not clear
Asymptotic iteration method for solving Hahn difference equations
No full textHahn’s difference operator Dq;wf(x)=(f(qx + w) – f(x))/((q – 1)x + w), q ∈ (0, 1), w > 0,
x = w/(1 – q) is used to unify the recently established difference and q-asymptotic
iteration methods (DAIM, qAIM). The technique is applied to solve the second-order
linear Hahn difference equations. The necessary and sufficient conditions for
polynomial solutions are derived and examined for the (q;w)-hypergeometric
equation.Natural Sciences and Engineering Research Council of CanadaCanadian Network for Research and Innovation in Machining Technolog
Matthew’s Emmanuel Messiah: a paradigm of presence for god's people
No full textThe motif of divine presence is a clear phenomenon within the Gospel of Matthew. The modern critical means for assessing the ancient biblical text have multiplied to the point, some claim, of disparity. This study employs both narrative and redaction criticism in an attempt to respond authentically to the structural, historical and theological dimensions of Matthew's Gospel. This study begins with the presumption of the wholeness and integrity of Matthew's narrative, and assumes the gospel story to have an inherently dramatic structure which invites readers to inhabit imaginatively its narrative world and respond to its call. But since we are concerned with the role of both reader and author, this study also assumes a text with an historical author and context. The introduction focuses on the meta-critical dilemma facing New Testament students - what is the text and how do we read it? - and seeks some balance in terms of Krieger's analogy of the text as both window and mirror. Proposed is a narrative reading of Matthew's presence motif alongside a redaction critical assessment of it. In Chapter 2 the elements of narrative theory are introduced and relevant terms defined: the structure of narrative, the function of the narrator, points of view. Chapter 3 becomes an exercise in narrative reading, with Matthew's presence motif providing the focus, and the implied reader’s interaction with the story being predominant in interpretation. Characters, rhetorical devices, and points of view are discussed, to understand the motif's development throughout the story's progress. The thrust of Chapter 4 is thereafter to examine divine presence as a dominant motif within Matthew's most important literary context: the Jewish scriptures. Here the primary paradigms of divine presence provided by the Patriarchs, the Sinai experience, and the Davidic-Zion traditions are assessed. Chapter 5 follows with a more detailed examination of the OT "I am with you/God is with us" formula and its µeo' vµwv/ηuwv language, so strongly connected to Matthew's presence motif. Chapters 6-8 build on these investigations with a closer analysis of the three critical "presence passages" of Mt 1:23. 18:20 and 28:20. The passages and their contexts are probed from a redaction critical perspective, guided by the narrative investigation of Chapter 3, and the background from Chapters 4 and 5.The three major "presence passages" examined in Chapters 6-8 are also complimented by a number of secondary issues: worship, wisdom, the Spirit and the poor in Matthew, and their relation to Jesus' divine presence. These are discussed in Chapter 9. Chapter 10 summarizes and looks briefly at some implications. Matthew' presence motif proves to be an important element of the Gospel’s rhetorical design, redactional strategy and Christology. The presence of Jesus, the Emmanuel Messiah, exhibited in his risen authority, becomes the focus of his people's hopes and experiences in the post-Easter world. What the presence of Yahweh was to his people. Jesus now provides in a new paradigm for his people - his followers, the little ones, the poor and the marginalized, from all nations
Data from echolocation convergence study
No full textThe data in this folder accompany the publication:
Thomas GWC and Hahn MW. 2015 Determining the null model for detecting adaptive convergence from genomic data: a case study using echolocating mammals. Molecular Biology and Evolution.
The files in this repository are:
1.alignments:The 6,400 amino acid alignments (in fasta format) of the 9 mammals used in this study along with the ancestral states as inferred by PAML.
2.species_tree.nwkThe newick formatted species tree inferred from the original alignments with RAxML and average consensus. Internal nodes have been labeled to correspond with the labels of the ancestral state sequences from the alignments
Matthew Paris and Anglo-Saxon England : a thirteenth-century vision of the distant past.
No full textRegulatory Reform: Assessing the Government's Numbers
No full textThis paper provides the most comprehensive assessment to date of the costs and benefits of federal regulatory activities. The assessment, based on the government's own numbers, shows that the net benefits for final regulations promulgated from 1981 to mid-1996 approach a net present value of 280 billion if agencies rejected such regulations. Net benefits could also increase if agencies replace existing regulations with more efficient alternatives, or if agencies substantially improve regulatory programs. The efficiency of individual regulations varies by agency and by the type of risk the regulation is designed to reduce. Regulations from the Department of Transportation comprise over half of the total net benefits of final regulations, although they account for less than 10% of all regulations. The net benefits of regulations from the Environmental Protection Agency account for only about a third of total net benefits, primarily because of 19 Clean Air Act regulations with high net benefits, although two-thirds of all regulations are EPA regulations. On average, regulations that reduce cancer risk are less efficient than other social regulations, and EPA cancer regulations appear less efficient than other cancer regulations. Regulations that reduce the risk of car, fire, or work-related accidents are generally more efficient than regulations that reduce the risk of cancer and heart disease. The study also shows that the efficiency of regulations has not declined over time, as some scholars suggest. Furthermore, the introduction of formal regulatory oversight by the OMB does not appear to influence the cost-effectiveness of regulations. The paper shows that agency compliance with regulatory impact analysis requirements in Reagan's Executive Order 12291 and Clinton's Executive Order 12866, the basis for agency estimates of the costs and benefits of regulation, is usually superficial. As a result, the quality of such analyses is generally poor. Partly because of the poor quality of analyses, it appears that agencies do not often use the analyses to improve regulatory outcomes. If Congress and the White House are serious about regulatory reform, they must cooperate to enforce the regulatory impact analysis requirement. Successful enforcement requires high-level political support, statutory language requiring all agencies to adhere to established principles of economic analysis, and rigorous review of agency analyses by an independent entity. At this time, it is unclear whether law makers are willing to exert the political muscle necessary to achieve real reform.
Reconciliation, business achievement, the missing link
No full textThe content of this book will explain A For various reasons Europeans and Germans left their Homeland. B How they travelled in groups and individually. C How they landed in South Australia. D The Newcomers reception in a British colony. E The treatment they received in Australia. F What the Germans and Europeans achieved in Australia
Parallel selection on TRPV6 in human populations.
No full textWe identified and examined a candidate gene for local directional selection in Europeans, TRPV6, and conclude that selection has acted on standing genetic variation at this locus, creating parallel soft sweep events in humans. A novel modification of the extended haplotype homozygosity (EHH) test was utilized, which compares EHH for a single allele across populations, to investigate the signature of selection at TRPV6 and neighboring linked loci in published data sets for Europeans, Asians and African-Americans, as well as in newly-obtained sequence data for additional populations. We find that all non-African populations carry a signature of selection on the same haplotype at the TRPV6 locus. The selective footprints, however, are significantly differentiated between non-African populations and estimated to be younger than an ancestral population of non-Africans. The possibility of a single selection event occurring in an ancestral population of non-Africans was tested by simulations and rejected. The putatively-selected TRPV6 haplotype contains three candidate sites for functional differences, namely derived non-synonymous substitutions C157R, M378V and M681T. Potential functional differences between the ancestral and derived TRPV6 proteins were investigated by cloning the ancestral and derived forms, transfecting cell lines, and carrying out electrophysiology experiments via patch clamp analysis. No statistically-significant differences in biophysical channel function were found, although one property of the protein, namely Ca(2+) dependent inactivation, may show functionally relevant differences between the ancestral and derived forms. Although the reason for selection on this locus remains elusive, this is the first demonstration of a widespread parallel selection event acting on standing genetic variation in humans, and highlights the utility of between population EHH statistics
Independent stratum formation on the avian sex chromosomes reveals inter-chromosomal gene conversion and predominance of purifying selection on the w chromosome
No full textWe used a comparative approach spanning three species and 90 million years to study the evolutionary history of the avian sex chromosomes. Using whole transcriptomes, we assembled the largest cross-species dataset of W-linked coding content to date. Our results show that recombination suppression in large portions of the avian sex chromosomes has evolved independently, and that long-term sex chromosome divergence is consistent with repeated and independent inversions spreading progressively to restrict recombination. In contrast, over short-term periods we observe heterogeneous and locus specific divergence. We also uncover four instances of gene conversion between both highly diverged and recently evolved gametologs, suggesting a complex mosaic of recombination suppression across the sex chromosomes. Lastly, evidence from 16 gametologs reveal that the W chromosome is evolving with a significant contribution of purifying selection, consistent with previous findings that W-linked genes play an important role in encoding sex-specific fitness. This article is protected by copyright. All rights reserved
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