4,402 research outputs found
Fox (Matthew). Le Christ cosmique
No full textRousse-Lacordaire Jérôme. Fox (Matthew). Le Christ cosmique. In: Archives de sciences sociales des religions, n°92, 1995. L'islam en europe. p. 155
Fox (Matthew). Le Christ cosmique
No full textRousse-Lacordaire Jérôme. Fox (Matthew). Le Christ cosmique. In: Archives de sciences sociales des religions, n°92, 1995. L'islam en europe. p. 155
A new cascade of HIV care for the era of "treat all".
No full textMatthew Fox and Sydney Rosen discuss a cascade of HIV care adapted to WHO-recommended antiretroviral therapy irrespective of CD4 cell count
Fox (Matthew) Religion USA: an Inquiry into Religion and Culture by way of Time Magazine
No full textIsambert François-André. Fox (Matthew) Religion USA: an Inquiry into Religion and Culture by way of Time Magazine. In: Archives de sciences sociales des religions, n°36, 1973. p. 169
Fox (Matthew) Religion USA: an Inquiry into Religion and Culture by way of Time Magazine
No full textIsambert François-André. Fox (Matthew) Religion USA: an Inquiry into Religion and Culture by way of Time Magazine. In: Archives de sciences sociales des religions, n°36, 1973. p. 169
Sam fox trot
No full textGift of Dr. Mary Jane Esplen.Piano [instrumentation]C major [key]Ragtime piano solo [form/genre]Fox [illustration]Dedicated to Irving C. Perkins [dedication]W [engraver]Publisher's advertisement on back cover [note
Beauty for the Present: Mill, Arnold, Ruskin and Aesthetic Education
No full textThe present thesis examines the idea of aesthetic education of three eminent Victorians: John Stuart Mill, Matthew Arnold and John Ruskin. By focusing on the essence of what they meant with ‘the cultivation of the beautiful’ and, more importantly, the way their ideas of beauty informed their criticism of society, my study aims to contribute to our understanding of the idea of aesthetic education in the Victorian context and, further, to participate in a recent debate about the nature of beauty and aesthetic education.
Chapter One focuses on John Stuart Mill’s concept of ‘feeling’ in a series of essays. I will demonstrate how Mill’s idea of ‘aesthetic education’ was an ‘education of feelings,’ and moreover, how this idea was integrated into his literary criticism, his later critique of democratisation, his description of an ideal liberal society and even his own style of writing. Chapter Two contains a comparative study of Matthew Arnold and Friedrich Schiller. Through a rereading of Arnold, I will argue that his idea of aesthetic education is essentially Schillerian and that their resemblance consists primarily in their stress on the importance of aesthetic unity for modern life, which was becoming increasingly fragmentary and multitudinous. Chapter Three examines John Ruskin’s idea of aesthetic education and concentrates particularly on the cultivation of perception. Perception, as I shall show, was pivotal in Ruskin’s idea of aesthetic education. Just as what happened in Mill and Arnold, the emphasis on the education of seeing continued from his early writings well into his art and social criticisms. It not only differentiated him from his fellow art critics; the conviction that people should perceive with a pure heart also enabled him to link observation of artistic details with moral criticism of contemporary society and, thereby, to turn the cultivation of the beautiful into a moral-aesthetic experience
A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction
No full textBackground: The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal lamina that completely ensheaths each muscle fiber. Basal laminas in general are composed of four main types of glycosylated proteins: laminins, collagens IV, heparan sulfate proteoglycans and nidogens (entactins). The portion of the muscle fiber basal lamina that passes between the motor nerve terminal and postsynaptic membrane has been shown to bear distinct isoforms of the first three of these. For laminins and collagens IV, the proteins are deposited by the muscle; a synaptic proteoglycan, z-agrin, is deposited by the nerve. In each case, the synaptic isoform plays key roles in organizing the neuromuscular junction. Here, we analyze the fourth family, composed of nidogen-1 and -2.Results: In adult muscle, nidogen-1 is present throughout muscle fiber basal lamina, while nidogen- 2 is concentrated at synapses. Nidogen-2 is initially present throughout muscle basal lamina, but is lost from extrasynaptic regions during the first three postnatal weeks. Neuromuscular junctions in mutant mice lacking nidogen-2 appear normal at birth, but become topologically abnormal as they mature. Synaptic laminins, collagens IV and heparan sulfate proteoglycans persist in the absence of nidogen-2, suggesting the phenotype is not secondary to a general defect in the integrity of synaptic basal lamina. Further genetic studies suggest that synaptic localization of each of the four families of synaptic basal lamina components is independent of the other three.Conclusion: All four core components of the basal lamina have synaptically enriched isoforms. Together, they form a highly specialized synaptic cleft material. Individually, they play distinct roles in the formation, maturation and maintenance of the neuromuscular junction
Determinants and consequences of failure of linkage to antiretroviral therapy at primary care level in Blantyre, Malawi: a prospective cohort study.
No full textBACKGROUND: Poor rates of linkage from HIV diagnosis to ART initiation are a major barrier to universal coverage of ART in sub-Saharan Africa, with reasons for failure poorly understood. In the first study of this kind at primary care level, we investigated the pathway to care in the Malawian National Programme, one of the strongest in Africa. METHODS AND FINDINGS: A prospective cohort study was undertaken at two primary care clinics in Blantyre, Malawi. Newly diagnosed HIV-positive adults (>15 years) were followed for 6-months to assess completion of eligibility assessments, initiation of ART and death. Two hundred and eighty participants were followed for 82.6 patient-years. ART eligibility assessments were problematic: only 134 (47.9%) received same day WHO staging and 121 (53.2%) completed assessments by 6-months. Completion of CD4 measurement (stage 1/2 only) was 81/153 (52.9%). By 6-months, 87/280 (31.1%) had initiated ART with higher uptake in participants who were ART eligible (68/91, 74.7%), and among participants who received same-day staging (52/134 [38.8%] vs. 35/146 [24.0%] p = 0.007). Non-completion of ART eligibility assessments (adjusted hazard ratio: 0.11, 95% CI: 0.06-0.21) was associated with failure to initiate ART. Retention in pre-ART care for non-ART initiators was low (55/193 [28.5%]). Of the 15 (5.4%) deaths, 11 (73.3%) occurred after ART initiation. CONCLUSIONS: Although uptake of ART was high and prompt for patients with known eligibility, there was frequent failure to complete eligibility assessment and poor retention in pre-ART care. HIV care programmes should urgently evaluate the way patients are linked to ART. In particular, there is a critical need for simplified, same-day ART eligibility assessments, reduced requirements for hospital visits, and active defaulter follow-up
Spatiotemporal heterogeneity and bias in respiratory infection surveillance
No full textParameter estimation of respiratory infection surveillance dynamics commonly utilize data aggregated over space and time. However, estimates derived from aggregated data may fail to account for biologically meaningful spatiotemporal heterogeneity of effects or to identify where and when transmissions occur. This dissertation shows that high-resolution temporal and spatial data can improve our understanding of heterogeneity while producing more valid and precise estimates of transmission parameters (e.g., contagiousness), behavioral trends (e.g., face mask utilization), and intervention effects (e.g., at-home test distribution). In three projects, we evaluate spatiotemporal heterogeneity in the context of two major respiratory pathogens: Tuberculosis and SARSCoV-2.
First, in project one, we identify disease transmission hotspots from a tuberculosis case surveillance system in Greater Vitória, Brazil. Utilizing a human mobility model and recently developed method to quantify disease transmission, we overcome multiple methodological constraints that often obscure spatially and temporally accurate transmission measurements. We estimate that two cities in Greater Vitória, Vila Velha (reproductive number = 1.05, 95%CI: 1.03–1.07) and Vitória (reproductive number = 1.04, 95%CI: 1.02–1.06), help sustain tuberculosis transmission in the entire region and may be effective targets for intervention, while Cariacica (reproductive number = 0.95, 95%CI: 0.94–0.97) fell below the critical threshold of 1 required to sustain transmission alone.
Next, in project two, we utilize interrupted time series methods to estimate the effect of mask mandates on mask adherence using a nationally representative digital health survey on masking and a comprehensive database of pandemic-related government policies. The analysis focuses on improving previous attempts at measuring the effectiveness of mask mandates at the state level, by utilizing county-level exposure and outcome data. We find that mask mandates were associated with a large heterogeneity of effects, ranging from increasing masking approximately 8% in counties with low levels of prior masking to 1% or lower change in masking in places like the Northeast U.S. where masking levels were already high.
Last, in project three, we leverage the same nationally representative digital health survey to understand at-home testing patterns in the United States. We utilize two different economic measures of resource allocation and a regression model with autoregressive integrated moving average errors to examine if the Covidtests.gov government program reduced at-home testing inequities. We show that Covidtest.gov did increase at-home testing across all demographics; however, income-, geographic- and race-based disparities in at-home test utilization were heightened during periods when the program was active. Specifically, the regression results estimate that Theil’s T, an economic metric used here to measure at-home testing disparities, was 53% (95%CI: 6%–121%) higher for household income, 214% (95%CI: 86%–429%) higher for race, and 90% (95%CI: 23%–193%) higher for geography during Covidtest.gov dissemination periods. Disparities were not elevated for age.
Together, these three projects demonstrate the substantial role that high-resolution data can play in improving our understanding of respiratory infection surveillance and informing effective public health interventions
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