666 research outputs found
Supplemental material for Relationship between preoperative patient-reported outcomes and hospital length of stay: a prospective cohort study of general surgery patients in Vancouver, Canada
No full textSupplemental Material for Relationship between preoperative patient-reported outcomes and hospital length of stay: a prospective cohort study of general surgery patients in Vancouver, Canada by Jason Sutherland, Guiping Liu, Trafford Crump, Matthew Bair and Ahmer Karimuddin in Journal of Health Services Research & Policy</p
An Instance Model of Associative Inference
No full textJamieson, R. K., & Crump, M. J. C. (in press). An instance model of associative inference. American Journal of Psycholog
Ben Crump and Racialized Professionalism
No full text(Excerpt)
Benjamin “Ben” Crump is the country’s most influential civil rights lawyer. His advocacy led to the arrest and prosecution of George Zimmerman. He has represented the families of George Floyd and Breonna Taylor and many others, negotiating record-breaking settlements despite a body of civil rights precedent that is overwhelmingly pro-defendant. Crump is also a modern lawyer who uses press conferences and social media to advance his clients’ cause. To his clients, he is a lawyer, confidante, and friend. Yet, based on the way national media covers him, his significance isn’t always clear. When his work isn’t being erased, it’s downplayed. Articles that compare him to Thurgood Marshall spend an equal amount of time describing his attire.
At George Floyd’s funeral, the Reverend Al Sharpton referred to Crump as “black America’s attorney general, probably because we don’t feel like we have one.” Yet ever since, reporting on Crump omits the second part of Sharpton’s comment, diminishing Sharpton’s point about Crump’s role as public prosecutor on behalf of a community that the federal government arguably does not otherwise does not protect.
Before Ben Crump became the “go-to lawyer” for Black families seeking justice for the murders of their loved ones, before he became a press conference mainstay, he was a Florida-based personal injury lawyer. His national prominence is not the inevitable result of the traditional road to legal stardom, the sort that begins at an Ivy League law school, is followed by a judicial clerkship, and capped off by a coveted position in the Solicitor General’s office. Ben Crump is not that kind of lawyer. He is “a state-college-educated attorney with no establishment connections who has nevertheless become “one of the best-known lawyers in the United States.”
In a country that loves to mythologize rags-to-riches stories, Crump’s rise is fairy tale-worthy. As inspirational as he is to this author, Crump occupies a different place in the American consciousness than the likes of Neal Katyal and Paul Clement, lawyers just as famous but far less scrutinized for their professional choices. When the press reports on Crump, instead of expanding its understanding of what professionalism looks like, it catalogues Crump’s departures from the norm.
This Essay explores how Crump’s professional persona is racialized. It uses Leah Goodridge’s framing of legal professionalism as a racial construct to explore how Crump is unnecessarily othered. Following this Introduction, Part I describes Ben Crump’s professional trajectory, from personal injury lawyer to the lawyer who gets “the call” when a Black person is murdered by the police. Part II then describes how professionalism is constructed in such a way that undermines Crump’s importance. The Essay concludes by describing the consequences of othering and even erasing Ben Crump’s triumphs
Answering Questions with Data : Introductory Statistics for Psychology Students
No full text1. Why Statistics?2. Describing Data3. Correlation4. Probability, Sampling, and Estimation5. Foundations for inference6. t-Tests7. ANOVA8. Repeated Measures ANOVA9. Factorial ANOVA10. More on Factorial Designs11. Simulating Data12. Thinking about answering questions with Data13. GIFsThis is a free textbook teaching introductory statistics for undergraduates in Psychology. This textbook is part of a larger OER course package for teaching undergraduate statistics in Psychology, including this textbook, a lab manual, and a course website. All of the materials are free and copiable, with source code maintained in Github repositories
The Semantic Librarian: A Search Engine Built from Vector-Space Models of Semantics
No full textThe files in the project contain the R source code for running the Semantic Librarian Shiny app discussed in Aujla, Crump, Cook, Jamieson (Behavioral Research Methods).
A cloud version of the Shiny app is currently available here
http://semanticlibrarian.shinyapps.io/SemanticLibraria
Path to Actinorhodin:Regio- and Stereoselective Ketone Reduction by a Type II Polyketide Ketoreductase Revealed in Atomistic Detail
No full textABSTRACT: In type II polyketide synthases (PKSs), which typically biosynthesize several antibiotic and antitumor compounds, the substrate is a growing polyketide chain, shuttled between individual PKS enzymes whilst covalently tethered to an acyl carrier protein (ACP): this requires the ACP interacting with a series of different enzymes in succession. During biosynthesis of the antibiotic actinorhodin, produced by Streptomyces cœlicolor, one such key binding event is between an ACP carrying a 16-carbon octaketide chain (actACP) and a ketoreductase (actKR). Once the octaketide is bound inside actKR, it is likely cyclized between C7 and C12 and regioselective reduction of the ketone at C9 occurs: how these elegant chemical and conformational changes are controlled is not yet known. Here, we perform protein-protein docking, protein NMR, and extensive molecular dynamics simulations to reveal a probable mode of association between actACP and actKR; we obtain and analyze a detailed model of the C7-C12-cyclized octaketide within the actKR active site; and confirm this model through multiscale (QM/MM) reaction simulations of the key ketoreduction step. Molecular dynamics simulations show that the most thermodynamically stable cyclized octaketide isomer (7R,12R) also gives rise to the most reaction competent conformations for ketoreduction. Subsequent reaction simulations show that ketoreduction is stereoselective as well as regioselective, resulting in an S-alcohol. Our simulations further indicate several conserved residues that may be involved in selectivity of C7- 12 cyclization and C9 ketoreduction. Detailed insights obtained on ACP-based substrate presentation in type II PKSs can help design ACP-ketoreductase systems with altered regio- or stereoselectivity
Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from streptomyces rimosus
No full textType II polyketide synthases (PKSs) utilize a dedicated and essential acyl carrier protein (ACP) in the biosynthesis of a specific polyketide product. As part of our ongoing studies into the mechanisms and control of polyketide biosynthesis, we report the second structure of a polyketide synthase ACP. In this work, multidimensional, heteronuclear NMR was employed to investigate the structure and dynamics of the ACP involved in the biosynthesis of the commonly prescribed polyketide antibiotic, oxytetracycline (otc). An ensemble of 28 structures of the 95 amino acid otc ACP (9916Da) was computed by simulated annealing with the inclusion of 1132 experimental restraints. Atomic RMSDs about the mean structure for all 28 models is 0.66 Angstrom for backbone atoms, 1.15 Angstrom for all heavy atoms (both values calculated for the folded part of the protein (residues 3-80)), and 0.41 Angstrom for backbone atoms within secondary structure. Otc ACP adopts the typical right-handed, four-helix fold of currently known ACPs but with the addition of a 13-residue flexible C-terminus. A comparison of the global folds of all structurally characterized ACPs is described, illustrating that PKS ACPs show clear differences as well as similarities to FAS ACPs. N-15 relaxation experiments for the protein backbone also reveal that the long loop between helices I and II is flexible and helix II, a proposed site of protein-protein interactions, shows conformational exchange. The helices of the ACP form a rigid scaffold for the protein, but these are interspersed with an unusual proportion of flexible linker regions. <br/
Cognitive Illusions of Authorship Reveal Hierarchical Error Detection in Skilled Typists
No full textTouchy Typing
Even the most able typist makes errors, and
Logan and Crump
(p.
683
) have used this real-world task to probe for the existence of two error-detection mechanisms. They inserted errors into words that had been typed correctly by the subjects, and they corrected errors that had been made. By measuring implicit error detection as the slowing of movement just after an error had been committed and by eliciting explicit monitoring of errors by the output shown on the screen, they uncovered a double dissociation. Inserted errors did not lengthen the interval until the next letter was typed, but they were reported by the typist as errors; on the other hand, corrected errors did increase the interval, but were nevertheless claimed by the subjects as having been typed correctly.
</jats:p
Multi-parameter measurements using optical fibre long period gratings for indoor air quality monitoring
No full textData underlying the results presented and discussed in:Multi-parameter measurements using optical fibre long period gratings for indoor air quality monitoringJiri Hromadk, Sergiy Korposh, Matthew C. Partridge, Stephen W. James, Frank Davis, Derrick Crump, Ralph P. TatamPublished in Sensors and Actuators B 2017.(http://dx.doi.org/10.1016/j.snb.2016.12.050)Note that the description of the instrumentation and conditions pertinent to each file are detailed within the paper. The filenames correspond to the corresponding figure in the paper figure.</div
- …
