1,720,966 research outputs found
Reply: Innovative Management of Implant Infection and Exposure in ADM/Implant-Based Breast Reconstruction with Negative Pressure Wound Therapy
No full textEffects of Propionyl-Carnitine in Patients with type2 diabetes and peripheral vascular disease
No full textEffects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial.
Ragozzino G, Mattera E, Madrid E, Salomone P, Fasano C, Gioia F, Acerra G, del Guercio R, Federico P.
SourceDepartment of Internal Medicine, Clinical Methodology and Medical Angiology, Second University of Naples, Italy. [email protected]
Abstract
OBJECTIVE: To assess the efficacy of propionyl-carnitine (PC) in patients with type 2 diabetes and peripheral arterial disease (PAD).
PATIENTS AND METHODS: This was an open pharmacodynamic study. Twenty-four obese patients with type 2 diabetes and PAD (stage IIb) were enrolled in the study. After an initial run-in period of 7 days on a low-calorie diet (1600 +/- 150 kcal/day), patients received intravenous PC (600mg in 100mL saline solution Na/K 0.9%) twice daily for 10 days (T1).
RESULTS: Treatment with PC produced statistically significant increases in maximal walking distance (30%; p < 0.05) and initial claudication distance (15%; p < 0.05) in 15 and eight patients, respectively. In addition, a decrease in dosage of oral antihyperglycaemic agents was observed in 21 patients at T1. No PC-related adverse effects were reported.
CONCLUSIONS: This study showed that acute intravenous administration of PC in patients with type 2 diabetes with PAD improved PAD-related symptoms as well as glycaemic control
Innovative Management of Implant Exposure in ADM/Implant-Based Breast Reconstruction with Negative Pressure Wound Therapy
No full textOne-stage implant-based breast reconstruction has been recently improved by the introduction of biological [acellular dermal matrix (ADM)] and synthetic meshes. Advantages of ADMs in implant-based breast reconstruction derive from the expansion of the space available for the direct positioning of an implant, but their use could be associated with several complications. Although the majority of complications can be easily managed, mistakes in dealing with the first clinical signs of a potential adverse event can lead to implant loss
New method for bacterial load measurement during hydro-debridement of cutaneous ulcer
No full textNew method for bacterial load measurement during hydro-debridement of cutaneous ulcer.
Apperti M, Di Lucia A, Goffredi L, Federico P, Mattera E, Masella A, Della Rocca MD, Apperti S.
SourceSeconda Università degli Studi di Napoli, Dipartimento di Scienze Anestesiologiche, Chirurgiche e dell'Emergenza.
Abstract
AIM OF THE STUDY: Based on their experience using Versajet for debridement of chronic wounds, the Authors set up a study protocol to verify whether the hydro-surgical cleansing could offer the possibility of taking tissue specimens suitable for diagnostic microbiological evaluation. The aims of the study were the following:
MAIN PURPOSE: To evaluate the efficacy of hydro-surgery in detecting the presence of microorganisms and measuring their load, as an alternative to conventional tissue sampling methods; SECONDARY PURPOSE: To set up an easier and less invasive diagnostic modality than surgical biopsy, even though likewise significant.
RESULTS: The results of this study show that tissue specimen collection by hydro-aspiration using Versajet is comparable to biopsy sampling (and in some cases it can be even more reliable); moreover, it is not more time-consuming and is certainly less invasive. Compared to surgical biopsy, with such a method a greater amount of tissue may be collected; moreover, tissue specimens can be taken from a broader surface or, depending on the needs, from a more focused area on the margin or at the bottom of the woun
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