45 research outputs found
Software and Control Architectures for Autonomous and Racing Vehicles
Get PDFThis work presents the achievements that have been obtained in a number of ongoing research projects, at the University of Padova, in the field of automotive software and control architectures.
An overview of current state-of-the-art algorithms for the various elements of an autonomous vehicle will be given, along with a discussion at the current software options available for designing such a complex device. To fully understand the choices that have been made during the development, it will be necessary to show also a number of technical implementation details; these provide interesting insight into the background work which is nowadays considered as given by anybody who is not a middleware developer.
On the other end of the automotive electronics spectrum, a data logger and co-processor for racing vehicles will be presented. This compact device required interdisciplinary design decisions in both the mechanical, electronics and software engineering fields. Despite being a radically different application, a few key convergence points will emerge from the discussion.
The activity behind these projects covers several issues of applied research within the information technology tradition, and paves the way for the experimentation on live devices, with all their not-really-ideal behaviors, of advanced algorithms
in the automotive fields at the University of Padova
Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence
No full textAbstract An important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and alter the microenvironment. Transcription of endogenous retroviruses (ERVs) is also a consequence of this epigenetic switch. In this manuscript, we have identified a group of ERVs that are epigenetically silenced in proliferating cells but are upregulated during replicative senescence or during various forms of oncogene-induced senescence, by RAS and Akt, or after HDAC4 depletion. In a HDAC4 model of senescence, removal of the repressive histone mark H3K27me3 is the plausible mechanism that allows the transcription of intergenic ERVs during senescence. We have shown that ERVs contribute to the accumulation of dsRNAs in senescence, which can initiate the antiviral response via the IFIH1-MAVS signaling pathway and thus contribute to the maintenance of senescence. This pathway, and MAVS in particular, plays an active role in shaping the microenvironment and maintaining growth arrest, two essential features of the senescence program
Cardiac Magnetic Resonance Feature-Tracking Identifies Preclinical Abnormalities in Hypertrophic Cardiomyopathy Sarcomere Gene Mutation Carriers
Get PDFBackground: Assessing myocardial strain by cardiac magnetic resonance feature tracking (FT) has been found to be useful in patients with overt hypertrophic cardiomyopathy (HCM). Little is known, however, of its role in sarcomere gene mutation carriers without overt left ventricular hypertrophy (subclinical HCM). Methods: Thirty-eight subclinical HCM subjects and 42 healthy volunteers were enrolled in this multicenter case-control study. They underwent a comprehensive cardiac magnetic resonance study. Two-dimensional global radial, circumferential, and longitudinal strain of the left ventricle (LV) were evaluated by FT analysis. Results: The subclinical HCM sample was 41 (22-51) years old and 32% were men. FT analysis revealed a reduction in global radial strain (29±7.2 versus 47.9±7.4; P<0.0001), global circumferential strain (-17.3±2.6 -versus -20.8±7.4; P<0.0001) and global longitudinal strain (-16.9±2.4 versus -20.5±2.6; P<0.0001) in subclinical HCM compared with control subjects. The significant differences persisted when considering the 23 individuals free of all the structural and functional ECG and cardiac magnetic resonance abnormalities previously described. Receiver operating characteristic curve analyses showed that the differential diagnostic performances of FT in discriminating subclinical HCM from normal subjects were good to excellent (global radial strain with optimal cut-off value of 40.43%: AUC, 0.946 [95% CI, 0.93-1.00]; sensitivity 90.48%, specificity 94.44%; global circumferential strain with cut-off, -18.54%: AUC, 0.849 [95% CI, 0.76-0.94]; sensitivity, 88.10%; specificity, 72.22%; global longitudinal strain with cut-off, -19.06%: AUC, 0.843 [95% CI, 0.76-0.93]; sensitivity, 78.57%; specificity, 78.95%). Similar values were found for discriminating those subclinical HCM subjects without other phenotypic abnormalities from healthy volunteers (global radial strain with optimal cut-off 40.43%: AUC, 0.966 [95% CI, 0.92-1.00]; sensitivity, 90.48%; specificity, 95.45%; global circumferential strain with cut-off, -18.44%: AUC, 0.866 [95% CI, 0.76-0.96]; sensitivity, 92.86%; specificity, 77.27%; global longitudinal strain with cut-off, -17.32%: AUC, 0.838 [95% CI, 0.73-0.94]; sensitivity, 90.48%; specificity, 65.22%). Conclusions: Cardiac magnetic resonance FT-derived parameters are consistently lower in subclinical patients with HCM, and they could emerge as a good tool for discovering the disease during a preclinical phase
Validation of the ejection fraction-velocity ratio: a new simplified “function-corrected” index for assessing aortic stenosis severity
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Slovenščina in furlanščina: poskus primerjave jezikovnega načrtovanja/Sloveno e friulano: un tentativo di confronto della pianificazione linguistica
No full textIn base alle osservazioni rivolte alle linee generali di pianificazione linguistica attuate nella Regione autonoma Friuli Venezia Giulia, si compie un tentativo di confrontare, ove pos- sibile, i settori di intervento dello sloveno e del friulano, in particolare nell’ambito dell’e- ducazione. Lo spazio geografico di riferimento è, nello specifico, la provincia di Udine. Nel contributo si procede innanzi tutto alla valutazione di determinati contenuti e princi- pi espressi nei testi legislativi specifici che permetterebbero di comprendere le potenzialità di un’eventuale politica anche nell’ottica del pluralismo linguistico. In seguito si cerca di individuare gli organi principali che emanano le disposizioni in materia di pianificazione linguistica, gli strumenti e le modalità di messa in opera della stessa, mettendo in evidenza alcune importanti esperienze.
Poiché i principi espressi dagli strumenti di tutela, che richiamano la normativa statale, euro- pea e internazionale in materia, permetterebbero un livello di sviluppo elevato della condizio- ne linguistica delle comunità interessate, l’autore mette a disposizione alcuni dati che mettono in luce la discrepanza tra il livello dichiarativo o programmatico della politica linguistica e lo stato reale. In questo senso si accenna anche al ruolo svolto diffusamente dal dissenso espresso in atteggiamenti, opinioni e ideologie che ostacolano la libertà di esercitare o di ampliare, secondo le aspirazioni dei parlanti, il diritto di usare nella vita sociale le lingue altre.
According to the observation made of the general lines of language planning, implemented in the Autonomous Region of Friuli Venezia Giulia, the author makes an attempt to compare, where possible, the areas of Slovenian and Friulan intervention, particularly in the field of education. The geographical space of reference is, specifically, the province of Udine.
He proceeds firstly to the evaluation of certain contents and principles, expressed in specific legislation, that would allow to understand the potential of any policy, also in the perspective of the interaction and linguistic pluralism. He tries then to identify the major organs that enact the regulations on language planning, as well as the tools and the procedures for its implementation, also by emphasizing some important experiences. Since the principles expressed by the means of protection, which recall the state, European and international legislation, would allow a high level of development of the linguistic condition of the concerned communities, the author provides some data which highlight the discrepancy between the declarative or programmatic level of language policy and the real state. In this sense, he also hints at the role played by the widespread disagreement expressed in attitudes, opinions and ideologies that hinder the freedom to exercise or to expand, according to the aspirations of the speakers, the right to use in social life the different languages
Influence of Variable Loading Conditions on Pulsed Doppler Indices of Left Ventricular Ejection Dynamics
No full textResponses of European economic cultures to Europe's crisis politics : the example of German-Italian discrepancies
No full textWhen we started our preparation for this project only a year ago, our prime concerns were the deepening of the social and economic asymmetries between the North and the South under the impact of the financial crisis, with Germany and Italy providing an example of existential importance for the EU as a whole. Both of us had resided in the two countries for prolonged periods in the past, and we had never witnessed such a surge in antagonistic feelings on both sides of the Alps as occurred during the Euro crisis. This can even be measured: while it had been common in Germany, at the beginning of the crisis, to talk about the PIIGS states (Portugal, Ireland, Italy, Greece and Spain), with Italy figuring among them as an important member, the percentage of Italians having a positive image of Germany crashed only from 75 to 65 per cent during the immediate crisis period, and now the majority of the Italians thinks that Germany has too much influence in Europe and that it uses this influence at the expense of Southern Member States. While our application for funding was still pending, we witnessed two crucial events that increased the pertinence of our project way beyond our expectations. First, on the 24 September 2017, for the first time in post-war German history, a far right party entered the German Bundestag with a landslide victory, receiving 14 per cent of the popular vote and 100 parliamentary seats. Second, only five months later in Italy, the far-right Lega party and the Movimento Cinque Stelle emerged as the big winners from the Italian federal elections of the 4th of March 2018. Forming a previously unthinkable coalition between right-wing and left-wing populism, they entered into government. We are not so naïve as to believe that the variety of Europe’s crises could be understood and adequately analysed as though these were isolated events. The course of Italy’s economic and social policy has so obviously been affected by the migration burdens that Italy has had to shoulder and the lack of European solidarity; the bitter disappointment could be turned into populist critique of the constraints that European rule imposes upon national policies and the public announcement of disobedience by members of the Italian government. In a similar vein, the Alternative für Deutschland (AfD) in Germany had been founded as an anti-Euro rescue party, which catalysed quickly through the immigration crisis of 2015 into a xenophobic far-right populist party, sharing many positions with the Italian Lega. While the parties and alliances in both countries had capitalised very much upon the antagonisms between Italy and Germany and their positions during the Euro crisis by building on nationalist sentiments, today we have reached a true anti-climax when one observes that the intensification of tensions are accompanied by the founding of new alliances and a contagion towards formerly non-populist and non-far right parties in both countries: “Europe does not want migrants, it wants our money” (Luigi Di Maio); “Migration is the Mother of all problems” (Horst Seehofer). Both the AfD in Germany and the Lega in Italy share two major targets against which they direct their rage: European integration, especially in the economic realm, and immigration. We refrain, however, from attempting to disentangle all these interdependencies, but hope that our study of the two exemplary cases of Italy and Germany will provide us with some answers to the question of what led us down this road. We believe that the approach which we have pursued in our design of this project provides illuminating insights of lasting importance.Acknowledgements 6 ;Introductory Explanations 6; Contributors 20; A) The Political Economy of Germany and Italy;The German Political Economy under the Euro – and a Comparison to the “Southern Model” - Philip Manow 27; The Political Economy of Public Sector Wage-setting in Germany and Italy - Donato Di Carlo 48;Geo-Politics of Exporting Too Much: Contrasting Trajectories of Germany and Japan - Margarita Estévez-Abe 63; Ideational Differences between Italian and German Governments during the Crisis -Frederico Bruno 74; A Cultural Political Economy Approach to the European Crisis - Josef Hien 80; B) Sectors of the Political Economy of Italy and Germany;Worlds Apart: The Divergence of Southern-European Housing-Construction Economies and Northern European Export Economies - Sebastian Kohl & Alexander Spielau 99;Banking Crisis Interventions in Germany and Italy: the Unpleasant Case of the New European Bank Resolution Framework -Frederik Traut 108;Comparing the German and Italian Approaches to Banking Union - Lucia Quaglia 120; Maternal employment, attitudes toward gender equality and work-family policies. German-Italian Discrepancies? - Agnes Blome 129;C) German and Italian Perceptions, Differences and Misgivings;Italy and Germany during the Crisis: Support for the EU and Reciprocal Views - Alessandro Pellegata 140;The Political Space in Italy and Germany during the Crisis: Italian and German Populism Compared - Hanspeter Kriesi148;The political economy of recovery in Southern Europe - Manos Matsaganis 157;Accommodating EU‘s influence vs protecting national sovereignty. - Ilaria Madama and Matteo Jessoula 162; European Integration and Political Ownership: Fiction and Reality behind Structural Reforms and Risk-Sharing - Filippo Taddei 170;D) The Legacy of the Welfare State in Europe;An Alternative to the Constitution of the EU’s Single Market? - Florian Rödl 176; Industrial Relations and Labour Law in the EU Economic Governance Mechanisms:The Cases of Italy and Germany - Francesco Costamagna 182; What to expect from Germany for the European Pillar of Social Rights and beyond? - Marcel Hadeed 188; The EU Political Culture of Total Optimism is not Dead: Reflections on the European Pillar of Social Rights - Vladimir Bogoeski 196;A ‘more political’ leadership for the President of the Commission? A mixed-methods language-based analysis -Pamela Pansardi 201;E) The Demise of Law; The EU as “Honest Broker”? German and Italian Perspectives on an Adminstrative Body -Anna Katharina Mangold 215; Integration-through-crisis as a distinct integrative mode: Placing expediency ahead of democracy? - Nicole Scicluna 220; Should the Specifics of National Political Cultures be Characterised as “Democratic Acquis” and Can they be Defended by Law? Beyond the Nostalgia-Controversy between JÜrgen Habermas and Wolfgang Streeck -Christian Joerges 229; The End of the Universality of Norms as a Model for Europe: The Error of “Seeing like a State” (J.S. Scott) in the Postmodern Condition - Karl-Heinz Ladeur 237; F) Justice Deficits and Solidarity; Is the EU Unjust? - Glyn Morgan 244; A European Minister of Economy and Finance:Assessing the Commission’s proposal and Comparing the Positions of Germany and Italy - Tiziano Zgaga 253; Re-solidarizing Europe and Defusing the Crisis - Maurizio Ferrera and Carlo Burelli 263; Summarising Comments; Concluding Remarks: Economic Cultures and the Politics of Interdependence - Visnja Vukov 269; Two Annexes; Order in the Eurozone: Maurizio Ferrera and Claus Offe in Conversation - Maurizio Ferrera and Claus Offe 278; Germany is Quietly Rebalancing its Economy – But This will not Fix the Eurozone’s Flaws - Donato Di Carlo 282
Very high energy observations of the Seyfert galaxy NGC 4151 with MAGIC Indication of another gamma-ray obscured candidate neutrino source
No full textAbe, K. et al.--Full list of authors: Abe, K.; Abe, S.; Abhir, J.; Abhishek, A.; Acciari, V. A.; Aguasca-Cabot, A.; Agudo, I.; Aniello, T.; Ansoldi, S.; Antonelli, L. A.; Arbet Engels, A.; Arcaro, C.; Arnesen, T. T. H.; Asano, K.; Babić, A.; Bakshi, C.; Barres de Almeida, U.; Barrio, J. A.; Barrios-Jiménez, L.; Batković, I.; Baxter, J.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Bernete, J.; Berti, A.; Besenrieder, J.; Bigongiari, C.; Biland, A.; Blanch, O.; Bonnoli, G.; Bošnjak, Ž.; Bronzini, E.; Burelli, I.; Campoy-Ordaz, A.; Carosi, A.; Carosi, R.; Carretero-Castrillo, M.; Castro-Tirado, A. J.; Cerasole, D.; Ceribella, G.; Chai, Y.; Cifuentes, A.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; de Menezes, R.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Di Pierro, F.; Di Tria, R.; Di Venere, L.; Dinesh, A.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Eisenberger, L.; Elsaesser, D.; Escudero, J.; Fariña, L.; Foffano, L.; Font, L.; Fröse, S.; Fukazawa, Y.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giesbrecht Paiva, J. G.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Gradetzke, T.; Grau, R.; Green, D.; Green, J. G.; Günther, P.; Hadasch, D.; Hahn, A.; Hassan, T.; Heckmann, L.; Herrera Llorente, J.; Hrupec, D.; Imazawa, R.; Israyelyan, D.; Jahanvi, J.; Jiménez Martínez, I.; Jiménez Quiles, J.; Jormanainen, J.; Kankkunen, S.; Kayanoki, T.; Konrad, J.; Kouch, P. M.; Kubo, H.; Kushida, J.; Láinez, M.; Lamastra, A.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Lulić, L.; Lyard, E.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mangano, S.; Mannheim, K.; Marchesi, S.; Mariotti, M.; Martínez, M.; Maruševec, P.; Mas-Aguilar, A.; Mazin, D.; Menchiari, S.; Méndez Gallego, J.; Menon, S.; Miceli, D.; Miranda, J. M.; Mirzoyan, R.; Molero González, M.; Molina, E.; Mondal, H. A.; Moralejo, A.; Nakamori, T.; Nanci, C.; Neustroev, V.; Nickel, L.; Nievas Rosillo, M.; Nigro, C.; Nikolić, L.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Okumura, A.; Otero-Santos, J.; Paiano, S.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Peresano, M.; Persic, M.; Pihet, M.; Pirola, G.; Podobnik, F.; Prada Moroni, P. G.; Prandini, E.; Rhode, W.; Ribó, M.; Rico, J.; Sahakyan, N.; Saito, T.; Saturni, F. G.; Schmitz, K.; Schmuckermaier, F.; Schubert, J. L.; Schweizer, T.; Sciaccaluga, A.; Silvestri, G.; Simongini, A.; Sitarek, J.; Sliusar, V.; Sobczynska, D.; Stamerra, A.; Strišković, J.; Strom, D.; Strzys, M.; Suda, Y.; Tajima, H.; Takahashi, M.; Takeishi, R.; Temnikov, P.; Terauchi, K.; Terzić, T.; Teshima, M.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vazquez Acosta, M.; Ventura, S.; Verna, G.; Viale, I.; Vigliano, A.; Vigorito, C. F.; Visentin, E.; Vitale, V.; Vovk, I.; Walter, R.; Wersig, F.; Will, M.; Yamamoto, T.; Yeung, P. K. H.; Neronov, A.; Peretti, E.; Peron, G.Seyfert galaxies are emerging as a promising source class of high-energy neutrinos. The Seyfert galaxies NGC 4151 and NGC 1068 have respectively come up as the most promising counterparts of a 3σ and of a 4.2σ neutrino excesses detected by IceCube in the TeV energy range. Constraining the very high energy (VHE) emission associated with the neutrino signal is crucial to unveiling the mechanism and site of neutrino production. In this work, we present the first results of the VHE observations (∼29 hours) of NGC 4151 with the MAGIC telescopes. We detected no gamma-ray excess in the direction of NGC 4151, and we derived constraining upper limits on the VHE gamma-ray flux. The integral flux upper limit (at the 95% confidence level) above 200 GeV is f = 2.3 × 10−12 cm−2 s−1. Comparison of the MAGIC and IceCube measurements suggests the presence of a gamma-ray obscured accelerator, and it allowed us to constrain the gamma-ray optical depth and the size of the neutrino production site. © The Authors 2025.We would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the grants PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-104114RB-C33, PID2019-105510GB-C31, PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22, PID2022-136828NB-C41, PID2022-137810NB-C22, PID2022-138172NB-C41, PID2022-138172NB-C42, PID2022-138172NB-C43, PID2022-139117NB-C41, PID2022-139117NB-C42, PID2022-139117NB-C43, PID2022-139117NB-C44 funded by the Spanish MCIN/AEI/ 10.13039/501100011033 and “ERDF A way of making Europe”; the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-400/18.12.2020 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also been supported by Centros de Excelencia “Severo Ochoa” y Unidades “María de Maeztu” program of the Spanish MCIN/AEI/ 10.13039/501100011033 (CEX2019-000920-S, CEX2019-000918-M, CEX2021-001131-S) and by the CERCA institution and grants 2021SGR00426 and 2021SGR00773 of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2022-10-4595 and the University of Rijeka Project uniri-prirod-18-48; by the Deutsche Forschungsgemeinschaft (SFB1491) and by the Lamarr-Institute for Machine Learning and Artificial Intelligence; by the Polish Ministry Of Education and Science grant No. 2021/WK/08; by the Brazilian MCTIC, the CNPq Productivity Grant 309053/2022-6 and FAPERJ Grants E-26/200.532/2023 and E-26/211.342/2021. E.P. was supported by Agence Nationale de la Recherche (grant ANR-21-CE31-0028) and by INAF through “Assegni di ricerca per progetti di ricerca relativi a CTA e precursori”. Author Contributions. A. Lamastra: project management, P.I. of MAGIC observations, MAGIC data analysis, theoretical interpretation, paper drafting; S. Mangano: MAGIC analysis cross-check, paper drafting; S. Menon: MAGIC data analysis, paper drafting; E. Peretti: P.I. theory, theoretical modeling and interpretation, paper drafting; G. Peron: Fermi-LAT data interpretation and paper drafting; F. G. Saturni: theoretical interpretation and paper drafting. The rest of the authors have contributed in one or several of the following ways: design, construction, maintenance and operation of the instrument(s) used to acquire the data; preparation and/or evaluation of the observation proposals; data acquisition, processing, calibration and/or reduction; production of analysis tools and/or related Monte Carlo simulations; overall discussions about the contents of the draft, as well as related refinements in the descriptions.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000918-M).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).Peer reviewe
