86,563 research outputs found
An Investigation on the students’ Learning Styles in an Advanced Applied Mechanics Course
No full textIn this paper, an application of Multiple Intelligence Theory (M.I.) to the analysis of some adult students' learning characteristics is presented. The investigation is conducted over a group of students enrolled at the level of a graduate course in Aerospace Engineering of the University of Rome La Sapienza. Results allow students to better understand their own characteristics in learning, and help teachers in tuning up the adopted didactical methods. The investigation offers the possibility of acquiring a comparison learning profile to be used during freshmen candidates' orientation
Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE
No full textDiazepam is frequently used as an adjuvant during antidepressant therapy. Recently, some studies have suggested that the treatment with benzodiazepines could have different efficacy in depressed patients as opposed to non-depressed ones. To clarify the matter, a study is currently underway, regarding the drug metabolism in rats. In order to obtain a more complete and significant set of data, the main diazepam metabolites have also been considered, namely: nordiazepam, temazepam and oxazepam. A feasible and reliable HPLC method has been developed for the simultaneous determination of these compounds in plasma and brain tissue of rats. The method has been applied to "normal" rats and to genetic rat models of depression in order to estimate drug metabolism in different breeds. Analyte separation was achieved on a C8 reversed phase column using an acidic phosphate buffer/acetonitrile mixture as the mobile phase. The detection wavelength was 238 nm. An original sample pre-treatment, based on solid-phase extraction (SPE) was developed in order to eliminate endogenous interference, using only 250 μL of matrix (brain homogenate or plasma) for a complete analysis. The method has been validated with good results in terms of precision, extraction yield, sensitivity, selectivity and accuracy on both matrices and has been successfully applied to samples from some rats subjected to the preliminary study. The obtained data will hopefully contribute to the clarification of possible differences between depressed and non-depressed subjects with respect to benzodiazepine biotransformation. © 2009 Elsevier B.V. All rights reserved
Innovative analysis of diazepam and metabolites in rat brain and plasma using an original MEPS – HPLC method
No full textDiazepam (7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) is one of the most widely used anxiolytic-hypnotic drugs. It is a long-acting benzodiazepine with anxiolytic, sedative, hypnotic, anticonvulsant, muscle relaxant and amnestic properties. Diazepam is also frequently used for the relief of anxiety during the first period of treatment with selective serotonin reuptake inhibitors (SSRIs) and generally as a coadjuvant during antidepressive therapy. Recently, some studies have suggested that the treatment with benzodiazepines could have different efficacy in depressed patients as opposed to non-depressed ones. In order to clarify the matter, some studies are currently underway, regarding the drug metabolism in rats. In order to obtain a more complete and significative set of data, the main diazepam metabolites have also been considered, namely: nordiazepam, temazepam and oxazepam, which are the demethylated, hydroxylated and demethylated hydroxylated analogues of diazepam, respectively. All of these compounds are pharmacologically active, have a long half-life and thus significantly contribute to the therapeutic effects of diazepam administration. Their determination can also give important insight into the respective balance of different metabolic pathways. Following our recent studies on benzodiazepine determination, we are developing a feasible and reliable HPLC method for the simultaneous determination of diazepam and its three main metabolites in rat brain and plasma. The method will be applied to “normal” rats and to genetic rat models of depression in order to estimate the drug metabolism in the different breeds. Analyte separation was achieved on a C8 reversed phase column using an acidic phosphate buffer / acetonitrile mixture as the mobile phase. The detection wavelength is 238 nm. An accurate and innovative sample pre-treatment, based on microextraction by packed sorbent (MEPS) was developed in order to suitably eliminate endogenous interferences, using only 250 μL of matrix (brain homogenate or plasma) for a complete analysis. The analytes are eluted from the cartridge with methanol; the eluate is then dried under vacuum and redissolved in the mobile phase. The results obtained with the MEPS procedure were confirmed by comparison with those obtained with a solid-phase extraction (SPE) procedure. The method has been validated with good results in terms of precision, extraction yield, accuracy, sensitivity and selectivity on both matrices and the determination of diazepam and metabolite levels in rats is currently under way. The results obtained until now are satisfactory form an analytical point of view and will hopefully contribute to the clarification of some metabolic differences between depressed and non-depressed subjects with respect to benzodiazepine biotransformation
Metabotropic glutamate (mGlu) 2/3 receptors and depressive disorder: New pharmacological targets to shorten the clinical latency of antidepressant drugs and potential involvement the pathophysiology of depression
No full textVariations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
L’autodeterminazione del paziente tra relazionalità e autonomia
No full textIl saggio individua nell'autodeterminazione del paziente il filo rosso attraverso il quale è possibile ricostruire la storia e l'evoluzione dei comitati etici. In Italia l’approvazione delle «Norme in materia di consenso informato e di disposizioni anticipate di trattamento» (lex 219 2017) ha portato ad un pieno riconoscimento della saldatura tra il diritto alla salute e il diritto alla autodeterminazione maturata nella riflessione biogiuridica e bioetica. Il saggio enuclea il contenuto di questi principi attraverso una disamina del "tempo della relazione"
Prefazione dei curatori
No full textIl volume raccoglie alcuni dei contributi presentati nelle giornate di studio a cura dal Comitato Etico nell’aprile del 2018 presso l’Ospedale Cardarelli intorno al tema “Il comitato etico tra istituzioni e dilemmi” e nel novembre dello stesso anno presso l’Ospedale Santobono Pausilipon intorno al tema “Il comitato etico tra ricerca e pratica clinica”
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Group II metabotropic glutamate receptor ligands-induce neurogenesis in cerebellar granular cell cultures.
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