358 research outputs found
Develop and optimize quick crop protocols for sorghum and pearl millet & Rancidity in pearl millet
No full textTrip report of Dr Pooja Bhatnagar to Corteva HQ (agricultural division of DowDuPont) in Johnston in the United states
Multicomponent targeted proapoptotic anticancer drug delivery system
No full textCancer is one of the leading causes of death in United States. The current approaches for the treatment of solid tumor available are the surgery for the removal of primary tumor followed by chemotherapy and /or radiation. The efficacy of chemotherapy is limited by the following factors; (1) adverse side-effects on healthy organs, (2) development of cellular resistance and (3) low solubility of many anticancer drugs. The primary objective of this dissertation is to overcome all the above stated limitations. The methods employed in this dissertation includes designing, synthesizing and evaluating a novel drug delivery system comprising of 1) multiple copies of an anticancer drug, Camptothecin (CPT) ; 2) a polymeric carrier, Polyethylene glycol (PEG); 3) multiple copies of a targeting moiety to cancer cells, Luteinizing hormone releasing hormone (LHRH) peptide; 4) multiple copies of a suppressor of antiapoptotic cellular defense, BH3 peptide both in vitro and in vivo on A2780 human ovarian carcinoma cells and malignant ascites and animal models respectively. Conjugates of CPT, LHRH and CPT, LHRH, BH3 were evaluated for cytotoxicity, cancer specificity and antitumor activity. The multicomponent anticancer delivery system will significantly enhance the efficacy of an anticancer drug in the treatment of all the stages of cancer when compared with free drug, non-targeted delivery systems or the system consisting of one copy of each active component.Ph.D.Includes bibliographical referencesIncludes vitaby Pooja Chandn
sj-docx-1-cpc-10.1177_10556656211052781 - Supplemental material for Next Generation Sequencing and Cytogenetic Based Evaluation of Indian Pierre Robin Sequence Families Reveals CNV Regions of Modest Effect and a Novel <i>LOXL3</i> Mutation
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656211052781 for Next Generation Sequencing and Cytogenetic Based Evaluation of Indian Pierre Robin Sequence Families Reveals CNV Regions of Modest Effect and a Novel LOXL3 Mutation by Anubhuti Sood, Uzma Shamim, Om P. Kharbanda, Madhulika Kabra, Neerja Gupta, Aradhana Mathur, Aditi Joshi, Shaista Parveen, Sana Zahra, Pooja Sharma, Malika Seth, Afreen Khan, Mohammed Faruq and Deepika Mishra in The Cleft Palate-Craniofacial Journal</p
sj-docx-2-cpc-10.1177_10556656211052781 - Supplemental material for Next Generation Sequencing and Cytogenetic Based Evaluation of Indian Pierre Robin Sequence Families Reveals CNV Regions of Modest Effect and a Novel <i>LOXL3</i> Mutation
No full textSupplemental material, sj-docx-2-cpc-10.1177_10556656211052781 for Next Generation Sequencing and Cytogenetic Based Evaluation of Indian Pierre Robin Sequence Families Reveals CNV Regions of Modest Effect and a Novel LOXL3 Mutation by Anubhuti Sood, Uzma Shamim, Om P. Kharbanda, Madhulika Kabra, Neerja Gupta, Aradhana Mathur, Aditi Joshi, Shaista Parveen, Sana Zahra, Pooja Sharma, Malika Seth, Afreen Khan, Mohammed Faruq and Deepika Mishra in The Cleft Palate-Craniofacial Journal</p
Offshoring and outsourcing of core corporate activities: the global relocation of pharmaceutical industry clinical trials
No full textThis dissertation examines the offshoring and outsourcing of core activities in the pharmaceutical industry. Using primary and secondary data sources, the dissertation adopts a multi-level approach to examine four research questions related to the sourcing strategies of core activities such as clinical trials. Specifically, I look at operational and strategic factors that influence the decision to relocate core activities both organizationally (in-house versus external vendors) and geographically (activities conducted in home nation versus trials in foreign countries). Drawing on Dunning's framework, the dissertation next examines the role of four motives (resource, market, efficiency and strategic asset seeking) in the offshoring decisions while distinguishing between offshore outsourcing and offshoring to foreign affiliates. Using multiple case studies, the third study further investigates the evolution of firms sourcing strategies from conducting core activities in-house to increasingly outsourcing and offshoring them. The final study in the dissertation examines the impact of offshoring and outsourcing on the performance of core activities. Data for this dissertation comes from multiple sources: Primary data from in-depth structured interviews and online survey of vice presidents of clinical affairs of pharmaceutical and biotechnology firms, as well as secondary data from Medidata, Orbis, and World Development Indicators. The dissertation offers evidence that firms tend to use different sourcing strategies for different motives. Specifically, offshoring to foreign affiliates is primarily driven by strategic factors and firms tend to prefer this strategy for strategic asset seeking purposes. Offshore outsourcing on the other hand is motivated by resource and efficiency seeking behavior and the important determinants for this strategy are mainly operational. The third type of sourcing strategy is domestic outsourcing and firms are driven by both strategic as well as operational determinants for this strategy. The qualitative study on strategy evolution points towards a five stage process which begins with in-house sourcing followed by domestic outsourcing, foreign affiliates, offshore outsourcing and finally backsourcing of core activities. Evidence from the dissertation suggests that outsourcing has a positive impact on performance when compared to in-house while offshoring has a negative impact compared to domestic sourcing.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Pooja Thaku
NO to drought-multifunctional role of nitric oxide in plant drought: Do we have all the answers?
No full textNitric oxide (NO) is a versatile gaseous signaling molecule with increasing significance in plant research due to its association with various stress responses. Although, improved drought tolerance by NO is associated greatly with its ability to reduce stomatal opening and oxidative stress, it can immensely influence other physiological processes such as photosynthesis, proline accumulation and seed germination under water deficit. NO as a free radical can directly alter proteins, enzyme activities, gene transcription, and post-translational modifications that benefit functional recovery from drought. The present drought-mitigating strategies have focused on exogenous application of NO donors for exploring the associated physiological and molecular events, transgenic and mutant studies, but are inadequate. Considering the biphasic effects of NO, a cautious deployment is necessary along with a systematic approach for deciphering positively regulated responses to avoid any cytotoxic effects. Identification of NO target molecules and in-depth analysis of its effects under realistic field drought conditions should be an upmost priority. This detailed synthesis on the role of NO offers new insights on its functions, signaling, regulation, interactions and co-existence with different drought-related events providing future directions for exploiting this molecule towards improving drought tolerance in crop plants
Target reliability indices for quay walls, jetties, and flexible dolphins
No full textStructural codes rely on generalised target reliability indices, which are mainly derived for buildings. It is unclear, however, whether these indices are applicable to the specific risk-profile of quay walls, jetties, and flexible dolphins. In this study, target reliability indices for marine structures were derived from various risk acceptance criteria, such as economic optimisation, individual risk, societal risk, the life quality index, and the social and environmental repercussion index. This article uses a method to determine reliability targets distinguishing time-dependent and time-independent variables, because some important stochastic design variables in the design of marine structures, such as soil and material properties, are largely time-independent. The assessment framework of ISO 2394, taking into account social, economic, and environmental impact, has proven to be a solid basis for reliability differentiation. The method of approach considered in this paper can also be used for evaluating target reliability indices of other geotechnical structures.Accepted Author ManuscriptHydraulic Structures and Flood Ris
Transoesophageal Echocardiography Related Complications
No full textThe application of transesophageal echocardiography (TEE ) has been continuously increasing over past several decades. It is usually considered a very safe diagnostic and monitoring device. Though the complications are rare, but these complications must be known to the operators performing TEE. The goal of this article is to encapsulate the potential complications associated with TEE. The complications are primarily related to gastro intestinal, cardiovascular and respiratory systems along with some miscellaneous problems related to probe insertion, drugs and inexperience of the operator. Strategies for the prevention of these complications are also analyzed in order to avoid the risk
Dynamic Planning for Flexible Port Infrastructure after Panama Canal Expansion: A Real Case Study
No full textThis paper presents a study carried out to first assess the impact of the Panama Canal expansion (PCE) on selected Caribbean ports, and thereafter, to examine how the ports can adapt in order to seize new opportunities created by the expansion. An applied case of long-term dynamic planning and flexibility in engineering design is presented for a new port terminal in Barranquilla, Colombia. Furthermore, this paper presents the results of a stochastic method for quantifying opportunities from containerized traffic using dynamic forecasting, real options analysis, and Monte Carlo simulation, within the framework and spirit of adaptive port planning under uncertainty.Accepted Author ManuscriptRivers, Ports, Waterways and Dredging Engineerin
Expression of Keratin 19 in Relation to CDK Inhibiting Treatment of Breast Cancer
No full textA presentation that was delivered in the Fifth University Research Day at the Catholic University of America in 2020.This research was collaborated with Pooja Sharm
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