2,731 research outputs found
L-R: Katie Lee; Leo Walters; Bruce Berger sitting on a boat on the Colorado River.
No full textPhoto of Photo of Arizona folk singer and author Katie Lee (far left), Leo Walters (center), and writer Bruce Berger (far right), sitting on a raft on the Colorado River, Glen Canyon, Uta
Correction to: Idelalisib treatment prior to allogeneic stem cell transplantation for patients with chronic lymphocytic leukemia: a report from the EBMT chronic malignancies working party (Bone Marrow Transplantation, (2021), 56, 3, (605-613), 10.1038/s41409-020-01069-w)
No full textThe Idelalisib treatment prior to allogeneic stem cell transplantation for patients with chronic lymphocytic leukemia: a report from the EBMT chronic malignancies working party, written by Johannes Schetelig, Patrice Chevallier, Michel van Gelder, Jennifer Hoek, Olivier Hermine, Ronjon Chakraverty, Paul Browne, Noel Milpied, Michele Malagola, Gerard Socié, Julio Delgado, Eric Deconinck, Ghandi Damaj, Sebastian Maury, Dietrich Beelen, Stéphanie Nguyen Quoc, Paneesha Shankara, Arne Brecht, Jiri Mayer, Mathilde Hunault-Berger, Jörg Bittenbring, Catherine Thieblemont, Stéphane Lepretre, Henning Baldauf, Liesbeth C. de Wreede, Olivier Tournilhac, Ibrahim Yakoub-Agha, Nicolaus Kröger, Peter Dreger was originally published Online First without Open Access. After publication in volume 56, issue 3, page 605–613 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0. Open access funding enabled and organized by Projekt DEAL
Development of new tools to determine diagnosis and prognosis of patients with myeloproliferative neoplasms.
No full textPlusieurs scores pronostiques ont été élaboré chez les patients atteints de leucémie myéloïde chronique (LMC) sans qu’un lien n’ait été établi entre ces scores et la biologie de la LMC. Nous montrons que les patients de mauvais pronostic ont une expression accrue de GATA2, en corrélation avec les taux de basophiles et de plaquettes au diagnostic, paramètres utilisés dans le calcul des scores pronostiques, et à l’expression de gènes impliqués dans le fonctionnement des basophiles. Cette expression augmente lors de la transformation sur un versant myéloïde. Alors qu’un certain nombre de patients peuvent désormais tenter un arrêt de traitement avec un succès dans 50% des cas, il apparaît essentiel de revoir notre manière d’évaluer le pronostic. Ainsi, l’obtention d’une réponse moléculaire optimale dès 6 mois est associée avec une tentative ultérieure d’arrêt de traitement dans notre cohorte. Alors que le diagnostic de la LMC est relativement aisé, il est parfois difficile de différencier thrombocytémie essentielle (TE), pré-myélofibrose et myélofibrose. Nous réévaluons l’intérêt de la numération des cellules CD34+ circulantes: un nombre de cellules CD34+ circulantes < 10/μl permet d’exclure le diagnostic de myélofibrose avec une très bonne sensibilité (97%) et spécificité (90%). Dans une cohorte de patients atteints de TE avec mutation CALR, nous montrons que l’augmentation de sa charge allélique, et non la présence de mutations additionnelles, est associée à un risque accru de progression. L’ensemble de ces paramètres sera étudié dans une étude prospective multicentrique visant à établir un score diagnostique non invasif permettant de différencier TE, pré-myélofibrose et myélofibrose.Various scoring systems have been successively elaborated to predict outcome of patients with chronic myeloid leukemia (CML). However, no link has been identified between those scores and CML biology. We show that high-risk patients have high GATA2 levels, in correlation with higher baseline basophil and platelet counts, two parameters used to calculate prognostic scores, and expression of genes involved in basophils. GATA2 expression increases in accelerated and myeloidblast-phase. Since some patients can now stop treatment, with a near 50% success rate, it is necessary to reevaluate the way we assess prognosis. A 6-month optimal molecular response was associated with an increased discontinuation attempt rate in our cohort. While the diagnosis of CML is fairly easy, it is often difficult to distinguish essential thrombocythemia (ET), pre-myelofibrosis and myelofibrosis. The numeration of CD34+ circulating cells is of interest in this setting : we show that a number < 10/μ excludes the diagnosis of myelofibrosis with a very good sensitivity (97%) and good specificity (90%). In a cohort of patients with ET and CALR mutation, We show that an increase in allele burden, and not additional mutations at diagnosis or during follow-up,is associated with an increased risk of progression. All of these parameters will be evaluated in a prospective multicentric study in order to elaborate a non-invasive diagnostic score to distinguish TE, pre-myélofibrosis, and myelofibrosis
Deutsche Kriegslieder / hrsg. von Anna de Lagarde geb. Berger und Mathilde Berger
No full textAppartient à l’ensemble documentaire : BNUStras1Appartient à l’ensemble documentaire : BNUStr017Appartient à l’ensemble documentaire : BNUStr000Chanson
René Berger, L’Art vidéo
No full textL’Ecole cantonale d’art de Lausanne mène un projet de recherche visant à retracer les phénomènes d’exposition de l’image en mouvement, et publie dans ce cadre une sélection de textes historiques de René Berger. Figure importante en Suisse, conservateur, critique, enseignant, René Berger a eu une influence majeure dans l’émergence des pratiques artistiques avec les nouveaux media : vidéo d’abord, et art numérique ensuite. Intitulé L’art vidéo, ce livre reprend une terminologie usuelle des anné..
René Berger, L’Art vidéo
No full textL’Ecole cantonale d’art de Lausanne mène un projet de recherche visant à retracer les phénomènes d’exposition de l’image en mouvement, et publie dans ce cadre une sélection de textes historiques de René Berger. Figure importante en Suisse, conservateur, critique, enseignant, René Berger a eu une influence majeure dans l’émergence des pratiques artistiques avec les nouveaux media : vidéo d’abord, et art numérique ensuite. Intitulé L’art vidéo, ce livre reprend une terminologie usuelle des anné..
Portrait de chercheure ::Isabel Margot-Cattin : propos recueillis par Line Vionnet et Mathilde Berger
No full textA phase 3 randomized, placebo-controlled study assessing the efficacy and safety of epoetin-α in anemic patients with low-risk MDS
No full textErythropoiesis-stimulating agents are first choice for treating anemia in low-risk MDS. This double-blind, placebo-controlled study assessed the efficacy and safety of epoetin-α in IPSS low- or intermediate-1 risk (i.e., low-risk) MDS patients with Hb ≤ 10.0 g/dL, with no or moderate RBC transfusion dependence (≤4 RBC units/8 weeks). Patients were randomized, 2:1, to receive epoetin-α 450 IU/kg/week or placebo for 24 weeks, followed by treatment extension in responders. The primary endpoint was erythroid response (ER) through Week 24. Dose adjustments were driven by weekly Hb-levels and included increases, and dose reductions/discontinuation if Hb > 12 g/dL. An independent Response Review Committee (RRC) blindly reviewed all responses, applying IWG-2006 criteria but also considering dose adjustments, drug interruptions and longer periods of observation. A total of 130 patients were randomized (85 to epoetin-α and 45 to placebo). The ER by IWG-2006 criteria was 31.8% for epoetin-α vs 4.4% for placebo (p < 0.001); after RRC review, the ER was 45.9 vs 4.4% (p < 0.001), respectively. Epoetin-α reduced RBC transfusions and increased the time-to-first-transfusion compared with placebo. Thus, epoetin-α significantly improved anemia outcomes in low-risk MDS. IWG-2006 criteria for ER may require amendments to better apply to clinical studies
Configurations of Values
No full textCentral to public debates about commonalities and differences between citizens of different religious and cultural backgrounds is the compatibility of cultural values and the norms through which these values are actualized. Values, and changes in value systems, are the central theme in Chapter 14 of this volume, in which Peter Berger discusses a specific strand of structural anthropology that he emphasizes can be useful in the analysis of both empirical and historical data: the theory of value as developed by Louis Dumont, which has its roots in Durkheim’s sociology of religion. Berger begins by contextualizing Dumont’s theory in the history of the discipline of anthropology by outlining the main features of Dumont’s analytical framework and how it has been developed by Joel Robbins. He sketches how Dumont, informed by his Indological and anthropological research on the Hindu caste system, developed a general theory of hierarchy, the latter being just the other side of the coin of value (as posing a value introduces hierarchy). While Lévi-Strauss was mainly concerned with binary oppositions in cultural structures, Dumont argued that relationships between ideas are hierarchical. Left and right, for instance, are not simply opposites but stand in a hierarchical relation. When taking an oath or shaking hands after making an agreement, only the right hand is appropriate because it stands for the whole person. Dumont discussed the various properties of value and added the concepts of “context” and “level” in order to account for a dynamic relationship between ideas and values within a certain framework he called ideology. Joel Robbins further developed the dynamic potential in Dumont’s theory in explaining processes of change and globalization. In line with Mason’s argument that the label of “religion” as a universal cultural category often obfuscates more than it illuminates outside the Western world, the author demonstrates that the theory of value as developed by Dumont and Robbins provides an important perspective from which to study religion, precisely because it does not depend on “religion” as a privileged analytical concept or domain
mSphere of Influence: Resolution of the structure of an influenza virus polymerase is a game changer
No full textMathilde Richard works in the field of virology, more specifically on the evolution and pathogenesis of influenza viruses. In this mSphere of Influence article, she reflects on how the two articles "Structure of Influenza A Polymerase Bound to the Viral RNA Promoter" by A. Pflug, D. Guilligay, S. Reich, and S. Cusack (Nature 516:355-360, 2014, https://doi.org/10.1038/nature14008) and "Structural Insight into Cap-Snatching and RNA Synthesis by Influenza Polymerase" by S. Reich, D. Guilligay, A. Pflug, H. Malet, I. Berger, et al. (Nature 516:361-366, 2014, https://doi.org/10.1038/ nature14009) made an impact on her by providing new grounds to study the influenza virus polymerase and its role in virus biology and evolution
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