41 research outputs found
The development of metal complexes for potential anticancer drugs, 2015
No full textThis study examines the synthesis and biological importance of two transition metal complexes with ligands that show high antiproliferative potency to prostate cancer.Transitional metals have shown an important role in cancer therapy and research, where the use of transition metal complexes can treat several human diseases like carcinoma, and lymphomas, etc. By design, Dr. Bu's lab has created potent ligands (Imidazopyridine, IMP) that can effectively kill metastatic prostate cancer cell lines, which will serve as organic carrier or chelator of the transition metals. A vanadium complex with a tridentate imidazopyridine and an iron complex with bidentate imidazopyridine have been developed. Their biological activities against prostate cancer cell line (PC3) have been evaluated. Results have shown that ligand 2, [(5Br-2MeO)IMP, L2], a bidentate imidazopyridine, is more potent in biological activity than ligand 1, [(5-Cl-2HO)IMP, (HL1)], a tridentate imidazopyridine. The metal complexes are found to greatly enhance the antiproliferative activity on PC3 prostate cancer cells compared to their corresponding ligand
The promotion of the right of self-determination in international law and the impact of the principle of non-interference
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityThis dissertation presents an analytical study of the evolution of the right of political selfdetermination
and the influence of the principle of non-interference on promotion of this right. The intellectual and legal interests in democracy, good governance and social justice have contributed to the development of this right and its realisation for peoples lacking the least degree of good governance. The right of political self-determination is strongly associated with international intervention because governments facing popular demands for this right often resort to repression and military means to suppress such claims. Such interventions have also been driven by contemporary interest in supporting collective rights through international organisations that monitor and identify violations of various political rights. Thus, this dissertation focuses on the tension between the principle of non-interference and the modern legal trend to promote the political rights of all peoples. This research contributes considerable insights into the transformation of the principle of non-interference from an absolute obligation into a flexible concept by tracing the contributing legal changes both in international practices and in emerging rules and principles in international law. It is
concluded that the promotion of the right of self-determination has resulted in international practices that have dramatically influenced and caused tension with the principle of noninterference. Keywords: right of political self-determination, democracy, statehood, the principle of noninterference, international intervention, sovereignty
Improving Blockchain Resilience to Network Partitioning by Sharding (Poster)
No full textBlockchain plays a significant role in cryptocurrencies and growing applications like smart contracts. However, prior blockchain algorithms did not consider large-scale network partitioning a considerable concern while relying heavily on a reliable global network. Previous works have shown a possibility of a massive disruption on the Internet. The author in [Jyothi, 2021] discusses the case of Internet disorder due to solar superstorms, which can disconnect different geographical regions from each other for months. Partitioning attacks are also notable concerns that should be considered, in which their goal is to cut connections between a set of nodes and the rest of the network.
In the case of network partitioning, the main chain will fork into branches, and miners in different disconnected regions will create multiple blocks in parallel. The longest chain rule in current blockchain systems accepts only one of the branches after the network is recovered, and because of that, all blocks in other branches will be pruned. Losing a considerable number of mined blocks is not tolerable and significantly impacts the reliability of the ledger and miners' benefit.
In this work, we aim to improve blockchain resilience by designing a partition-tolerance blockchain system that: (1) split into branches when network partition happens. (2) merge existing branches into one when the network goes back to normal. (3) ensure the safety and integrity of the blockchain.
Newly mined blocks will be collectively signed by a group of miners with a BFT protocol similar to ByzCoin[Kogias et al., 2016], where the consensus group is formed by the miners of the previous w blocks. When a network partition happens, only part of the consensus group can be reached; thus the number of signers w_b of the new block will be less than w. If a block with w_b signers is published, every node in the partition learns that they are now in a branch with around w_b/w of the total hashing power, and it can be identified by the signature of the block. After the network recovers, miners will receive multiple branches, and they mine on a merging block which points to the last block of each branch as the parent blocks. The consensus group will be selected from each branch according to the branch size. Transactions in each partition are preserved after merging
Investigations in Patient Education Resources & the Generation of Generic Templates for Computerized Patient Education for Cancer Patients
No full textInternship Report - Summer 2012The aim of the report was to complete the MHI- internship requirement. This internship was accomplished in NICHE research group under supervision of Dr Raza Abidi. The major purpose of the internship was to apply health informatics concepts and theories. This was during the evaluation of two different patient educational materials and generation of templates, thus providing general guidance for health professionals in producing patient educational materials. Several phases were accomplished during the project. The first study aimed to evaluate online websites against certain criteria. These criteria were website reliability and website content readability. The author used different measures to assess readability such as SMOG F-K Grade and FRE. Other criteria such as sponsorship, audiences, currency and factual information were used to assess website reliability. In addition, the author used DISCREN tool for reliability and treatment choice appropriateness. This study concluded that reliability of these websites was not an issue within the study sample; rather readability was the main issue. Therefore, the author suggests some recommendations that could help to improve patient interaction with these websites during the research study. These recommendations were;
? Readability of patient educational materials should be below the sixth grade, matched with population literacy and easily understood.
? Recommendation of Patient tailored education materials.
? Physician or patient-educator should have a role in directing patient to reliable- evidence based resources to aid patient in taking informed decisions related to their health.
? Websites should use interactive tool or illustrations to increase patient understanding of the provided material.
The second study was similar to Study I; however, it differed in resource format. This is because, in Study II, the format was patient information leaflets (PILs), which are widely used in hospitals and clinics. In Study II, the author used similar criteria to Study I to evaluate PILs. Study II reached the same finding as those of Study I. Thus, readability was the barrier towards production of valuable materials that would enable patients to make an informed decision. Thereafter, the author made comparisons between the two studies. This comparison was followed by generation of five templates whose contents were abstracted from the educational materials from Study I and II. The main objective of generating these templates is to aid health professionals in producing valuable health education materials. However, these templates were retested with another set of materials to ensure that they produce complete coverage of educational concepts. The last phase in the project was the generation of Cancer Patient Educational Materials that acted as artifacts for the previous templates produced in the second phase of the project.NICHE Research Group, Dalhousie Universit
The impact of COVID-19 on pharmacy education in Saudi Arabia
No full textAbstract: In late 2019, the first COVID-19 case was announced. Subsequently, numerous other instances were found all around the world. On March 2, 2020, the first case was reported in Saudi Arabia. The Saudi government has taken several precautions to stop the spread of this pandemic sickness. Closing public and private schools and universities and moving educational activity to online platforms were two of these approaches. whether they are the 21 public pharmacy schools in Saudi Arabia or the. These abrupt transitions had an impact on 8 people, and depending on their level of preparedness, they responded differently. Here, we discuss the elements of the pharmacy school curriculum, including classroom instruction, laboratory work, and experiential learning, based on our experience at King Saud University.
Keywords: Pharmacy education COVID-19 Assessment Lesson learned.
Title: The impact of COVID-19 on pharmacy education in Saudi Arabia
Author: Yasir Awad Ahmed, Bander kammash alshammari, Faisal Abdulrahman Al Amri, Turki Shafaq Alotaibi, Mazen Alawi Nubayri, Jamelah Ali Alshehri, Noha Ali M Alshehri
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 10, Issue 3, July 2022 - September 2022
Page No: 89-93
Research Publish Journals
Website: www.researchpublish.com
Published Date: 26-September-2022
DOI: https://doi.org/10.5281/zenodo.7113029
Paper Download Link (Source)
https://www.researchpublish.com/papers/the-impact-of-covid-19-on-pharmacy-education-in-saudi-arabiaInternational Journal of Life Sciences Research, ISSN 2348-313X (Print), ISSN 2348-3148 (online), Research Publish Journals, Website: www.researchpublish.co
Preliminary Computer-based Healthcare System for Ministry of Health of Syria
No full textInternship Report - Summer 2009This internship work is an initial step in designing a Healthcare System for the Arabian Republic of Syria. Syria itself is located at the eastern edges of the Mediterranean Sea, at the Middle East area in Asia. It has a population of almost 20 million people. Syria is divided into 14 governorates. Each governorate has a number of regions. Each region has many districts and each district includes many villages. The Ministry of Health in Syria runs the Healthcare System in paper-based format. Information is often duplicated in the various forms used in the Syrian healthcare system. Ministry of Health in Syria is currently using more than 120 forms and reports in their healthcare system. Developing a computer-based system would increase the productivity, efficiency and accuracy for healthcare outcomes The Arabic language is the only official language in the forms of the Syrian Healthcare Paper System. Important to the success of transferring the Syrian Healthcare system from a paper based system to an electronic system is a solid knowledge of both English and Arabic languages. The Author obtained 128 forms from Dr. Graven to organize in such a way that would make them uncomplicated and easily understood to anyone working in healthcare administration. Identifying the repeated main forms and the repeated information in the forms of the different departments was a main focus. Extracting all the fields from all the main forms, translating all the fields including the Arabic Medical Terms into English was the biggest task in this internship. Creating a Data Dictionary is an important step in the design of a database to provide a description of the forms’ content. The Author created a data dictionary that contains a unique ID number and name for every main form and its fields. Entering the required fields into an Excel sheet in both languages (Arabic and English) was the last task.Neonatology, IWK Hospita
Firewall virtualization prototype for grids
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
Researchers can access this thesis by asking their local university, institution or public library to
make a request on their behalf. Monash staff and postgraduate students can use the link in the References field
Irrational Prescribing Habit of Omeprazole
No full textThe primary aim of the study is to examine the frequency of omeprazole prescription from all the prescriptions received by a pharmacist in a single day. Besides, the author examines the cost of dispensed omeprazole. This research is inspired by the fact that medication errors were the leading cause of severe physical injury and death to patients. Additionally, such preventable errors are also associated with intense financial, emotional as well as psychological stress to both healthcare providers and the healthcare organization in general. The study adopted a cross sectional study through collecting as well as screening of all the prescription orders undertaken in one day from 7:30 am to 1:45 pm. The research found that a prescription error leads to wastage of the resources with estimated annual cost of 336,415.56 for omeprazole as well as 431037.984 USD for ranitidine while at the same time necessitates the rational prescription habit to suppress the detrimental effects of omeprazole and ranitidine
Semi-mechanistic modelling of neutropenia
No full textPopulation pharmacokinetics and pharmacodynamics PKPD modelling of chemotherapy-induced neutropenia can help with efficacy optimization and toxicity prevention in cancer patients. These medications focus on the fast- growing cells within the body and destroy them. Most of the fast-growing cells in the body are usually cancer cells, but there is an increased chance that certain healthy cells, such as white blood cells could be killed during chemo- therapy. Several approaches have been identified for different drugs. Both empirical and mechanist approaches are discussed in this paper. Further, the author identified the pharmacokinetic-pharmacodynamic profile described by Friberg et al. (2003) as the most commonly used. This model consists of five sectors that represent proliferation, maturation, as well as elimination from the circulation of the neutrophils or leucocytes. This review covers these aspects and promotes a full understanding of dose prediction using semi-mechanistic modelling
Providing pharmacy services during the coronavirus pandemic in Saudi Arabia
No full textAbstract: On March 2, 2020, the Kingdom of Saudi Arabia confirmed its first case of the emerging coronavirus strain that causes coronavirus disease 2019 (COVID-19). Shortly thereafter, the number of confirmed cases nationwide began to rise. Since the looming outbreak, all healthcare professionals, including pharmacists, began to work at maximum capacity and effort. The Saudi Society of Clinical Pharmacy (SSCP) recognizes the significant impact pharmacists can have during outbreaks. Based on the scientific evidence available during this outbreak, the SSCP set up an expert working group to conceptualize and draft proposed recommendations that highlight the roles and responsibilities of pharmacists during epidemics and pandemics. The SSCP working group made 28 recommendations. In addition to national and institutional guidelines, these recommendations could serve as guidance for affected entities.
Keywords: Pandemic, COVID-19, Pharmacist, Saudi Arabia.
Title: Providing pharmacy services during the coronavirus pandemic in Saudi Arabia
Author: Saad khalaf alshammari, Ahmed Masoud AL-Qahtani, Ahmed Mazi Alotaibi, Naif Ahmad Alzahrani, Emad Ahmed Alzahrani, Susan Abdulqader Alkhulaif, Waleed farah alharbi, Salem ahmad albraiki, Awad ghalab almuteiri, Nawaf Ateya Alzahrani
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Vol. 10, Issue 2, October 2022 - March 2023
Page No: 147-153
Research Publish Journals
Website: www.researchpublish.com
Published Date: 28-November-2022
DOI: https://doi.org/10.5281/zenodo.7371179
Paper Download Link (Source)
https://www.researchpublish.com/papers/providing-pharmacy-services-during-the-coronavirus-pandemic-in-saudi-arabiaInternational Journal of Healthcare Sciences, ISSN 2348-5728 (Online), Research Publish Journals, Website: www.researchpublish.co
