3 research outputs found
DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer
No full textWe are evaluating the use of electroporation (EP) to deliver a novel DNA vaccine, p.DOM-PSMA(27). This vaccine encodes a domain (DOM) of fragment C of tetanus toxin to induce CD4(+) T cell help, fused to a tumor-derived epitope from prostate-specific membrane antigen (PSMA) for use in HLA-A2(+) patients with recurrent prostate cancer. We report on safety and tolerability and on antibody response to DOM as a first indication of the effect of EP in patients. In this open label phase I/II, two-arm, dose escalation trial DNA was delivered either by intramuscular injection or by intramuscular injection followed by EP (DNA+EP), with five patients per dose level. Three vaccinations were given at 0, 4, and 8 weeks,with booster doses at 24 and 48 weeks; here we allowed crossover between study arms if supported by the safety and immunological data. In the 20 patients in the first two dose cohorts we observed that beyond brief and acceptable pain at the injection site, EP did not appear to add toxicity to the vaccination. We evaluated humoral responses to DOM. Low anti-DOM IgG antibody responses were observed after intramuscular injection of DNA without EP (at week 12: mean 1.7- vs. 24.5-fold increase over baseline with DNA+EP). These could be boosted by delivery of DNA+EP at later time points. Delivery of DNA+EP at all five vaccinations yielded the highest levels of anti-DOM antibody. Responses persisted to 18 months of follow-up. These data establish EP as a potent method for stimulating humoral responses induced by DNA vaccination in humans
The role of Umkhonto we Sizwe (MK) in the national liberation struggle in South Africa with reference to the rural far northern Transvaal, 1976-1990
No full textIncludes bibliographical references (leaves 250-275)
0000
No full text. THB WKATHKR.
Kan Francisco, Marrh I'I.—
Fair, warmer Itmight: rlomlj
Kstarday.
M'ADIK. Foi*ec**ter.
Hatty PaUi Alto Straws
NOW ROR
GREATER
PALO ALTO
FAl.O
i \i.IFOKNIA, FKIDAY. MARCH ii, 1909.
NO. 58
-st*>*i4is4*.w*wa**aaisi4iisis**44M
FAMILY SCALES
WITH 1 MI..I 01A1H CAN UK IXSTAXTLV AIUV8TKI. POR
PLATK, lll-kl.l OB -• ,»„■ CAP UTTV S. I-OfXlsS. BV
OUNCES. INVALUABLE Tt. I-KOI'KH tXKlKINO
Keep Check on Your Purchases
WILL SOON I'AY VOK THEMSKLVK8. VtH, Wl 1.1. FINK
■
1 HIM AT THB ,
Palo Alto Hardware Company
Itlirrl la the Orate. 04* IB. Cat,
maa^isi ■ 'tummm*. issi*
xaju. raora
ralo auto 11
DUDFIELD
Lumber Co.
Palo AJto
Imported
Smyrna
Figs
at
COMPTON'S
only
321 University Ave.
CHINESE GIRLS FAMILY FERTILE MAY HEARING
SWEET^SINGERS IN EXPEDIENTS POSTPONED WEEK
MISS l.ll-iAl.lllNA OAMKBONJVHTIMS OF POVERTY. BUT ATTOHNKV UII.I.IAM lU.WI.KK
TRLL8 OP HKR Ill's, I I. WORK < KIIRKWII KNOt'till TO KREP 1'I.KAI*. ILLNESS AND (WIS
IX SAX I'll \\> is, ., THK WOLF AWAT. DSLAT.
SPRING FOOTWEAR
Our New Styles are
here. The newest creations in patterns and
lasts.
See the new tans.
NOTED SUFFRAGIST
GIVES INTERVIEW
MIL** « I \l"\ li OOUn KMFHA-
-l/ls MID or POLITICAL
WtlRX BV HOMKV
j Hope* ta Help Defeat All
t-pra Wbo Voted A-ralast GO*.
Mltatioaal Amcadmrai.
"1 bop* to com* back to California during tbe next canijis.gn and
help the women of thl* stste tn their
effort to defeat every legislator who
voted against submitting tk* woman's suffrsae constitutions' ***** Ad
m*nt to th* voters at th* next •(action. *'
Such was ths statatnent mad* by
Mr*. Clara Bewick Colby In an In-
terrlew laat Bight Mrs. Colby I*
oa* of Us* beat-keowB suffrage ad-
vooaiaa IB America snd is a most
interesting talker
In speaking nf her attandanc*
test year at the laternattooal Wo*
msB's Alliance In Holland, sh* aald
that nearly a score of nations were
repreeeaud and tbat dvrtag that
rear •***» countries bad granted
increased suffrage to woman, while
since thea Sweden and New Sooth
Wales have been added to Ihe Hat.
"Tb. -BOv*tn*nt in tbls country."
sb* aald. "baa not tha force that It
bas galBsd tn other countries I believe tbe time has corns for sctlon.
ths time for argument la past The
women most get In and work for
their friends The politician* are
slready afraid of ns, aad we muat
give our bast efforts to elect those
wbo ar. to eympathy we mest do
politic*! work.
"The women are a ressrve fore*
In the political life of the country.
The men have done ther work
grandly, aad tb* women hav* done
their work fairly w*ll But new
roodlttoaa esist snd the united vote
of tbe men aad woman Is needed to
help forward tbe great economic
and philanthropic movements of the
present There would thus b*
greater combined rote for good
government, aad th* power of the
bosses woald be minimised."
Mrs. Colby Is an aunt or Mrs II
W. Da*,, and will make her bead
quarters h*r* during March, while
: she delivers addresses at San Jo**,
j Berkeley, Oakland and other points
around the bay.
\ family named Hoistein that haa
been living In Palo Alto for some
time In apparent destitution bas
proved tbat Ita members are fertile
In resource* and has skillfully
abused the generosity nf a number
of dtlsans
Tbere are a husband aad wife and
several small children In th* family.
The husbsnd is a bakor and mlll-
man and handy man generally H*
gave up a good situation, saying
that he did not care to work, as be
could get along without It. Thea
the wife went out as charwoman at
'■'■': cents an hour and had plenty ot
work. One of the methods was to
send the husband to collect her
wages, lhe Ml) generally being
made out for more time tbau she
had worked, and he made things bo
unpleasant tbat tha bill waa ususlly
paid to avoid troabl*.
Tbe woman went aronpd fo business place* and Individuate pleading
destitution and asking aid. Sbe
secured mucb help In this way and
a number of persons have given
hsr five dollars each In the past two
weeks. But her best hit was oo
Tuesday night when sbe appeared
before the carpenters! onion and
told a touching tale of poverty. She
said her husband had gone to Saa
Pranrlsco to eeck work and tbat
not only was there neither money
nor provisions In the home, but
tbat the city authorities had shut
off tbe water, because she bad no
money to pay the bill.
Tbe unton men never turn down
an appeal for help nor stop to investigate. "nOi* war'tlwlr-v-ttnii get*,.
eroelty lacking In tbls Instance.
Dollars dropped Into th* hat Ilka:
a shower of leaves to autumn and I
lhe woman went her way with a
1'tirsv well filled Indeed.
On Thursday morning an express:
wagon appeared In front of the Hoistein abode the household effects]
The hearing of Fred 11. May ow
a charge of criminal lib*! preferraat
by R P. Welashaar. which has bees-,
delayed sine last August and which*
was set for hearing today befors*
Jusllco Van Buren at Mayfleld. baa
again been postponed1.
Attorney William Bowden of Saw
Joee, who represent* Mr May, an-
nounced lhal he wa* loo 111 to ba
preeent and Dlatrict Attoraey Trom
consented to l*t tbe bearing go over
and ro*et the date for Friday of
next week.
Mr. Welsahaar will be r*p*****nt«sl*
by Attoraey Frank H. Gould of San
Franclaco, on* of tbe ablsat law-
yera In the stste. The bearing wlO
doubtleaa be somewhat protracted.
as a larg* number of w|tn*e**a hav.
been subpena*d for both tha prosecution, and the defense. The matter will be vlgoroualy preeested hr
both side*.
Begin Work ob Hoagatal.
The building commlttM of tha
Peninsula hospital authorised Architect Lanmelater today to, aet tb*
stakes for excavating tha liaaaniBisT
for the building at once. Tbe contract for tbe escavatloo haa baaar
awarded to Thomas Cardoso and hat
will begin work tomorrow. Therw
are several thousand yards ot dfrt
t* be removed, asd It will take somw-
tlme to oomnWa th* contract.
m*m^*m^nflmm^mmm*mmm*st****9
Did You Hear
Something Drop?.
IT WAA THK PRICK OF SSfU AT-OUB 4TOK*.
SALE NOW ON
Ho cheap that yon wtll we-wdrr bow we ca* get eeeta.
We t~swss] a asa. who bsd too many Tow-sis aad 1
tt**-, and aow we hare too maay, aad are wUl gin
kisnfit Tbey wiB go fast st owr very low price.
(V>MK QTICR IF M **VA**T TH.CM.
MeKiBBEN BE4LC0.
PHONE 12
| Mtss Blgler. who has beea ao a*ri-
; onsly 111 for several weeks st tb*
. II K. Cbttds home on Cowper street,
■ is now able to sit up each day. M.
j D Wellla la filling ber position Ib
I the First National Baak.
Hot-tor lk-siil.* Deliver* Addnas on! Pitiful Ilea* Imposed t'pon the Hearing Reef* tor Next Friday Be-
Hoasr Missions—Me* i Ing Ad- ' ' t;.-iirr>.*tty of lllista* Family tore Jasticc Van Bar** at
.uniaid Today. Seek* New Field. Mayfleld.
A large audience gathered at th*
Presbyterian Church laat evening
for the program which had been
prepared on missionary work, many
present being members of other'
churches In Palo Alto.
The first address of the evening
was given hy Rev. Andrew B**tlie.
hla subject being "Home Missions."
Doctor Begttl* showed very clearly
the great need of missionary work
In our own country among th* Chine**. Japanese, negroes and tbe
southern mountaineers. speaking[
alao or lhe work to be don* and!
that la being done ln Alaska and
the Philippine Islands, wblcb comes
under lhe direction of the home
board. A large number of the
churches In th* I'nlted States also
arc not self-supporting, and Doctor 1
&Battle made an especial plea fori
tale* for these congregation* He
aaid. eery significantly, that minis-
tars of th* gospel are ao poorly,
paid, many of tbem receiving barely!
$S0D a year, that unless the larger
churches open their hearts and
tbelr pur*** 10 the weaker congr*-;
gallons the paator* wlll he called
apon to leave tbe ministry for other
professions or remain single men.
The trio*, duets and solos by the I
little Chinese girl* from th* Saa!
Krant**sf*o mission home which la;
superintended by Mtae Donaldlna'
Cameron were very pleasing and j
th* quaint singer* were encored several times They poses** sweet
voices and show a sense ot harmony .
not generally attributed to the Chi-:
neae. Tn*y aro attractive little woman and shoy very plainly the value
of auch nilsslsn work on our
own. coast.
Mlaa Cameron's account of th*
rescue work among the slave glrla
In San Francisco's Chinese quarter
and from the ocean liners which
bring the girls to California to be
sold Into slavery, was intensely interesting Mlas Cameron Is not
only a woman of great faith and
sweetneea of character, but Is fearless In dealleg wltb Chleeae trickery and cunning She levee her
girls and one can readily aee the
great influence she hss exerted on
their lives. Sbe told a number or
Incidents connected wltb the rescue'
work. In which she, dsputy sheriffs
and Chinese sieve dealers figured,
which wer* very Interesting, and
ahe closed by extending a very cordial Invitation lo ber audience to
visit Presbyterian headquarters In
San Franclaco to learn or th* work
personally. ———
Miss Cameron baa attr*sct*d worldwide attention beeauae of her work
among Chinese girls In San Pranclsco. in sn article la Everybody's
Magaxlne several years ago Wallace
Irwin reviewed ber work aod psld
her the highest tribute, and Mabel
Claire Craft, formerly a well-known
writer, alao wrote of the mission
and the strong personality behind
It—-Mlaa Cameron—in an eastern
periodical.
The missionary meeting that bas
be«n in session -her* two days
closed Its work tbls sfternoon.
Rlls— Ths battle with lh* sluuv
■tese**** »s»»e»****s ***.*ee'se*
ARCHITECT.
n. Alexander Wr'ght (of Wright,
rtu*hforth A Cahlll, aaaoclsts archl-
te. is. Ban Franrteco). Resident**
Klngaley and Waverley, Palo Alto.
Pbone 1ML.
were packed snd taken to the railroad aad the family departed for*
San Francisco. It is and era to©*
that the fntnltuTe taken away www
bought from local dealer* asd that
psymsot for It bad not been and*.
lt Is alleged, though oot proven.
that th* maa was guilty of graver
offenses than aay stated hara. . la-
fact, he hi generally he|l*r*d ta
have bean th* sight prowler wh.
created ao much disturbance recently.
Indiscriminate charity may ba
often lll-advlaad. bnt It ahow* tha
kindness of maaklnd In th* aggrw-
gat*. and perhaps tho*. who** coa-
fldsnc* Is abaead are none tha l«e*
happy on that account.
;.
BENWELL'S
Novelty Theatre
Jim-> Kher-tdsn Rnsrle** It"-
VIRGINIA
I* a great play.
Don't ml** Mlas K*l!erm*o.
THK CHAMPION EsUlT
SWIM MK11
V' I* h- I'M ON KIRK
la a craekerjack comedy
Tin TKNNIH ri; .Zi:
lis a dandy comedy.
THK CBIPn.KsV RACK
brlnga down the honae.
THK WOMlEItf-T'L FLAMKH
Thla Is a great handcolored
"Magle."
-Hong—**! 1-4»*l My Heart When
I SAW VOIR BY
I Haw Your Rye*.'*
Opera House
Robert A. Hazel Mgr.
IrOMT « , ,1111V — WATCH
It I.UIIW
Entire Change
of Picture*
EVERY DAY
Admission 5c To All
.Extra Attraction
RALPH RUDOLF
Hawaiian Contra-
Tenor
, WIU Talh oa Steveasoo's Ufe.
I The English Club haa arranged
X an entertainment for Wednesday I
• evening at S o'clock In the chapel. I
• It will be public and no admission \'
X will ho charged. President Dsvldj'
X Starr Jordan haa cons4«nted to de- ; [
♦ liver s lecture on ■'Tnsllals In Sa- ■ j
S nos" Tb* talk promisee to be of'
X Interest, ss Doctor Jordan lived for'
* ' some time in the lalanda. where be.
♦ was In a pos'tlon to become well)
• acquainted with Tiialtala. as Robert i
X ■ Louis Stevenson, tbe famous author--
X adventurer, was known by the Sa-
* . nutans Doctor Jordan la probably
S better acquainted with Stevenson'ai
J ; life than any other. A number of;
* . lantern slide* will be need to lllaa- i
* trate the let-tare.
X Jared Bonbam 1* down from Ssn
e .' Frsncisco greeting oldtlme friends.
Admission 5c To All
Opera House
noninrtT a. iiazcl.
iiivt WOIIHVI WATCH I'd
tntow
Friday and Saturday
GOOD
VAUDEVILLE
Admission 15c.
Reserved seats 25c.
Urate e4 WHsBrar-s-er-a.
Msttw
9:15. Kveala, 7:11 *
.............>.....,...♦
Some Specials
I Ita. Peaches .''... Jaw Cera. Beet. dos. 41.11
4 Iba. Silver Preae. tRr Co™- W". 4ex Mr
4 Iba. I,..,. mm *"'* ""* T"°'to* "»-•"*
Olives. Ml Mr
All lOe flplce.. tor a lew r>an ^ ,„
4a»a 4. r.arj Orasxee or Appioo.
Our .'.-ll. rsa ol CoSae le Kresb roast Pesnuis. ol ..5c
«..|||b« Isst ror fI.M Walnats, 11 1.14*
Sallows b Rhodes
Phone 73
• lacob RIU. ASSOB. Hsll. Marel 14 }
