348 research outputs found
Supplemental material for Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multi-dose preclinical paediatric drug studies
No full textSupplemental Material for Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multi-dose preclinical paediatric drug studies by Joske Millecam, Thomas van Bergen, Mathias Devreese, Stijn Schauvliege, Ann Martens, Koen Chiers, Siska Croubels and Gunther Antonissen in Laboratory Animals</p
Modelling the risks and consequences of residues of antimicrobial drugs in the gut and manure of pigs
No full textCeftiofur and cefquinome : the emergence and selection of antimicrobial resistance in the porcine gut microbiome
No full textDit proefschrift gaat in op het historische verwaarlozing van de gastro-intestinale uitscheiding en neveneffecten van antimicrobiële middelen, en benadrukt hun rol in het versnellen van antimicrobiële resistentie. Recent onderzoek benadrukte namelijk de significante impact van de opkomst en verspreiding van resistentie op de effectiviteit van antibiotica en de implicaties voor de humane en veterinaire geneeskunde, wat uiteindelijk aanleiding gaf tot het 'One Health' concept. Het Europees Geneesmiddelenbureau pleit nu dan ook voor het beoordelen van de verspreiding van antimicrobiële resistentie tijdens onderzoek naar antimicrobiële middelen
A novel approach in paediatric drug research : the development of a juvenile conventional pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case
No full textInteractions between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes in a porcine animal model
No full textInfluence of administration route and dose on intestinal concentrations of selected antimicrobials in pigs
No full textThe conventional pig as juvenile animal model for preclinical paediatric pharmacokinetic studies : focus on hepatic metabolism using ibuprofen as model compound
No full textEndectocide treatment of cattle as complementary tool for malaria control in Sub-Saharan Africa
No full textThis PhD primarily focused on determining an optimized dose of ML endectocides (via PK/PD studies) for indigenous Ethiopian zebu cattle for its use as new complementary malaria vector control tool. In sub-Saharan Africa (SSA), malaria elimination with current vector-control strategies is hindered by residual transmission. The residual transmission is mainly linked with the vector’s behavioral adaptation (outdoor biting and/or resting behavior) and insecticide resistance along with the abundance of zoophagic and anthropophagic vectors. Outdoor biting Anopheles mosquitoes tend to seek blood meals more from livestock mainly cattle as alternative blood meals source when humans are not accessible. Consequently, livestock blood meals contribute largely to vectors abundance and increased densities, even though animals are not a parasite reservoir for malaria disease. Hence, a complementary tool targeted to livestock, mainly cattle, is essential for the control of outdoor feeding zoophagic vectors to divert their blood meal source from toxic blood from animals. With this regard, mass treatment of cattle with an endectocide is a new approach. Animal species and breed difference have an impact on the pharmacokinetics(PK) of endectocides, thereby affecting or altering their optimal effects. In indigenous zebu cattle, PK data is scarce for macrocyclic lactone endectocides (ivermectin, doramectin and moxidectin). Therefore, For malaria vector control, an optimized ML endectocide dose was determined after the bioanalysis, PK-PD assessment of the ML endectocides in indigenous Ethiopian zebu cattle as described in this thesis. The effects of the sub-lethal concentrations on P. vivax parasite were also assessed
Safety of mycotoxin binders regarding their use with veterinary medicinal products in poultry and pigs : an in vitro and pharmacokinetic approach
No full textTowards risk assessment of emerging Alternaria and Fusarium mycotoxins : comparative toxicity and toxicokinetics in broiler chickens and pigs
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