239 research outputs found
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No full text... a new project around criminal anthropology prepared in the archives ...by Gaëlle Dubois, Gauthier Godart, Veerle Massin & Amandine Thiry #laboratory Author of the note : Veerle Massi
little papers
No full textThe secrets of the Cour d'Assises. Old Papers. Crimes. Murders. Early 20th century. AGR2, Bruxelles, Cour d'Assises de Brabant. Case file. Les secrets de Cour d'Assises. Vieux papiers. Crimes. Meurtres. Début du 20e siècle. #deburchgraeve Author of the note : Veerle Massi
martyr or monster ?
No full textSometimes, the criminal asks himself the question, tries to explain the crime and calls the Cour de Cassation. Demez Case, 1902. AGR2, Bruxelles, Cour d'Assises de Brabant, 1290. Parfois, le criminel pose la question lui-même, cherche à faire comprendre le crime et interpelle la cour de cassation. Affaire Demez, 1902. #deburchgraeve Author of the note : Veerle Massi
martyr or monster ?
No full textSometimes, the criminal asks himself the question, tries to explain the crime and calls the Cour de Cassation. Demez Case, 1902. AGR2, Bruxelles, Cour d'Assises de Brabant, 1290. Parfois, le criminel pose la question lui-même, cherche à faire comprendre le crime et interpelle la cour de cassation. Affaire Demez, 1902. #deburchgraeve Author of the note : Veerle Massi
little papers
No full textThe secrets of the Cour d'Assises. Old Papers. Crimes. Murders. Early 20th century. AGR2, Bruxelles, Cour d'Assises de Brabant. Case file. Les secrets de Cour d'Assises. Vieux papiers. Crimes. Meurtres. Début du 20e siècle. #deburchgraeve Author of the note : Veerle Massi
On the Sustainability of the MiFID II and IDD Investor Protection Frameworks
No full textFollowing its Sustainable Finance Action Plan, the European Commission has integrated sustainable finance concepts and strategies into the MiFID II and IDD conduct of business regimes. This contribution first sketches the behavioural problems explaining why retail investors do not always act upon their sustainability preferences and the potential role of the investment product distributor in bridging the gap between investors' values and actual investment choices. Against this background, the author offers a critical overview of sustainable finance provisions in the MiFID II and IDD investor protection frameworks and their relationship with the Sustainable Finance Disclosure Regulation and the Taxonomy Regulation
On the Sustainability of the MiFID II and IDD Investor Protection Frameworks
No full textFollowing its Sustainable Finance Action Plan, the European Commission has integrated sustainable finance concepts and strategies into the MiFID II and IDD conduct of business regimes. This contribution first sketches the behavioural problems explaining why retail investors do not always act upon their sustainability preferences and the potential role of the investment product distributor in bridging the gap between investors' values and actual investment choices. Against this background, the author offers a critical overview of sustainable finance provisions in the MiFID II and IDD investor protection frameworks and their relationship with the Sustainable Finance Disclosure Regulation and the Taxonomy Regulation
Expression and function of dipeptidyl peptidases IV, 8 en 9 : focus on endothelial cells and macrophages
No full textMulticenter interlaboratory study of routine systems for the susceptibility testing of temocillin using a challenge panel of multidrug-resistant strains
No full textAccurate susceptibility result of temocillin (TMO) is important for treating infections caused by multidrug-resistant Enterobacterales. This multicenter study aimed to investigate the performance of routine temocillin testing assays against Enterobacterales challenging strains. Forty-seven selected clinical isolates were blindly analyzed by 12 Belgian laboratories using VITEK® 2 (n = 5) and BD Phoenix™ (n = 3) automated systems, ETEST® gradient strip (n = 3), and disk (3 brands) diffusion method (DD; n = 6) for temocillin susceptibility using standardized methodology. Results were interpreted using EUCAST 2023 criteria and compared to the broth microdilution (BMD; Sensititre™ panel) method used as gold standard. Methods' reproducibility was assessed by testing 3 reference strains in triplicate. A total of 702 organism-drug results were obtained against 33 TMO-susceptible and 14 TMO-resistant isolates. Excluding Proteae species (P. mirabilis and M. morganii), the essential agreement rates were excellent (91.5-100%) for all MIC-based methods. The highest category agreement was achieved by ETEST® (97.5%) followed by VITEK® 2 (93.2%), disk diffusion (91.6%), and BD Phoenix™ (88.5%). BD Phoenix™ and paper disk diffusion overcalled resistance (11.5% and 6.8% of major discrepancies, respectively), while ROSCO tablets diffusion and VITEK® 2 generated higher very major discrepancies (7.1% and 4.2% respectively). Inter-assay reproducibility was unsatisfactory using recommended E. coli ATCC 25922 strain but was excellent with E. coli ATCC 35218 and K. pneumoniae ATCC 700603 strains. This interlaboratory study suggests that routine testing methods provide accurate and reproducible TMO categorization results except for Proteae species.Funding
The study was funded by a specifc budget allocated by the National Antibiogram Committee through Federal Public Service. The Belgian National Reference Center is supported in part by the Belgian Ministry of Social Afairs through a fund within the national health insurance system (INAMI-RIZIV).
Acknowledgements
We thank the staf of the laboratories who participated this study and the members of the Belgian National Antimicrobial susceptibility testing Committee for their scientifc and logistic support: Jerina Boelens, Laetitia Brassinne, Lucy Catteau
[Sciensano], Pieter-Jan Ceyssens, Julie Descy, Stefanie Desmet, Sarah Gils, Katrien Latour [Sciensano], Bénédicte Lissoir, Koen Magerman, Veerle Matheeussen, Cécile Meex, Hector Rodriguez-Villalobos, Sarah Vandamme [Universitaire Ziekenhuis Antwerpen], Anne-Marie Van den Abeele, Aline Vilain [Sciensano], Kris Vernelen, Ingrid Wybo [Universitaire Ziekenhuis Brussels], Harun Yaras [Belgian Antibiotic Policy Coordination Commission], Nicolas Yin [Laboratoire Hospitalier Universitaire de Bruxelles]
Comparison of a VLP‐based and GST‐L1‐based multiplex immunoassay to detect vaccine‐induced HPV‐specific antibodies in first‐void urine
No full textVaccine-induced human papillomavirus (HPV) antibodies originating from cervicovaginal secretions were recently shown to be detectable in first-void (FV) urine. This presents a novel opportunity for noninvasive sampling to monitor HPV antibody status in women participating in large epidemiological studies and HPV vaccine trials. With a view towards method optimization, this study compared the measurement of HPV antibodies in FV urine using a multiplex L1/L2 virus-like particles (VLP)-based ELISA (M4ELISA) with previously reported results using a glutathione S-transferase (GST)-L1-based immunoassay (GST-L1-MIA). We tested 53 paired FV urine and serum samples from 19- to 26-year-old healthy women, unvaccinated (n = 17) or vaccinated with either the bivalent or quadrivalent HPV-vaccine during adolescence (n = 36). HPV6/11/16/18 antibodies were measured using M4ELISA and compared with GST-L1-MIA results. Inter-assay and inter-specimen correlations were examined using the Spearman's rank test (rs). As expected, lower HPV antibody concentrations were found in FV urine than in serum. Vaccinated women had significantly higher HPV6/11/16/18 antibody levels in both FV urine and serum compared with those unvaccinated (M4ELISA; FV urine P = .0003; serum P <= .0001). HPV antibody levels in FV urine and serum showed a significant positive correlation (M4ELISA anti-HPV6/11/16/18, r(s) = 0.85/0.86/0.91/0.79, P <= .001). Despite assay differences, there was moderate to good correlation between M4ELISA and GST-L1-MIA (FV urine anti-HPV6/11/16/18, r(s) = 0.86/0.83/0.89/0.53, P <= .0001; serum anti-HPV6/11/16/18, r(s) = 0.93/0.89/0.94/0.75, P <= .0001). FV urine HPV antibody detection is comparable with both assays, further supporting this noninvasive sampling method as a possible option for HPV vaccine assessment. Approaches to improve the sensitivity and larger studies are warranted to determine the feasibility of FV urine for vaccine-induced HPV antibody detection.Industrial Research Fund of the University of Antwerp, Belgium, Grant/Award Number: PS ID 32387Pattyn, J (reprint author), Campus Drie Eiken,Bldg R2,Univ Pl 1, B-12610 Antwerp, Belgium.
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