162,935 research outputs found
Scientific Endeavors of A.M. Mathai: An Appraisal on the Occasion of his Eightieth Birthday, 28 April 2015
No full textA.M. Mathai is Emeritus Professor of Mathematics and Statistics at McGill University, Canada. He is currently the Director of the Centre for Mathematical and Statistical Sciences India. His research contributions cover a wide spectrum of topics in mathematics, statistics, physics, astronomy, and biology. He is a Fellow of the Institute of Mathematical Statistics, National Academy of Sciences of India, and a member of the International Statistical Institute. He is a founder of the Canadian Journal of Statistics and the Statistical Society of Canada. He was instrumental in the implementation of the United Nations Basic Space Science Initiative (1991–2012). This paper highlights research results of A.M. Mathai in the period of time from 1962 to 2015. He published over 300 research papers and over 25 books
D-branes, RR-fields and duality on noncommutative manifolds
No full textWe develop some of the ingredients needed for string theory on noncommutative spacetimes, proposing an axiomatic formulation of T-duality as well as establishing a very general formula for D-brane charges. This formula is closely related to a noncom4 mutative Grothendieck-Riemann-Roch theorem that is proved here. Our approach relies on a very general form of Poincaré duality, which is studied here in detail. Among the technical tools employed are calculations with iterated products in bivariant K-theory and cyclic theory, which are simplified using a novel diagram calculus reminiscent of Feynman diagrams
Phanuelus Caleb, Mungkung & Mathai, 2015, gen. nov.
No full textPhanuelus gen. nov. Caleb & Mathai Type species. Phanuelus gladstone sp.nov. Etymology. The proposed name is for the late Dr. G. J. Phanuel (Professor, Dept. of Zoology, MCC) who worked extensively on the spiders of Madras in the early 1960s. His work has been of great significance for later workers. The name is masculine in gender. Diagnosis. Small spiders characterized by short, very high cephalothorax, high and reduced thoracic region; abdomen round, nearly spherical. Leg III distinctly longer. Two RTAs (compared to usually two RTAs, sometimes with one RTA in Aelurillus, and two peaks, separated by a V or U shaped slit in Phlegra). Differs from Langona Simon in lacking a bunch of stiff hairs projecting from the base near RTA. Differs from Stenaelurillus Simon due to the absence of an anterior tegular apophysis. Embolus longer and thinner than in Stenaelurillus. Epigynum highly sclerotized, convex surface, with copulatory openings postero-laterally (whereas these are antero-median in Aelurillus, or hidden in circular grooves in Phlegra). Description. Spiders with small body (3-4 mm), carapace short and very high, short longitudinal fovea in a rounded, pit-like shallow depression in the centre just behind PLE line midway (Figs. 26, 32). Carapace widest at beginning of posterior slope; posterior slope very steep. PME closer to PLE than ALE. Clypeus vertical, moderately high (Figs. 28, 36). Male chelicerae without any tooth. Leg III longer than leg IV (Figs. 27, 37). Abdomen small, rounded with pairs of white spots arranged in the median, lighter lateral regions seen on females (Figs. 26, 33). Male palp with enlarged bulbus, tegulum leathery, embolus thin, two RTA, one long and bent at tip which is inconspicuous, other conspicuous, short and thick (Figs. 38, 39). Epigynum highly sclerotized, copulatory openings laterally placed apart, with meandering copulatory ducts (Figs. 40, 43, 44). Affinities. Species show clear affinity to subfamily Aelurillinae in genital structures and general morphology.Published as part of Caleb, John T. D., Mungkung, Soriephy & Mathai, Manu Thomas, 2015, Four new species of jumping spider (Araneae: Salticidae: Aelurillinae) with the description of a new genus from South India, pp. 1-18 in Peckhamia 124 (1) on page 7, DOI: 10.5281/zenodo.509297
Novel modulators of non-selective and selective autophagy
No full textPå samme måte som søppel dannes fra vårt daglige forbruk, produserer cellene i kroppen vår avfallsprodukter som transporteres til cellens resykleringsstasjon (lysosomet), hvor det brytes ned og gjenvinnes. Dette skjer via en prosess kalt autofagi, som involverer oppsamling av kargo/søppel i en vesikkel (et autofagosom) som smelter sammen med lysosomet. Autofagi oppreguleres ved stress, f.eks sult, men et basalt nivå av autofagi er viktig i alle celler for å beskytte mot sykdommer som kreft og nevrodegenerering.
Dannelsen av autofagosomer er vist å involvere en rekke proteinkomplekser og lipider, men de eksakte mekanismene involvert i regulering av autofagi er ikke kjent. I denne avhandlingen har Benan John Mathai og medarbeidere vist at proteinet HS1BP3 er en negativ regulator av autofagi. De fant at HS1BP3 inhiberer autofagi ved å hemme aktiviteten til det lipid-modifiserende enzymet PLD1, som igjen er viktig for å lage lipidet fosfatidsyre (PA) som er vist å være viktig for autofagi. Mathai fant at den regulatoriske rollen til HS1BP3 i autofagi er konservert i zebrafisk larver som uttrykker en fluoreserende markør for autofagi (LC3).
Selektiv nedbryting av spesialavfall (som dysfunksjonelle mitokondrier eller protein aggregater) ved autofagi krever spesielle autofagi-reseptorer (f.eks p62) som binder kargo. Benan John Mathai og medarbeidere har identifisert et «eat-me signal» på mitokondrier som gjenkjennes av slike autofagi reseptorer. Ved depolarisering av mitokondriene akkumulerer matriksproteinene NIPSNAP1 og NIPSNAP2 på overflaten av mitokondriene hvor de binder autofagireseptorer, som fører til nedbrytning av de ødelagte mitokondriene (mitofagi). NIPSNAP1/2-mediert mitofagi er avhengig av proteinene PINK1 og PARKIN, som begge er assosiert med Parkinsons sykdom. Mathai fant at zebrafisk larver som mangler Nipsnap1 har økt oksidativt stress, redusert nivå av dopaminerge nevroner og redusert bevegelse.
Dette doktorgradsarbeidet er et viktig bidrag til vår forståelse av de molekylære mekanismene involvert i regulering og dannelse av autofagosomer og gir innsikt i betydningen av disse prosessene i å hindre utvikling av sykdom
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Salt appetite
No full textUpdate of: R.S. Weisinger, D.P. Begg, M.L. Mathai, H.S. Weisinger Salt Appetite in: Encyclopedia of Neuroscience, 2009, Pages 445-45
Australia's nutrition transition 1961-2009: A focus on fats
No full textAlso see Erratum/Corrigendum: Shaan S. Naughton, Michael L. Mathai, Deanne H. Hryciw and Andrew J. McAinch (2015). Australia’s nutrition transition 1961-2009: a focus on fats - CORRIGENDUM. British Journal of Nutrition, 114, pp 997-997. doi:10.1017/S0007114515002913
Towards Learning Structure via Consensus for Face Segmentation and Parsing
No full textFace segmentation is the task of densely labeling pixels on the face according to their semantics. While current methods place an emphasis on developing sophisticated architectures, use conditional random fields for smoothness, or rather employ adversarial training, we follow an alternative path towards robust face segmentation and parsing. Occlusions, along with other parts of the face, have a proper structure that needs to be propagated in the model during training. Unlike state-of-the-art methods that treat face segmentation as an independent pixel prediction problem, we argue instead that it should hold highly correlated outputs within the same object pixels. We thereby offer a novel learning mechanism to enforce structure in the prediction via consensus, guided by a robust loss function that forces pixel objects to be consistent with each other. Our face parser is trained by transferring knowledge from another model, yet it encourages spatial consistency while fitting the labels. Different than current practice, our method enjoys pixel-wise predictions, yet paves the way for fewer artifacts, less sparse masks, and spatially coherent outputs
Does Generative Face Completion Help Face Recognition?
No full textFace occlusions, covering either the majority or discriminative parts of the face, can break facial perception and produce a drastic loss of information. Biometric systems such as recent deep face recognition models are not immune to obstructions or other objects covering parts of the face. While most of the current face recognition methods are not optimized to handle occlusions, there have been a few attempts to improve robustness directly in the training stage. Unlike those, we propose to study the effect of generative face completion on the recognition. We offer a face completion encoder-decoder, based on a convolutional operator with a gating mechanism, trained with an ample set of face occlusions. To systematically evaluate the impact of realistic occlusions on recognition, we propose to play the occlusion game: we render 3D objects onto different face parts, providing precious knowledge of what the impact is o
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