100,434 research outputs found
Cinquantaquattro, T. - Pescatori, G. (a cura di): 2. Regio I. Avella, Atripalda, Salerno. Collana Fana, Templa, Delubra. Corpus dei luoghi di culto dell’Italia Antica (FTD). Brossura; 23x30; ill. in bn; 136 pp.; 978-88-7140-502-5; € 28,00 (Edizioni Quasar, Roma 2013): recensione di Giovanni Mastronuzzi
No full texthttp://histara.sorbonne.fr/cr.php?cr=198
Boulders transport by catastrophic waves along the Ionian coast of Apulia (Southern Italy)
No full textSeveral tracts of the Ionian coast of Apulia (southern Italy) are characterized by large boulders, up to 80 t in weight, scattered
some meters above present sea level. The largest boulder is about 80 t in weight and slid for about 40 m from the mean sea level
up to about 1.8 m of altitude. Elongated boulders show a remarkably narrow range of orientation of the long axis as well as of
the imbrication axis, suggesting that they had been transported by a single catastrophic event, most likely a tsunami, connected
to a wave train approaching the coast from the South.
Stratigraphic, morphological and historical data suggest that this event occurred during the late Holocene. Conventional
radiocarbon age determination performed on Lithophag shells collected from a large boulder yielded a
calibrated age between 1421 and 1568 A.D. Then, the catastrophic wave train, probably a tsunami, could be a
local effect of the strong earthquake which hit southern Italy on December 5th, 1456. q 2000 Elsevier Science
B.V. All rights reserved
Castro. Capanne
No full textNotizia preliminare degli scavi archeologici condotti a Castro nella località Capanne, dove sono stati riportati alla luce quartieri di abitazione di età medievale e moderna e strutture di fortificazione risalenti ad epoca messapica
Castro, Castello Aragonese. Mostra Castrum Minervae tra Greci e Messapi
No full textPresentazione della mostra dedicata agli scavi archeologici condotti a Castro che hanno portato all'identificazione di un antico santuario dedicato ad Athena
Large boulder accumulations by extreme waves along the Adriatic coast of southern Apulia (Italy)
No full textThe Adriatic coast of southern Apulia (Italy) is marked by the presence of large boulder accumulations. Boulders are up to 8 t in weight and arranged either in small groups or rows composed of a few imbricated elements. The lower surface of some of the boulders is covered by biogenic encrustation which suggests that they were possibly carved from the mid or sublittoral zone and that they capsized during their transport. Other boulders, detached from the supratidal zone, have their surface affected by tilted rock pools. New horizontal solution pans are continually forming.
A detailed survey of a large boulder accumulation was carried out at Torre Santa Sabina. Direct observations were also made concerning the carving out and transportation of one single boulder during the severe storms in that area on January 4th, 2002 and on January 12th, 2003. Collated data from both the survey and the direct observations including some radiocarbon age determinations and hydrodynamic calculations suggest that the studied accumulation was due to the superimposed effects of one or two tsunami as well as of storm waves. Tsunami would be responsible for the detachment and transportation of the largest boulders, while storm waves may have been responsible for the carving out and transportation of the newer, smaller blocks and for moving once again the largest boulders. It was in this way that a typical boulder accumulation was produced.
The collated data suggest that two tsunami may have recently struck the Adriatic coast of southern Apulia. The first possibly took place on the Dalmatian coast as a result of the earthquake on April 6, 1667 which destroyed Ragusa (modern day Dubrovnik). The second tsunami would have accompanied the strong earthquake which took place in southern Apulia on February 20, 1743. (C) 2004 Published by Elsevier Ltd
Assessing the nutritional status of older individuals in family practice: Evaluation and implications for management
No full textL’archeologia del paesaggio costiero e la ricostruzione delle trasformazioni ambientali: gli insediamenti di Torre Santa Sabina e Torre Guaceto (Carovigno, Br)
No full textLetter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Sedimentological features of asbestos cement fragments in coastal environments (Taranto, southern Italy)
No full textAsbestos cement materials (ACMs) are widespread in coastal environments as result of illegal dumping activities. This study focuses on the Taranto area (Italy) in the Mar Grande basin within the northern sector of the Ionian Sea. The complex history of dumping building materials containing high amounts of ACM into the coastal zone, and the erosion, transport and deposition in Marechiaro Bay is a serious environmental hazard. An interdisciplinary research methodology defines the temporal dumping succession, and the erosional processes and phases, the diffusion of ACM, the mineralogical characteristics, and existing physical status of the ACM. A multiscale investigation was conducted. Results show that from 1992 to 2000 a significant increment of dumping operations have occurred. The current cliff has been subject to erosion and redeposition phases, developing a new beach composed of these polluted man-made sediments. The findings persuade the local authorities to close the beach requiring remediation interventions
CAR-T Therapy for Pediatric High-Grade Gliomas: Peculiarities, Current Investigations and Future Strategies
No full textHigh-Grade Gliomas (HGG) are among the deadliest malignant tumors of central nervous system (CNS) in pediatrics. Despite aggressive multimodal treatment - including surgical resection, radiotherapy and chemotherapy - long-term prognosis of patients remains dismal with a 5-year survival rate less than 20%. Increased understanding of genetic and epigenetic features of pediatric HGGs (pHGGs) revealed important differences with adult gliomas, which need to be considered in order to identify innovative and more effective therapeutic approaches. Immunotherapy is based on different techniques aimed to redirect the patient own immune system to fight specifically cancer cells. In particular, T-lymphocytes can be genetically modified to express chimeric proteins, known as chimeric antigen receptors (CARs), targeting selected tumor-associated antigens (TAA). Disialoganglioside GD2 (GD-2) and B7-H3 are highly expressed on pHGGs and have been evaluated as possible targets in pediatric clinical trials, in addition to the antigens common to adult glioblastoma – such as interleukin-13 receptor alpha 2 (IL-13α2), human epidermal growth factor receptor 2 (HER-2) and erythropoietin-producing human hepatocellular carcinoma A2 receptor (EphA2). CAR-T therapy has shown promise in preclinical model of pHGGs but failed to achieve the same success obtained for hematological malignancies. Several limitations, including the immunosuppressive tumor microenvironment (TME), the heterogeneity in target antigen expression and the difficulty of accessing the tumor site, impair the efficacy of T-cells. pHGGs display an immunologically cold TME with poor T-cell infiltration and scarce immune surveillance. The secretion of immunosuppressive cytokines (TGF-β, IL-10) and the presence of immune-suppressive cells – like tumor-associated macrophages/microglia (TAMs) and myeloid-derived suppressor cells (MDSCs) - limit the effectiveness of immune system to eradicate tumor cells. Innovative immunotherapeutic strategies are necessary to overcome these hurdles and improve ability of T-cells to eradicate tumor. In this review we describe the distinguishing features of HGGs of the pediatric population and of their TME, with a focus on the most promising CAR-T therapies overcoming these hurdles
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