117 research outputs found
The promise of N-acetylcysteine in the treatment of obsessive-compulsive disorder
No full textNo abstract available (Letter to the Journal
Contractual Limits to the Right to Strike in the Era of Crisis. The Italian Case with some Comparative Reliefs (France and the U.K.)
No full textThe economic crisis, the outsourcing of production, and globalization have produced significant changes in industrial relations and trade unions. Because of these changes, dissent – which is usually manifested through the exercise of the right to strike and the spontaneous actions – faces certain limitations set by trade union clauses, which have been recently introduced to govern industrial relations (e.g. industrial peace clauses and enforceability ones). In order to deal with the foregoing questions, the present paper provides an analysis of the notion of strike through supranational sources (Introduction, Silvia Donà, Università di Roma La Sapienza), followed by an examination of what is meant by “holding the right to strike” in Italy. The paper goes on to investigate the way this right is exercised (Section 1, Lilli Carollo, Università di Roma La Sapienza) and the clauses which have been devised to narrow down its exercise through the years (Section 2, Anna Rota, Università di Bologna), and concludes with an overview of the consequences arising from the violations of these clauses (Section 3, Marianna Russo, Università di Roma La Sapienza). With a view of better understanding the peculiarities of the Italian rules concerning the right to strike, a comparison will be provided with France and the UK (Marta Filippi, Università di Roma La Sapienza)
Organizzazione territoriale e produzioni ceramiche specializzate in area nord-lucana: Torre di Satriano e Ripacandida
No full textNella prima età del ferro, in Basilicata centro-settentrionale, come nel resto del mondo indigeno dell'entroterra della costa ionica, si avvertono forti segni di cambiamento rispetto all’epoca precedente: accanto allo sviluppo di sistemi insediativi già esistenti sono documentate, infatti, nuove forme di occupazione del territorio, in particolare nel corso dell'VIII sec.a.C. L’analisi della ceramica matt-painted e di altre produzioni specializzate, nonchè delle dinamiche insediative di due casi di studio (Torre di Satriano e Ripacandida) consente di comprendere dinamiche socio-economiche proprie delle comunità indigene ma anche di rintracciare la progressiva definizione e manifestazione di forme identitarie dei vari comprensori
Lo spazio del potere. La residenza ad abside, l’anaktoron, l’episcopio a Torre di Satriano.
No full textGap junction modulators: Prospects in bupropion cardiotoxicity
No full textBupropion, a multifaceted antidepressant, is associated with serious cardiotoxicity when misused. Recently, there has been a noticeable increase in cases of intentional poisoning and current therapeutic interventions for bupropion overdose remain insufficient. The cardiotoxic effects of the drug are primarily linked to its influence on cardiac gap junctions. Small-molecule drugs enhancing gap junction conductance, such as rotigaptide and danegaptide, present potential as antidotal agents. Testing these molecules under conditions of bupropion overdose could address the urgent need for innovative approaches to mitigate bupropion-induced cardiotoxicity
Characterizing pharmacobezoar formation: a descriptive analysis from VigiBase
No full textIntroduction: Pharmacobezoars are concretions of drugs that can persist within the gastrointestinal tract and can lead to mechanical obstruction and pharmacological toxicity. We aimed to provide a descriptive analysis of reported cases of pharmacobezoar in VigiBase, the World Health Organization global database of adverse event reports for medicines and vaccines. Methods: We conducted a descriptive analysis of all de-duplicated individual case safety reports related to pharmacobezoars recorded in VigiBase, from its inception in 1968 to March 2, 2025. In a subgroup analysis, we selected reports containing at least one Preferred Term related to drug overdose, misuse, or suicidal behavior to identify potential cases of acute intoxication. Results: A total of 632 individual case safety reports related to pharmacobezoars were analyzed. These primarily involved male patients (n = 318; 50.3%), with a median age of 60.0 years (IQR 43.0-71.0 years). Overall, 432 reports (68.4%) described serious adverse drug reactions. The most frequently involved drugs were carbidopa/levodopa (n = 148; 23.4%), quetiapine (n = 63; 10.0%), sucralfate (n = 46; 7.3%), nifedipine (n = 41; 6.5%), and acetylsalicylic acid (n = 40; 6.3%). The subgroup analysis included 158 reports related to acute intoxications, mostly involving female patients (n = 103; 65.2%), with a median age of 43.0 years (IQR 24.0-54.0 years). Almost all were serious (n = 156; 98.7%), with quetiapine, venlafaxine, ibuprofen, acetylsalicylic acid, paracetamol, and lorazepam most frequently reported. Discussion: The findings highlight the clinical severity and heterogeneous presentation of pharmacobezoars. Carbidopa/levodopa was frequently reported, possibly reflecting underlying conditions such as Parkinson disease with delayed gastric motility. The high prevalence of psychotropics underscores the need for targeted prevention in at-risk populations, particularly those with psychiatric comorbidities. Conclusions: While pharmacobezoars are rare, their association with serious and potentially fatal outcomes warrants increased clinical awareness. Early recognition and appropriate management may be particularly important in cases involving high-risk drugs
Il contratto di apprendistato nel d.lgs. 81 del 2015
No full textIl contratto di apprendistato nel D.lgs. 81/201
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