4,232 research outputs found
Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding
No full textRaw data that generated the graphs in the figures of the paper "Zanardi A, Barbariga M, Conti A, Vegliani F, Curnis F, Alessio M. Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding. Neurobiol Dis, 158: 105475, 2021" (DOI: 10.1016/j.nbd.2021.105474 ). These data were not included in the Supplementary Data associated to the pubblication in the web site of the journal
Atypical phenotype in a patient with ceruloplasmin mutations in the compound heterozygous state
No full textImages and dataset of densitometric analysis used for the generation of the figure 1 of the paper by Ravasi G, Pelucchi S, Canonico F, Mariani R, Piperno A. Atypical phenotype in a patient with ceruloplasmin mutations in the compound heterozygous state. Meta Gene. 2021, 29: 100905. doi.org/10.1016/j.mgene.2021.100905.
This paper is associated to the project "Blood-cerebrospinal fluid-barrie defect as gate for targeting by liver-directed ceruloplasmin gene replacement therapy in the rare disease aceruloplasminemia" supported by Italian Ministry of Health, with the grant RF-2018-1236671 to Massimo ALESSIO as principal investigator at the IRCCS-San Raffaele Hospital, Milano, Italy
Ceruloplasmin variants might have different effects in different iron overload disorders.
No full textRaw images and dataset of densitometric analysis used for the generation of the figure 1 of the paper by Pelucchi S, Ravasi G, Piperno A. Ceruloplasmin variants might have different effects in different iron overload disorders. J Hepatol. 2021, 75:1003-1004. doi: 10.1016/j.jhep.2021.05.005.
This paper is associated to the project "Blood-cerebrospinal fluid-barrie defect as gate for targeting by liver-directed ceruloplasmin gene replacement therapy in the rare disease aceruloplasminemia" supported by Italian Ministry of Health, with the grant RF-2018-1236671 to Massimo ALESSIO as principal investigator at the IRCCS-San Raffaele Hospital, Milano, Italy
Revisiting plane-generated gear tooth surfaces: a novel design perspective
No full textThe teeth of ordinary spur and helical gears are generatedby a (virtual) rack provided with planar generating surfaces. The resulting tooth surface shapes are a circle-involute cylinder in the case of spur gears, and a circle-involute helicoid for helical gears. Advantages associated with involute geometry are well known: in particular, the motion transmission function is insensitive to center distance variations, and contact lines (or points, when a corrective surface mismatch is applied) evolve along a fixed plane of action, thereby reducing vibrations and noise emission. As a result, involute gears are easier to manufacture and assemble than non-involute gears, and silent to operate. A peculiarity of their generation process is that the motion of the generating planar surface, seen from the fixed space, is a rectilinear translation (while the gear blank is rotated about a fixed axis):
the component of such translation that is orthogonal to the generating plane is the one that ultimately dictates the shape of thegenerated, envelope surface. Starting from this basic fact, we set out to investigate this type of generation-by-envelope process and to profitably use it to explore new potential design layouts. In particular, with some similarity to the basic principles underlying conical involute (or Beveloid) gears, but within a broader scope, we propose a generalization of these concepts to the case of involute surfaces for motion transmission between skew axes (and intersecting axes as a special case). Analytical derivations demonstrate the theoretical possibility of involute profiles transmitting motion between skew axes through line contact and, perhaps more importantly, they lead to apparently novel geometric designs featuring insensitivity of transmission ratio to all misalignments within relatively large limits. The theoretical developments are confirmed by various numerical examples
L'approccio ecologico allo studio della depressione durante la fase preadolescenziale
No full textLa depressione è il più comune problema psichiatrico durante la fase adolescenziale ed è associato ad una serie di importanti inabilità funzionali, suicidio e comorbilità psichiatrica. Adottando un approccio ecologico, il presente studio ha l’obiettivo di verificare i fattori protettivi e di rischio della depressione per i preadolescenti, legati alle relazioni familiari (sostegno, attività e conflitto), al senso di comunità a scuola e nella zona di residenza. E’ stato somministrato un questionario a 224 preadolescenti (52.2 % maschi) di età compresa tra gli 11 e i 14 anni (M = 12.9, DS = .90). Lo strumento somministrato comprendeva le scale relative al sostegno, alle attività e ai conflitti con i genitori, al senso di comunità a scuola e nella zona di residenza e alla depressione. I risultati hanno evidenziato come i principali fattori legati ai punteggi di depressione dei preadolescenti siano i conflitti (fattore di rischio) ed il sostegno (fattore protettivo) familiare. Lo studio conferma inoltre come il senso di comunità a scuola rivesta un importante ruolo protettivo nell’insorgenza di questi problemi, in particolar modo per i ragazzi che risultano avere una relazione problematica con i propri genitori
Uso di sostanze alcoliche e stili genitoriali: quale relazione nell'epoca di trasformazione della famiglia?
No full textObiettivo dello studio è di verificare quali siano le caratteristiche dello stile genitoriale (autorevole, autoritario, indulgente e negligente) che incidono sull’uso di alcolici in adolescenza. Il lavoro presentato è parte di una più ampia indagine denominata “Health Behaviour in School Aged Children” (HBSC), che è uno studio trans-nazionale promosso dall’Ufficio Europeo dell’Organizzazione Mondiale della Sanità. L’indagine viene svolta attraverso un questionario, messo a punto da un gruppo di ricerca internazionale, che indaga principalmente lo stato di salute ed i comportamenti ad essa legati. Il questionario è stato compilato da un campione di 2361 adolescenti (51.2% maschi) di età media pari a 15.88 anni rappresentativo degli adolescenti veneti che frequentano la seconda superiore. I risultati hanno messo in evidenza come il fenomeno “uso di alcolici” sia maggiormente diffuso nella regione (25.1%) piuttosto che nel resto d’Italia (19%). Le elaborazioni condotte tramite l’analisi della regressione logistica, hanno evidenziato come principali fattori determinanti di rischio dell’uso di alcolici siano il genere maschile, l’età e lo stile genitoriale negligente e autoritario. Sono inoltre discusse le possibili implicazioni rispetto all’utilizzo dei dati
Kriging with mixed effects models
No full textIn this paper the effectiveness of the use of mixed effects models for estimation and prediction purposes in spatial statistics for continuous data is reviewed in the classical and Bayesian frameworks. A case study on agricultural data is also provided
Framing Populist Radical Right Opposition to LGBTIQ+ Issues. Lega and Fratelli d’Italia’s Strategies on Social Media
No full textThis article proposes an analysis of discourse framing and addressing LGBTIQ+ issues within the social media communication of two examples of populist radical right-wing parties: Lega (the League) and Fratelli d’Italia (Brothers of Italy). The analysis focuses on the emergence of «antilgbtqism» within PRRPs’ communication on Twitter/X to assess whether it appeared occasionally or in a relatively persistent manner. Through this intra-comparative case study analysis, we aim to assess the saliency of (opposition to) LGBTIQ+ issues for PRRPs, and to build a model of investigation of (anti) LGBTIQ+ issues, expanding our knowledge of PRRPs and beyond this specific party family
Revisiting Generation and Meshing Properties of Beveloid Gears
No full textThe teeth of ordinary spur and helical gears are generated by a (virtual) rack provided with planar generating surfaces. The resulting tooth surface shapes are a circle-involute cylinder in the case of spur gears, and a circle-involute helicoid for helical gears. Advantages associated with involute geometry are well known. Beveloid gears are often regarded as a generalization of involute cylindrical gears involving one additional degree-of-freedom, in that the midplane of their (virtual) generating rack is inclined with respect to the axis of the gear being generated. A peculiarity of their generation process is that the motion of the generating planar surface, seen from the fixed space, is a rectilinear translation (while the gear blank is rotated about a fixed axis); the component of such translation that is orthogonal to the generating plane is the one that ultimately dictates the shape of the generated, envelope surface. Starting from this basic fact, we set out to revisit this type of generation-by-envelope process and to profitably use it to explore peculiar design layouts, in particular for the case of motion transmission between skew axes (and intersecting axes as a special case). Analytical derivations demonstrate the possibility of involute helicoid profiles (beveloids) transmitting motion between skew axes through line contact and, perhaps more importantly, they lead to the derivation of designs featuring insensitivity of the transmission ratio to all misalignments within relatively large limits. The theoretical developments are confirmed by various numerical examples
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