1,358,749 research outputs found
Il bello della geografia. Mostra cartografica, Roma, Laboratorio geocartografico “G. Caraci”, 2007
No full textTesti e scelta delle immagini a cura di C. Masetti: La sezione Atlanti; Civitates Orbis Terrarum 1 e 2; Atlante aerofotografico delle sedi umane in Italia; Le piante di Roma 1 e 2; La cartografia degli Stati Preunitari 1, 2 e 3
Successione Triassica
No full textnote illustrative delle unità litostratigrafiche e delle unità strutturali del Foglio Gemon
First-line treatment of acute lymphoblastic leukemia with pegasparaginase
No full textRiccardo Masetti, Andrea PessionPediatric Oncology and Hematology Unit “Lalla Seràgnoli”, University of Bologna, Bologna, ItalyAbstract: Acute lymphoblastic leukemia (ALL) accounts for almost 4000 cases annually in the United States, approximately two thirds of which are in children and adolescents. Treatment results of ALL have improved considerably in the past decade, due to an optimal stratification of patients and a rational use of different antileukemic agents among which L-asparaginase (L-ASNase) plays a fundamental role. This drug has been used in pediatric ALL chemotherapy protocols for almost 3 decades. In the 1970s and 1980s a chemically modified form of this enzyme called pegasparaginase (PEG-ASNase) was rationally synthesized to decrease immunogenicity of the enzyme and prolong its half-life. The different advantages of PEG-ASNase have been demonstrated in many clinical studies, the last of which underline the utility of this drug in front-line therapy of ALL. In this review, we discuss the pharmacological advantages and clinical potential of PEG-ASNase and its important use in first-line treatment of ALL.Keywords: pegasparaginase, acute, lymphoblastic leukemia, pegylatio
Schede di approfondimento in Allegati, CDRom
No full textSi tratta di diverse schede (trentacinque, per un totale di circa 77 pp.) - su tematiche relative a: Grandi viaggi, Geografia e geografi, Cartografia, Documenti e testimoninaze - inserite nelle Appendici , allegate in CD al volume di Ilaria Luzzana Caraci, "Al di là di Altrove" (Milano, Mursia, 2009)
Use of clofarabine for acute childhood leukemia
No full textA Pession, R Masetti, K Kleinschmidt, A MartoniPediatric Oncology and Hematology “Lalla Seràgnoli”, University of Bologna, ItalyAbstract: A second-generation of purine nucleoside analogs, starting with clofarabine, has been developed in the course of the search for new therapeutic agents for acute childhood leukemia, especially for refractory or relapsed disease. Clofarabine is a hybrid of fludarabine and cladribine, and has shown to have antileukemic activity in acute lymphoblastic leukemia as well as in myeloid disorders. As the only new antileukemic chemotherapeutic agent to enter clinical use in the last 10 years, clofarabine was approved as an orphan drug with the primary indication of use in pediatric patients. Toxicity has been tolerable in a heavily pretreated patient population, and clofarabine has been demonstrated to be safe, both as a single agent and in combination therapies. Liver dysfunction has been the most frequently observed adverse event, but this is generally reversible. Numerous Phase I and II trials have recently been conducted, and are still ongoing in an effort to find the optimal role for clofarabine in various treatment strategies. Concomitant use of clofarabine, cytarabine, and etoposide was confirmed to be safe and effective in two independent trials. Based on the promising results when used as a salvage regimen, clofarabine is now being investigated for its potential to become part of frontline protocols.Keywords: clofarabine, pediatric acute lymphoblastic leukemia, pediatric acute myeloid leukemi
The Masetti Trio
No full text8 x 10 inch photograph. The Masetti Trio. Handwritten on the back of the photograph: Gladys, we're sending you our picture in case you can show this to some tavern owner or agent and maybe get us a job. We would appreciate it very much. The address to write is 680 E. 117th St. Apt 105, Myrtle Fortune, Los Angeles, Cal. Say hello to Hamp for us. Thanking you in advance. -Sincerely The Masetti Trio300 dpi compressed jpg is displayed. Epson Expression 1640 XL Scanner, Epson TWAIN Pro, Adobe Photoshop 7.0, Archival Master file is a TIFF
Masetti y Bastidas, corresponsalía y compromiso
No full textEl argentino Masetti y el ecuatoriano Bastidas fueron los periodistas que realizaron la cobertura informativa en la Sierra Maestra, dos voceros del ejército libertador, dos convencidos de la causa de la revolución cubana. La policía de Batista asesino a Bastidas en La Habana y Masetti, luego del triunfo de la revolución, murió alzado en armas, en la montaña de Salta, su tierra nata
Masetti y Bastidas, corresponsalía y compromiso
No full textEl argentino Masetti y el ecuatoriano Bastidas fueron los periodistas que realizaron la cobertura informativa en la Sierra Maestra, dos voceros del ejército libertador, dos convencidos de la causa de la revolución cubana. La policía de Batista asesino a Bastidas en La Habana y Masetti, luego del triunfo de la revolución, murió alzado en armas, en la montaña de Salta, su tierra nata
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