138 research outputs found
Minimization problem on the Hardy-Sobolev inequality and on the Sobolev embedding for Lebesgue space with variable exponent
No full textExistence and nonexistence of ground state solution for semilinear elliptic equation involving Hardy-Sobolev critical exponent (Analysis on Shapes of Solutions to Partial Differential Equations)
No full textDecember 2002 3379 Hashizume Et Al.
No full textTropical instability waves (TIWs), with a typical wavelength of 1000 km and period of 30 days, cause the equatorial front to meander and result in SST variations on the order of 18--28C. Vertical soundings of temperature, humidity, and wind velocity were obtained on board a Japanese research vessel, which sailed through three fully developed SST waves from 1408 to 1108W along 28N during 21--28 September 1999. A strong temperature inversion is observed throughout the cruise along 28N, capping the planetary boundary layer (PBL) that is 1-- 1.5 km deep. Temperature response to TIW-induced SST changes penetrates the whole depth of the PBL. In response to an SST increase, air temperature rises in the lowest kilometer and shows a strong cooling at the mean inversion height. As a result, this temperature dipole is associated with little TIW signal in the observed sea level pressure (SLP)
Mapping XR Platforms: Analyzing Immersion from the Designer’s Perspective
No full textUnderstanding humans are the key to developing optimal design solutions for product-service systems. In this sense, the experiential approach is in line but might go beyond typical Human Centered Design (HCD) methods in that it focuses on generating positive experiences that contribute directly to human well-being. Extended Reality (XR) showed the potential to replicate or simulate experience as a whole and gained attention from design communities. XR platforms confused design practitioners due to their fast-advancing amounts and relevant experiences. Hence, this study introduced two surveys on XR platforms to clarify which experiences they could provide and when to implement them into HCD processes. Survey 1 categorized XR platforms according to their key attributes and mapped them into the Experience Matrix. Survey 2 invented two designer personas and a fictional project to analyze barriers and strategies to implement XR platforms into design processes. Eighty-eight XR platforms were categorized into nineteen clusters, where creation and simulation had the highest numbers. Regarding implementing XR in design practices, the cost is still the key concern and there's a trade-off between software cost and assets purchased for different types of designers.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Applied Ergonomics and DesignTeaching & Learning Service
Probing the universal role of Sec1/Munc18 proteins by mutagenesis of yeast Sec1
No full textThe Sec1/Munc18 (SM) family of proteins is essential for intracellular vesicle trafficking in eukaryotic cells. Sec1, the SM protein at the yeast plasma membrane, is required for membrane fusion leading to secretion and cell growth. Fusion of exocytic vesicles targeted to the plasma membrane occurs in two stages. The vesicle is first tethered to the membrane by a protein complex called the exocyst. Essential membrane-associated proteins known as the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) located on both the plasma membrane and the vesicle assemble together to form a stable four-helix bundle called the SNARE complex. In the second step, Sec1 binds to the assembled SNARE complex and there is fusion of the two membranes.
Sec1 has been shown to bind the SNARE complex, but the exact role and mechanism of Sec1 function remains unknown. In this study, site-directed mutagenesis was used to investigate the significance of highly conserved salt bridges in SM proteins and define the SNARE complex binding surface on Sec1 with data from random mutants studied by Yi-Shan Cheng and Jenna Hutton. In addition, Sec1 mutants with a novel phenotype were generated that may support a role for Sec1 in vesicle tethering.M.S.Includes bibliographical references (p. 64-68)
Relationship between variational problems with norm constraints and ground state of semilinear elliptic equations in R²
No full textThe version of record of this article, first published in Calculus of Variations and Partial Differential Equations, is available online at Publisher’s website: https://doi.org/10.1007/s00526-024-02710-y.In this paper, we investigate variational problems in R² with the Sobolev norm constraints and with the Dirichlet norm constraints. We focus on property of maximizers of the variational problems. Concerning variational problems with the Sobolev norm constraints, we prove that maximizers are ground state solutions of corresponding elliptic equations, while we exhibit an example of a ground state solution which is not a maximizer of corresponding variational problems. On the other hand, we show that maximizers of maximization problems with the Dirichlet norm constraints and ground state solutions of corresponding elliptic equations are the same functions, up to scaling, under suitable setting
Non-compactness phenomena on critical problems and related topics
No full textdepartmental bulletin pape
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