3 research outputs found
The heat shock stress response after brain lesions: Induction of 72 kDa heat shock protein (cell types involved, axonal transport, transcriptional regulation) and protein synthesis inhibition
No full textThe cerebral stress response is examined following a variety of pathological conditions such as focal and global ischemia, administration of excitotoxins, and hyperthermia. Expression of 72 kDa heat shock protein (Hsp70) and hsp70 mRNA, the mechanism underlying induction of hsp70 mRNA involving activation of heat shock factor 1, and inhibition of cerebral protein synthesis are different aspects of the stress response considered here. The results are compared with those in the literature on induction, transcriptional regulation, expression, and cellular location of Hsp70, with a view to getting more insight into the function of the stress response in the injured brain. The present results illustrate thai Hsp70 can be expressed in cells affected at various degrees following an insult thai will either survive or die as the brain lesion develops, depending on the severity of cell injury. This indicates that, under certain circumstances, synthesized Hsp70 might be necessary but not sufficient to ensure cell survival. Other situations involve uncoupling between synthesis of hsp70 mRNA and protein, probably due to very strict protein synthesis blockade, and often result in cell loss. Cells eventually will die if protein synthesis rates do not go back to normal after a period of protein synthesis inhibition. The stress response is a dynamic event that is switched on in neural cells sensitive to a brain insult The stress response is, however, tricky, as affected cells seem to need it, have to deal transiently with it, but eventually be able to get rid of it, in order to survive. Putative therapeutic treatments can act either selectively, potentiating the synthesis of Hsp70 protein and recovery of protein synthesis, or preventing the stress response by deadening the insult severity.Supported by grants from the “Fondo de Investigaciones Sanitarias” (96-2187 and 97-0490). Author MAS has a fellowship from the Spanish Ministry of Education and SciencePeer Reviewe
Pseudohallucinations in an Adolescent: Considerations for Diagnosis and Treatment in the Case of "Kate"
No full textHallucinations are usually considered a hallmark of severe psychopathology, most commonly psychotic or thought disorders such as schizophrenia or other organic brain syndromes. However, several studies describe '"non-psychotic hallucinations" occurring in children and adolescents who experience hallucinations without other core symptoms of true psychosis, such as the presence of a thought disorder, disorganized behavior, and pervasive dysfunction. Some authors describe the controversial subject of "pseudohallucinations," which appears to be more representative of conversion disorder symptoms rather than psychotic symptoms. We present a case of "Kate," a 16-year-old adolescent female who required psychiatric hospitalization for auditory hallucinations with secondary delusional thinking. She was initially given a diagnosis of psychotic disorder, not otherwise specified (NOS), and treated with an antipsychotic and an antidepressant. At outpatient follow-up, although Kate continued to endorse hallucinations and delusional thinking, her symptoms were not felt to be part of a true psychotic disorder. The hallucinations could be viewed as a product of extreme anxiety; a diagnosis of generalized anxiety disorder (GAD) was made, and Kate was maintained on the antidepressant and antipsychotic medications. However, this did not entirely explain Kate's symptoms. The consideration of "pseudohallucinations" as conversion disorder symptoms in the form of psychiatric symptoms was key to making an accurate diagnosis, predicting prognosis, and tailoring treatment for Kate and her parents. A total of 29 months of a combination of both cognitive-behavioral and psychodynamic treatment by the first author (MAS) included both weekly individual therapy and weekly therapy with her parents for the first 12 months, biweekly individual and parents therapy for the next eight months, and monthly individual sessions for the final nine months, during which Kate was 18 years old. During the initial course of treatment, the antipsychotic was tapered and discontinued without precipitating an exacerbation of symptoms. Symptoms continued to improve throughout treatment with both patient and parents. We discuss the differences between psychosis and “pseudopsychosis” and the reasons for making the distinction in this case. We also discuss the possible explanation for these "pseudohallucinations" in Kate and how treatment was tailored. Finally, we discuss the implications for diagnosis, prognosis, and treatment of this and similar cases of non-psychotic hallucinations
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ri savaBBav* gtuuv PUB*.
paut alto rvtuiw ate cu-ira-ir
! Impressions
rtBrsrSta-tisi tuts AS
OsSsirSas at stank ». st**,
Alt*. Cat.. -at*« last At'
IOITOIIAL »TA**-
ayM,rue
J. A. SgUtBB. Woataar
Fair loniRhl. Probable lair tjat-
ardajr, wllh heavy frost.
miOAT ■ DBCEMni.lt !». t»0-
Right and Wrong
By GEO. O. ALTNOW
Tae laSSSTUf susfj Brut W«-rkly.
stat sraa- atoralag nearly
thousand copies ol (ha Weakly Pato
Alias so ta leaalar aubstrrltasrs. Tata
Ja aat a windy riirulaMim manager'
Uousan'l. '■'j^-en house ad br aclael
sssa at lessi its
■sad readers for Ihe paper. All
advertisers, both dallj aad
asses'*, are npisssatsd la ihla psb-
llratloo. Ths paper consists of six-
(ssa Batsa aad aaah peas la fall of
tits latsraat No business taaa ran
•ford to oterlooh this weekly.
It aaa ear belief wbea we started
ths dally that tbe weeklr would la a
large ussaasra as side tracked. We
urets aatstakes la Mm, Tare are both
prospering logslber. Tbe i-atnbloi'd
dallr sad weeklr wakes a team too
strati ta be rwetsted. Every family
ant UklBK Ihn dallr Will surely takv
taa weeklr. It la oar atak lo boll
dowa ear weekly Hat lo actual par-
la* BUstarrlbers. White paper costs
aaaaar. aad tt takea a tot ot It n
prist sUtssa pages, to fay nothing
af Ubor aad pontage. Aar pereoa
aot slaking to lake taa weekly
arged (o aotlfy aa aad ws sill lake
pittarv la atriklaa ala name oal (be
• tlti- Ttstee are ao many who wast
It eaoiigb lo par lor It, (bat we do nut
a****, ta sirs awar a alatl* tae*.
All of tha eoptaa et lbs weekly will
as aaal thronih tba poetoffle*. Thl*
nasi til sa that tbe citta-aa et Palo
Alio should petition Ibe |Ov«rrimrnt
aar aa ultra fores of tsall tarrters.
Oar peetomrv Is as prosperous laat
tt la dallr biilcln-. OBt wllh mall that
eaaaot be delttered oa time. If laa
Basil carrier doea sot brim fttex Palo
Allan oa Saini-day, tt la because hs
aast asoeu -salt taaa ha uaald dellvsr
aad roar oooy Is rut-oslng snugly In
A tteckiBBB dag far water aad sot
■old. Tbe public dlaa for (old aad
jets— watered atock.
Ultle did the Virginia rabbit.
ibtak. after those football discus-
slots*, tbat Prssldaat Roosevelt would
look tbem up.
John D. Rockefeller Is s*tmelder-
lag a scheme for creating sad sadow-
1b. aa old age petwloa land Crowing Old will soon be wortb the while.
Tbe trial of Mtdsalsataa CoBm tor
hating at AbbbpoIIb Academr prom-
I tea about tbe asms outcome aa wbsa
crowd of sophomores tries a fresb-
bb for being a lire.
President Eliot of Harvard adto-
catas lbs sbolllloB ot football for
mas rasr. We fall to aas tba i
or this other than (o Iowa* laa
aaal aterage casualties for (he eea-
tgry.
A Chtrago professor declares
resale la a aure care for tbe graft
aril. How will be etplsla the effect
of grand opera oa Manager Conrled •
sdmls-doa prices? Aad oa tae sal-
tries ot foreign alngsrs*
Whea call tasaa reached IIS. Russell sags aot out of luil. called an
automobile, weal dowa to Wall afreet
aad la three hoars bad loaaed ost
116,600.060. No. dear reads-', ba
didn't (Its It away.
The PlllplBoa of Manila aata W.
J. Brrsa a reception aad parade
worthy of a caaaaarlna hero Tba
taaror dalltered a apeecb which had
iBdepeadeace u Ita teat, bat te hla
surprise. Mr BfTSB ccaasaled cabed-
leare lo tbe tovernment. This would
iceni to Indicate (hat the Filipinos
bats aothlaa to hope for—whea
evea Mr. Bryan advisee saDmlaatoa
lo law aod order.
mil Hlreeb of Chicago de-
clsrss tbst Use world aeede saae
laad ars. Ta thl* we aares- But
wbea was the time tbe earth didn't
need ibem* la (he orfclaal gardes.
perhaps.
All blowlsg ot bora* sad atmltar
iialsa will be allowed Is Cbtcago for
nlr fifteen mlaatae at the opennlg
ot tba new rear. This might work
varr well'|a Philadelphia, bnt. It Is
craeltr lo tbe average Cbkagoaa.
A I'enaartvaala man calls*] la a
number of friends Bad a brass baad
to celebrate tbe marriage of bta dl'
toreed wife. We had all too sooa
Buptona tbst ssth bruUlltj of oae
man toward another waa a thing of
tbe past.
In Ban Bernardino two drunkard.
wsrs seaieaeed to hear s faatseraace
lactate. At this tas srtsnaara broke
down completalr sad there were even
tears ta the }udge's eyes ss be read
(ba B.nii !„■(. iiui there was ao al
tsraa(s: tbe court "saw hla duty and
dose It."
Wbsa King Edward was yet Prlaee
of Wales aad tratsJIag la Belgium
a man fired a .hot at htm, aad was
captured. Testerday Ibe piiaoaei
waa tat aaaad aad enrolled la the sr
mr- This action would astro to In
dlcale tbat tbe author Mas hate forgives him for missing Edward
A Baata Rosa famllr l*fl Tester-
day ' for htkhlgaa asaes-tlag
prsssal when, a little after lbs open'
lag of (as aew rear. Us Lord shall
ba revealed ta (be thai is aalata.
wbo ars aot praaast at taal rsvela-
tlon will be lost.- In spile of this
the railroads hats aet advertised, (b*
place or (ta advents**-* for the loar-
AU sabarribera who are aot aatd
la advance are urged to sand. la
checks for tbetr taberrtptlons As
aaaa aa osr bookkeepert can do so,
Mils win bs sen! oal. Tbs New Tsar
aamber will be resaty ror dtstrtbu-
ttsaa aest Mitaasy eveslag. Do aot
fail to get tt Bead a doaen copies to
rear Meads aad astp to advertise
Palo Alta.
It essaaa aa tt tba college pre*.
steal* of lbs cousin were eying with
ascb other la their efforts to make
taa most sUartttag atataatsats regard-
tag the disposition ot the football
aaaa*. President lllot of Hart art
saad* lha laie-t effort. He pro-
i taat the gam* shall be forbid-
- aaa rear aa tbat las -boys"
Usse to ooBtlder aad re-
lair brutal conduct la the
L HONTF BREAD makes happy
Earte ft Co. tell It
w^CtU-aat-iiCatt-
The Dest, scion tl do {ton* Irritating* (Isr-nlclde.
Cosrsatsed to care daidruff
sad pretaBt hair from 1*111 sf out
or money rafuntled.
^utulawjunsalBC.
& saORVfeMi
PretsrlpUen Drsuisit
Career CnlrarsUy aad Kat-crssa
Christmas
Candles
Carittaai Mala Klitd He a.
Clriil.ti lute Mid Ik Ib.
(1 Ss. tsr Ik. ■
Ckrltlaai Faacy tlud Ik It.
McCrackcn's
IIS Ualraraltjr Aaa.
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mg; three block, from pctofflc,
tlil —a room,, T»k> and Ljtloo. unlur-
v'y- o,.h,d
nu«. ne.r tchool, UalurouS.it
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FOR RENT FOR SALE
COiufWl —Corner lot oa Uncoln aveaae. I0U
A*\rV\) ,.„-) spiarttdid reuldaace district. A
**t IACA —Corner tot oa sannjr aide of Web-
aPlUjU m.f ,tra»t. Hal IB Aa Ideal bSSSS
alta.
%O*\.S0 ~i toom cottage ia good location,
****** unfurnished A n«t bousa (or a
small tamily
3200;
JtOOO"
-Cood • -oases house ea Webster
mm. Choice locaUoa.
Choke realdeare lota aaar tae bust-
block (root Postoatce. Very good-
cheap at tbe price.
COC —6 room uuteroithed cottage in ftae
f**J|,
30
65
' iocattoa. Nice lawa aad tire.
—Maaaa ah.nfle cottage oa Vfcl-
villa Btenoe. Cat in; all improve-
iiifnt. Vacant Janusr*-* lat. Now is
lbe lime to secure thia aaa BaOaat-
—o room home on corner let near
University aseaoe, aalurnisbed
Small building (or .errant, ia rear
Inside furnishing splendid. A very
large and beautiful llvlag room wttb
art-place tntkri this boase rtpc-tally
desirflblc (or a homa.
—A targe tt room boeae, well fur-
niahed; fine location.
—Corner lot on the aiiutiy aide of
Brtaa a-trss*t.
la good lo-
i sxcctletBt
tsoardlag boeae for .tud.au
stOflC/t —' toom Bhlagle houae adjolntng
**}3yJv Ualteralir atsaae.
2800
—Largs boase aad barn oa prom,
nent corner of Un iters it r area tie:
beaullful grounds
Good bare ta
—Kew 3 room cottage oo lot job
-saa A eoay Kttle bceac ^*—
WEKXOWAMA* J~^
Who bought a SUBURBAN OHO-
CEST so aa to stabs hla llrtag aad
aapeasss while waiting three rears
for other propositloas to develop.
Tbe business has dose IM* ssd
WADE MONET BNOUOH TO BUT
AND PAT FOR SEVERAL OOOD
LOTa-
NOW THE OWNER MUST
LEAVE aad tae propsrty can be pur-
cbaaad AT VALUE of the HEAL BX-
TATfl aad btock. XMB U8 AT
ONCB
Co-Operative Land and Trust Company
O.ntn ot Evergrean Pars. Sunnyjide. Alba Park, Atnslto Place
203.305 University Avenue, Palo Alto, Cal.
San rraneiaco Office. 720 Market Street. Phone Front 31.
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WANTS
CLASSIFIED
MWCKlXA.VIOtH a.
F you want to
A-lvtrtts* In rtB-*wspa*>crs
Trfstro at giiytimc
im or arttte
B-lasaeeiifirstt^ipKr
I Sastseess atrset
Tr*~"**"-,u--
Stop and Think
The Mol.k. entire stock
must go ut onee. Greet
biff berffelas In every department. Goods fflven
away. Come In a.id sva*
how you can ffet isaic.
We want to turn what wc
do not ffive away Into
cash—quick. You must
•at. Why not get all you
can ror your money? Any
order will be delivered ror
IO cents.
BLACK'S
Skcc.». tt I. F. LUCE 27a-2l. Uhersii) A-niat
I'CRE HILK AND CREAM detlt-
ered dallr h* the Palo Alto Crveta-
ery. Pa taaa 71. e
ORDER the reliable Cardinal cigar,
al Slade and Krntr't cigar Hands, for
the holidays Boa of as *t a-j. Made
la Palo .Mm iS-Tt
' "BiiXlviT'BTN^ osvtifcaleu
redeenied. Too prtc-e Cbarlea
Coaklla. Tie aUrket street iwk
WANTKU Rwini sad Ixeird la
pritaie fatall* by rommg man Ad
drssB H„ aeri a.. Palo Alte.
ELDERLY MAN ttaald Uha eta.
plpyment: cars of hotws or row aad
I*b*t«I there work, for atoderate
wsgua. Apidr 1»* I'Bleersltr aeeaue.
i;-;t-:i*
MONbTT LOANED--O0
propertT. trull or iBi-gs
Mwsad AeAlsy. 411 Uadterstly ate..
• IT Market atrees, Saa rraaclsvo
It-Irac
THE ONLT PLACE ta gat aa ap
lo date rhtckra dlaner Kiind«> for
!• cssitB la st tas Palo Alto Hotel.
WASTE I*.-A leltabwC girl for gen-
eral houtetroTb. good coob: three ia
latinly P. O BOS A3- 3t*
WAST!!*-- G.--I hoy, urith wheel.
tot deliver j. Call at Siarilot-d Pbar-
mac*-. i.-i*7tfc
rtlR HALE—flood vaunt driving
mare, alao buggy aad harneee Utile
aaatl. J. B. Roealter. U*. Melville
ata. t>-lT~ltr
PALO ALTO ACADEMY
Par Boys sad Girla
I Spttot tessester bcfins Mfvoja,
Jaaaary a. iqoG Daj and evening
classes. Primary, grantniar, high
| school and basHtese courses. Pritate
or ctats instroctH-tn Terut. m.^le
3*3 Wa.nl> -I-ft i
FOR RENT—Two casaa-st roosas
to rent at 5 Las-en ttreet. Call or
adorn* Box ttX- Stanford I'mv-i-
aits, *7-y--
FOR RENT—Tbree boestbreomg
rtriiin.. central Iracatioa, tnnny aad
BsosJera lmBrovess>eatt Itiqeire jc*.
Lytioa avsase _____ It-t*-*
ROOMS AND BOARD taa* be bad
at very raaanaable rates at .10 Hgh
ei ll-l«*
LOST—A satall perse. cs*atasstai
sra. Rcturs 10 this ofacc. Rcwstd.
LA-RTT—Wateh aad chala: aaats of
owner oa chela Plader leave with
Co-oiteiBtltp Isiad A Trutt Co. aad
receive reward. iT-sl''
LOST—A slvBder Ugasts-vttae
caae, striped with white on one aide.
FtBder will be rewarded br leavlag
It at Ml a*atiratia street or by alvlna
It to B. C. Htodrvtt. .1-11*
JutaTJlaaw
FOUND—Oeat'a casta aaa locket
Otter may get sarae al it- I'Blrer-
alty Bvease by neylag for thl. ad.
nttf-jr*
MiacraX*^ruXatOt*s^
BOARD AND U1DOINO st tas
Palo Alto Hotel •• to t> psr w '
Hagle BBsala tt. II aaa tl n
anaday dinners $0 eeata. Doc flsr-
Cet a New Tesr'fl proBperlts
check of SlatklB. sag **sd tt to
yoar frtsad. It looks aa prettr
'as a ebsck for a thousand dollars, alt hough It atay sot be
gaits aa es*etMlre. if 704 s,a.r
la takea wbea you send us your order or your prusrtiptloa
Nothing la dlsneStsed here which
baa aot beea cerefnllr assayed or
teeled Tshes tint*, of roBIs*: co*U
nion.j. loo, bat II fiers.
People are rsplsUy learslsg that
(be dvoeadable store, aad the aas
of lowest prlrea la tbe
UNIVERSITY DRUG CO.
Ptatsrally Hall Bstldlag
aiaar bandBoaai oaee al a i-edne-
Hun Ib price. Hut wbelhrr It
Is Ire r»nu of Srs dollars, yoar
order win bsvs careiul sad
prompt ror*Mdtest.os. Coate sad
look at lbs aew view tsooka.
sesssssaaeeeasaaesaaeees'
B. 8. GIBSON
San Francisco
MtMiofigar and
Purchasing Agent
DAILY TRIPS
Ormcaet F. I- CaaxrM.Lf.-a
1':..-., attra saa
Prepare for Winter
Strcnjthfn tha Stonuch with Mi-o-n* Tablet*, .aid Keep Well—
Guargnteed by UiaSrarntty Drag Company.
This la lbe season abea anyone
wtteee stutaach la aaturally uvek er
who baa beea lajared by eatlag too
taat or too much, aboulg suvngtheti
It with Ml-o-na Ubleca.
If you bate tae l*e*t ayati-atoate of
iDdlc-stloa or *tua-arh irosMrt.
Bake baste to get rid of It now. *|*ae
hearty food sad Indoor life of winter
wtll sat s bardea oa thai *soor old
wotaach which stay weaken ll bryttma
beta
Ml-s>na tablets are aa uoa.ual
cosnblnsUoa of valBsMe sTtasartaai;
' plesaa.
aaent* that aessthe and Beut t
Htated meeou* Baeutbrsae sa
stomach. BtiBtnlate the aofai
*ad Btreagthea ths whole
aystem If yoa bate baa dark aa. i
lira***, ladlevettoei. heertbura, specks
taefoie Ihe ryee. •Jevpleeasaees backache, aad debility oe wsshBess. It
shows that you a**>d Ml-o-svs,
Ask tbe CuIi»t.ii. Drag Comymmy
to aaow rott the cuarantr*- they eiia
with eaeh in cent box of this reraedy.
Ml-o-aa costs aothlag an lev. It cure*
