84 research outputs found
Corrigendum to “Reliability assessment of generic geared wind turbines by GTST-MLD model and Monte Carlo simulation” (Renewable Energy (2015) 83 (222–233), (S0960148115003158), (10.1016/j.renene.2015.04.035))
No full textThe authors regret that the Order of Authors in this article published in November 2015 is incorrect. Thus, the objective of this Corrigendum is to re-establish the originally agreed Order of Authors, as described below. Order of Authors from published Article: Yan-Fu Li, PhD; Sebastien Valla; Enrico Zio, PhD. Corrected Order of Authors to implement with this Corrigendum: Sebastien Valla, Yan-Fu Li, PhD; Enrico Zio, PhD. The Corresponding author to contact for these changes are the Primary Author, Sebastien Valla (email below). The authors would like to apologise for any inconvenience caused
New Insights into the Link Between DNA Damage and Apoptosis
No full textSIGNIFICANCE:
When lesions are unrepaired or there are defects in the DNA repair system, DNA damage is often correlated to apoptosis. However, different kinds of lesions and different degrees of lesion severity can trigger numerous signaling responses.
RECENT ADVANCES:
DNA repair proteins involved in specific DNA repair pathways can modulate the function or activity of some apoptotic factors, further emphasizing the crosstalk between DNA damage and cell death.
CRITICAL ISSUES:
Here, we discuss the signaling networks that link DNA damage to apoptosis, and we focus on post-translational modifications, leading to crucial changes in protein behavior, following various kinds of DNA damage. Moreover, we analyze the existence of apoptosis-related functions of typical repair proteins, leading to diverse, often-overlapping, DNA damage responses.
FUTURE DIRECTIONS:
The better understanding of the regulation and the functionality of key DNA repair proteins, also involved in apoptosis regulation, has the potential of modulating the cell outcomes on DNA damage, particularly in the context of cancer treatment
New insights into the link between DNA damage and apoptosis
No full textSignificance: When lesions are unrepaired or there are defects in the DNA repair system, DNA damage is often correlated to apoptosis. However, different kinds of lesions and different degrees of lesion severity can trigger numerous signaling responses. Recent Advances: DNA repair proteins involved in specific DNA repair pathways can modulate the function or activity of some apoptotic factors, further emphasizing the crosstalk between DNA damage and cell death. Critical Issues: Here, we discuss the signaling networks that link DNA damage to apoptosis, and we focus on post-translational modifications, leading to crucial changes in protein behavior, following various kinds of DNA damage. Moreover, we analyze the existence of apoptosis-related functions of typical repair proteins, leading to diverse, often-overlapping, DNA damage responses. Future Directions: The better understanding of the regulation and the functionality of key DNA repair proteins, also involved in apoptosis regulation, has the potential of modulating the cell outcomes on DNA damage, particularly in the context of cancer treatment. Antioxid. Redox Signal. 19, 559-571. © 2013, Mary Ann Liebert, Inc
A new Tetranchyroderma species (Gastrotricha, Macrodasyida, Thaumastodermatidae) from the Canary Islands (Spain)
No full textShallow sublittoral sediment collected from Tenerife (Canary Islands, Spain) yielded several specimens of an undescribed thaumastodermatid gastrotrich species along with some specimens of Paraturbanella teissieri and one unidentifiable specimen belonging to the genus Crasiella. The paper deals with the description of Tetranchyroderma canariense sp. nov. The new species, which appears closely allied with T thysanogaster, Tetranchyroderma sp. 4 and Tetranchyroderma sp. 5 (Valbonesi & Luporini 1984), is characterized by: 1. a complete cuticular covering made up of tetrancres, that are larger on the head and rear trunk region; 2. caudal pedicles each made up of two adhesive tubes; 3. up to 10 anterior adhesive tubes; up to 20 ventrolateral adhesive tubes per side, and two clusters of ventral adhesive tubes of 4 tubes each, located in the posterior trunk region. This represents the first record of marine Gastrotricha from the Canary Archipelago and the second marine gastrotrich species from Spain
Diversity and dynamics of an interstitial Tardigrada population in the Meloria Shoals, Liguria Sea, with a redescription of Batellipes similis (Heterotardigrada, Batillipedidae)
No full textQuantitative samples of sediment for tbc study of the meiofauna were collected monthly beween March 1996 and February 1997 from a 7-m-deep site in tbc Meloria Shoals, Livorno Italy. In tbc Tuscan Shoals, 16 species of tardigrades were found belonging to tbc families Stygarctidae, Halechiniscidae, and Batillipedidac. Megastygarctides orbiculatus and Actinarctus doryPborus are reported for tbc first time in tbc Mediterranean Sea, and a redescription of Batillipes similis is proposed. Global density of . tbc Tardigrada population fluctuated between 8 ind./10 cm2 in May 1996 and 285 ind./10 cm2 in January 1997. The lowest valite of tbc Shannon-Wiener biodiversity index (H' = 1.09) was found in September 1996, whereas the highest score (H' = 2.46) was obtamed in March 1996. Pielou's evenness index (J) fluctuated between 0.40 and 0.88, values attamed in January 1997 and March 1996, respectively. The study confirms the notion that tbc organogenic detritus of the Shoals represents a very favourable environment for meiofauna) organisms in generai, and Tardigrada in particular
A Science Mapping Review of Human and Organizational Factors in Structural Reliability
No full textIn the structural safety field, it is widely acknowledged that human error is the major contributor to structural failure. Since Human and Organizational Factors (HOFs) are critical latent conditions that can lead to human errors and further structural failures, it is essential to study into HOFs in the building industry to prevent the occurrence of failures. In this research, a bibliometric review of the existing literature on HOFs influencing structural reliability was conducted and results have been visualized in science maps. Insights into the publication output and trend, the key topics and its evolvement over time, the publication sources, as well as the contributing academics and their collaborations have been gained from the science mapping review. Apart from this, HOFs were collected from literature, after which a meta-analysis has been performed to identify the critical factors for structural reliability. In conclusion, this review provides a holistic picture of the current status for studies concerning HOFs influencing structural reliability and outlines the possible critical HOFs identified by existing research.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Safety and Security ScienceApplied Mechanic
Applying Bayesian networks to model uncertainty in project scheduling
No full textPhDRisk Management has become an important part of Project Management. In spite
of numerous advances in the field of Project Risk Management (PRM), handling
uncertainty in complex projects still remains a challenge. An important
component of Project Risk Management (PRM) is risk analysis, which attempts to
measure risk and its impact on different project parameters such as time, cost and
quality. By highlighting the trade-off between project parameters, the thesis
concentrates on project time management under uncertainty.
The earliest research incorporating uncertainty/risk in projects started in the late
1950’s. Since then, several techniques and tools have been introduced, and many
of them are widely used and applied throughout different industries. However,
they often fail to capture uncertainty properly and produce inaccurate, inconsistent
and unreliable results. This is evident from consistent problems of cost and
schedule overrun.
The thesis will argue that the simulation-based techniques, as the dominant and
state-of-the-art approach for modelling uncertainty in projects, suffers from
serious shortcomings. More advanced techniques are required.
Bayesian Networks (BNs), are a powerful technique for decision support under
uncertainty that have attracted a lot of attention in different fields. However,
applying BNs in project risk management is novel.
The thesis aims to show that BN modelling can improve project risk assessment.
A literature review explores the important limitations of the current practice of
project scheduling under uncertainty. A new model is proposed which applies
BNs for performing the famous Critical Path Method (CPM) calculation. The
model subsumes the benefits of CPM while adding BN capability to properly
capture different aspects of uncertainty in project scheduling
A Systematic Approach to Improve Reliability of Storm Surge Barrier Closures
No full textCoastal defenses must be upgraded to combat increasing flood risk due to climate change and other factors. Storm surge barriers, large movable hydraulic structures that close temporarily during storm surges to prevent coastal floods, play a vital role in protecting estuaries. Due to the complexity of their risk analyses, important improvements are sometimes overseen. Our objective is to develop a systematic approach which is more likely to find these important improvements. We tested the method to three historic cases where important improvements were initially overlooked. We anticipate that our method can be applied to other safety systems with a large number of failure modes as well.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Hydraulic Structures and Flood Ris
New Guidelines for the Quality Control of Risk Analyses of Critical Hydraulic Structures
No full textThe efficacy of risk models and risk analyses critically hinges on sufficient model evaluation. Nevertheless, the usefulness for the intended purpose is rarely systematically assessed. Poor or even lacking model evaluation of the applied risk models and analyses also troubles the asset management of storm surge barriers in the Netherlands. In practice, obvious flaws, missing failure modes and use that deviates from the original purpose regularly lead to unpleasant surprises, unnecessary costs and avoidable risks.Here, we introduce new guidelines for the quality control during the development, testing, maintenance and usage of risk analyses of critical hydraulic structures.First responses among stakeholders are rather positive since the guidelines help modelers and analysts to better understand critics and independent reviewers to structure their comments. However, the efficacy of the guidelines itself also need rigorous evaluation in the coming years. This may prove challenging as the application of the guidelines may also reveal that the organizations that operation the storm surge barriers are currently insufficiently equipped for the rigorous quality control of risk models and risk analyses.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Hydraulic Structures and Flood Ris
A Copula-Based Bayesian Network to Model Wave Climate Multivariate Uncertainty in the Alboran Sea
No full textAn accurate estimation of wind and wave variables is key for coastal and offshore applications. Recently, copulas have gained popularity for modelling wind and waves multivariate dependence, since accounting for the hydrodynamic relationships between them is needed to ensure reliable estimations of the required design values. In this study, copula-based Bayesian networks (BNs) are explored as a tool to model extreme values of significant wave height (Hs), wave period, wave direction, wind speed and wind direction. The model is applied to a case study located in the Alboran sea, close to the Spanish coast, using ERA5 database. Extreme values of Hs are sampled using Yearly Maxima and concomitant values of the missing variables are used. K-means clustering algorithm is applied to separate the different wave components and a BN is built for each of them. The assumption of modelling the dependence between the variables using Gaussian copulas and the structure of BNs are supported with the d-calibratioson score. Fitted marginal distributions are introduced in the nodes of the BNs and their performance is assessed using in-sample data and the coefficient of determination. The BN models proposed present high performance with a low computational cost proving to be powerful tools for modelling the variables under investigation. Future research will include different locations and databases.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Hydraulic Structures and Flood Ris
- …
