170,187 research outputs found
Development of chitosan-based aerogels: a versatile approach for various applications
No full textV magistrskem delu prikazujemo razvoj kompozitnih polisaharidnih aerogelov na osnovi hitozana, pri čemer kot dodatna biopolimera uporabljamo pektin in ksantan. Osredotočamo se na vpliv razmerij med posameznimi polisaharidi, strukturne lastnosti in termično stabilnost nastalih polisaharidnih aerogelov. Takšni aerogeli so zaradi biokompatibilnosti, razgradljivosti in vsestranskih funkcionalnih lastnosti perspektivni za uporabo v različnih biomedicinskih aplikacijah.
Za pripravo pektin-hitozanskih in ksantan-hitozanskih aerogelov uporabljamo sol-gel sintezo, pri čemer spreminjamo volumenska razmerja uporabljenih polisaharidov. Nastale alkogele sušimo s superkritičnim ogljikovim dioksidom pod različnimi pogoji: pri 40 °C in 120 barih ob prisotnosti etanola na polindustrijski napravi UHDE ter 40 °C in 200 barih brez etanola na napravi Extrate X SFE 500. Dobljene vzorce podrobno karakteriziramo z različnimi metodami, kot so plinska adsorpcija, Fourierjeva transformacijska infrardeča spektroskopija (FTIR), tremogravimetrična analiza (TGA) in diferencialna vrstična kalorimetrija (DSC). Poleg tega izvajamo tudi teste nabrekanja, s katerimi preučimo obnašanje aerogelov v mediju fosfatnega pufra. Izbrane polisaharidne aerogele impregniramo z natrijevim diklofenakom in ovrednotimo vpliv impregnacije na strukturne in termične lastnosti.
Rezultati kažejo, da na končne lastnosti kompozitnih polisaharidnih aerogelov pomembno vplivajo tako razmerja polisaharidov kot tudi pogoji sušenja in prisotnost izbrane zdravilne učinkovine.This master’s thesis presents the development of composite polysaccharide aerogels based on chitosan, incorporating pectin and xanthan as additional biopolymers. The research focuses on the influence of the ratios between individual polysaccharides on the structural properties and thermal stability of the resulting aerogels. Due to their biocompatibility, biodegradability, and versatile functional properties, such aerogels are considered promising candidates for various biomedical applications.
Pectin-chitosan and xanthan-chitosan aerogels are prepared via sol–gel synthesis, varying the volume ratios of the polysaccharides used. The resulting alcogels are dried with supercritical carbon dioxide under different conditions: at 40 °C and 120 bar in the presence of ethanol using a semi-industrial UHDE apparatus, and at 40 °C and 200 bar without ethanol using the Extrate X SFE 500 system. The obtained samples are thoroughly characterized using several analytical techniques, including gas adsorption, Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). In addition, swelling tests are performed to investigate the behaviour of the aerogels in a phosphate buffer medium.
Selected polysaccharide aerogels are impregnated with sodium diclofenac, and the effect of impregnation on their structural and thermal properties is evaluated. The results demonstrate that the final properties of the composite polysaccharide aerogels are significantly influenced by the polysaccharide ratios, drying conditions, and the presence of the chosen active pharmaceutical ingredient
La messinscena wilsoniana del Martyre de Saint Sébastien
No full textAnalisi della regia di Robert Wilson, in rapporto al testo di D'Annunzio e alle scelte operate nel 1911, alla prima messa in scena
Mémoires Turcs, en l'Hôtel de Son Excellence, rue de Tournon, Fauxbourg S. Germain, Paris, 1743, 2 voll.
No full textL'edizione online del romanzo epistolare di C. Godard D'Aucour rientra nel progetto di una ricerca scientifica d'interesse nazionale (PRIN 2002) dal titolo "Temi e modelli d'Oriente nelle letterature occidentali", diretta da Loretta Innocenti. Il lavoro sui testi francesi dell'unità di Venezia è stato coordinato da Lucia Omacini
An usual presentation of cytochrome C-oxidase (COX) deficiency shows partial spontaneous reversion.
No full textClinical and biochemical aspects of carnitine deficiency and insufficiency: transport defects and inborn errors of beta-oxidation
No full textClinical and biochemical aspects of carnitine deficiency and insufficiency: Transport defects and inborn errors of βoxidation
No full textCarnitine is required for entry of long chain fatty acids into mitochondria where βoxidation occurs. Primary carnitine deficiency, due to a generic defect in cellular carnitine transport, exists in myopathic and systemic forms. Secondary carnitine deficiency may be due to multiplicity of inherited abnormalities, including deficiencies in carnitine palmitoyltransferase acyl-CoA dehydrogenases, electron transfer flavoprotein, and 3-ketoacyl-CoA-thiolase. The clinical features, diagnosis, and treatment of these conditions are described. © 1992 Informa UK Ltd
Bringing Certainty and Order Out of the Wilderness of Law
No full textThe codification of the French civil law represented the first significant initiative which provided the moral and intellectual impetus for systematic reorganization and reform of the law. The growing production of laws by the legislatures, together with the courts’ constant definition of the principles of law, has always constituted a massive problem in providing a service of certain and equal justice. The French model of codification was undoubtedly useful but it did not suffice, by itself, to preserve a coherent and accessible system of law. The experience of the last decades showed a proliferation of new sources of law (including multilevel systems of protection of fundamental rights) that increased the complexity of law on a more than proportional scale. In order to tackle the compelling need of certainty and order in the legal systems, the French codification approach had been developed and integrated with other simplifying and reorganizing tools. The different experiences are interesting under three profiles: a) the subjects dedicated to the function of simplifying and clarifying the law; b) the tools used to perform the function; c) the effects produced in the legal systems. The comparative analysis of the different experiences in Civil law and Common law countries reveals a major tendency to constitute independent bodies by initiative of a law experts elìte of lawyers, judges and academics. Generally, these bodies adopt a scientific method in order to produce shared documents which are supposed to represent a valid reference for all the legal operators. Most of the time there is no political influence on the process, contributing to preserve the authoritativeness of the body. Notwithstanding, the documents may be addressed to the parliaments with the purpose to enact law reforms through the legislative process. Out of these cases, the documents are supposed to have mere persuasive value but it is disputed how they affect the other sources of law when they are widely adopted by courts
Residual muscle cytochrome c oxidase activity accounts for submaximal exercise lactate threshold in chronic progressive external ophthalmoplegia
No full textThe data from histological, biochemical, and mitochondrial DNA (mtDNA) studies of muscle biopsies from 10 patients affected with chronic progressive external ophthalmoplegia (CPEO) were related to dynamic and metabolic parameters of incremental submaximal exercise. Maximum power output was reduced in all patients as compared to controls. Analysis of the venous lactate curve during exercise revealed a lactate threshold at exercise levels ranging from 40 to 50% of the predicted maximal power output. An earlier significant increase in lactate could be detected by calculating the mean δ lactate. Lactate values were inversely correlated with the cytochrome c oxidase (COX) activity of isolated muscle mitochondria. No relationship was found between lactate values and the number of ragged red fibers, or cytochrome c oxidase-negative fibers or the proportion of deleted mtDNA measured in muscle biopsy specimens. The discussion underscores the value of lactate kinetics in assessing skeletal muscle function, as well as the use of muscle COX levels to predict the effectiveness of wild-type complementation of deleted skeletal muscle mtDNA in in vivo contractile performance of CPEO subjects
The effects of robot-assisted gait training in progressive multiple sclerosis: A randomized controlled trial
No full textBackground: Gait and mobility impairments are common in progressive multiple sclerosis (MS), leading to reduced quality of life (QoL). Objective: In this randomized controlled study, we tested the effects of robot-assisted gait training (RAGT) and compared it to conventional physiotherapy, measuring walking ability, depression, fatigue, and QoL in patients with progressive MS and severe gait disability. Methods: Fifty-two participants (Expanded Disability Status Scale score 6-7) completed the study protocol. They received two sessions/week over 6 weeks of RAGT or conventional walking therapy. Outcome measures were Six-Minute Walk Test, Ten-Meter Walk Test, Timed Up and Go Test, Berg Balance Scale, Fatigue Severity Scale, Patient Health Questionnaire, and Short Form 36. They were performed pre-treatment, post-treatment, and at 3 months. Results: Walking endurance (p < 0.01) and balance (p < 0.01) were improved among those in the RAGT group. Positive effects on depression in both treatment groups were highlighted. However, only among those in the RAGT group was perceived physical functioning QoL increased. No significant effects on fatigue were found. Conclusion: RAGT is a treatment option in progressive MS patients with severe gait impairments to induce short-lasting effects on mobility and QoL
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