323,607 research outputs found
[Carlo Martinotti: the real discoverer of Martinotti's cells].
No full textThe cells of Martinotti are unique neurons of the cerebral cortex with ascending axons. Giovanni Martinotti (1857-1928), professor of anatomic pathology at the University of Bologna, has been claimed to be the discoverer of such cells. Nevertheless, no papers specifically concerning neuroanatomy have been found in his curriculum. The authors have been able to establish that Carlo Martinotti (1859-1918), a pupil of Camillo Golgi (1843-1926) was the legitimate discoverer of the nerve cells carrying his own name
Climate change, biodiversity loss and mental health: a global perspective
No full textClimate change can have various psychopathological manifestations which have been more actively addressed by scientific research only in recent years. Indeed, extreme weather events and environmental changes have been shown to be associated with a range of mental health problems. Following the destruction of ecosystems, biodiversity loss can cause mental distress and emotional responses, including so-called 'psychoterratic' syndromes arising from negatively felt and perceived environmental change. Studies investigating relationships between biodiversity and mental health reveal a complex landscape of scientific evidence, calling for a better understanding of this challenging issue. Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists
Scratch Wound Healing Assay
No full textCell migration is a crucial step for wound healing. Assays able to evaluate cell migration are very useful to evaluate in vitro wound healing. Scratch wound assay creates a gap in confluent monolayer of keratinocytes to mimic a wound. The protocol of scratch wound is based on few steps: cell culture preparation, scratch wound assay, data acquisition, and data analysis
Lo sprawl
No full textIl contributo presenta alcune riflessioni sul fenomeno dello sprawl, sottolineandone la diffusione negli Stati Uniti e poi in Europa. Evidenzia inoltre l'impatto ambientale e sociale del fenomeno, in particolare sul consumo di suolo e sullo stile di vita di chi va a vivere nello sprawl stesso. Illustra infine alcuni recenti recenti di insediamenti sostenibili, orientati cioè a un basso livello di emissioni e a un basso consumo di suolo
Honey exposure stimulates wound repair of human dermal fibroblasts
No full textHoney is widely used for treating burns, ulcers and wounds, but the mechanisms of action are poorly known and the product is mainly used as an antimicrobial. We have examined here the wound healing properties of honey on human fibroblasts, using an in vitro scratch wound healing model. Three kinds of widely used monofloral honeys were used, viz. acacia (Robinia pseudacacia), buckwheat (Fagopyrum sp.), and manuka (Leptospermum scoparium). Data displayed an increased wound healing activity in fibroblasts, but with different efficiency and mechanisms of action among honeys. The effects of acacia and buckwheat emerged in both scratch wound and chemotaxis assays, while the effect of manuka was significant but lower. The use of inhibitors indicated on the whole an essential role of cytosolic calcium, an important role of ERK and p38, and a secondary role of PI3K. Acacia and buckwheat, but not manuka, induced significant increases in the release of interleukin-4 (IL-4), IL-6, and IL-8, indicating a correlation between interleukin upregulation and wound closure efficiency. This is consistent with our previous findings suggesting a higher ability of acacia and buckwheat to activate keratinocyte reepithelialization, with respect to manuka honey. In conclusion, our data indicate that acacia and buckwheat honeys are particularly efficient in facilitating fibroblast wound closure activities, suggesting new therapeutic possibilities for this natural product
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