590 research outputs found
Das Bilanzstrafrecht im Lichte der US- und EU-Einflüsse
No full textTagungsband der Konferenz vom 4.-5. November 2016 in Tiflis, Georgie
Insiderhandel und Marktmanipulation – Europäische Vorgaben
No full textTagungsband der Konferenz vom 4.-5. November 2016 in Tiflis, Georgie
Die Europäisierung des georgischen Wirtschaftsstrafrecht – eine Einführung
No full textTagungsband der Konferenz vom 4.-5. November 2016 in Tiflis, Georgie
Supplemental material for Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker
No full textSupplemental Material for Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker by Alexandra Christine Graf, Gernot Wassmer, Tim Friede, Roland Gerard Gera and Martin Posch in Statistical Methods in Medical Research</p
Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker
No full text With the advent of personalized medicine, clinical trials studying treatment effects in subpopulations are receiving increasing attention. The objectives of such studies are, besides demonstrating a treatment effect in the overall population, to identify subpopulations, based on biomarkers, where the treatment has a beneficial effect. Continuous biomarkers are often dichotomized using a threshold to define two subpopulations with low and high biomarker levels. If there is insufficient information on the dependence structure of the outcome on the biomarker, several thresholds may be investigated. The nested structure of such subpopulations is similar to the structure in group sequential trials. Therefore, it has been proposed to use the corresponding critical boundaries to test such nested subpopulations. We show that for biomarkers with a prognostic effect that is not adjusted for in the statistical model, the variability of the outcome may vary across subpopulations which may lead to an inflation of the family-wise type 1 error rate. Using simulations we quantify the potential inflation of testing procedures based on group sequential designs. Furthermore, alternative hypotheses tests that control the family-wise type 1 error rate under minimal assumptions are proposed. The methodological approaches are illustrated by a trial in depression. </jats:p
Urwirbels Antlitz. Überlegungen zu der Möglichkeit einer kritischen Edition der Verdeutschung der Schrift von Martin Buber und Franz Rosenzweig und ein Versuch zu Genesis 1,1-5
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Rezension zu: Bartsch, Tillmann / Brandenstein, Martin / Grundies, Volker / Hermann, Dieter / Puschke, Jens / Rau, Matthias (Hrsg.): 50 Jahre Südwestdeutsche und Schweizerische Kriminologische Kolloquien
No full textRezension zu: Böse, Martin / Meyer, Frank / Schneider, Anne (Hrsg.): Conflicts of Jurisdiction in Criminal Matters in the European Union. Volume I: National Reports and Comparative Analysis
No full textSubjective stress in female elite athletes and non-athletes: Evidence from cortisol analyses
Get PDFStress response can be considered a consequence of psychological or physiological threats to the human organism. Elevated cortisol secretion represents a biological indicator of subjective stress. The extent of subjectively experienced stress depends on individual coping strategies or self-regulation skills. Because of their experience with competitive pressure, athletes might show less pronounced biological stress responses during stressful events compared to non-athletes. In the present study, the short version of the Berlin Intelligence Structure Test, a paper-pencil intelligence test, was used as an experimental stressor. Cortisol responses of 26 female Swiss elite athletes and 26 female non-athlete controls were compared. Salivary free cortisol responses were measured 15 minutes prior to, as well as immediately before and after psychometric testing. In both groups, a significant effect of time was found: High cortisol levels prior to testing decreased significantly during the testing session. Furthermore, athletes exhibited reliably lower cortisol levels than non-athlete controls. No significant interaction effects could be observed. The overall pattern of results supports the idea that elite athletes show a less pronounced cortisol-related stress response due to more efficient coping strategies
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