3,592 research outputs found
Six drawings by Martin Shields presenting one man\u27s view of beauty found in the
No full textSix drawings by Martin Shields presenting one man\u27s view of beauty found in the area around Marginal Way. Titled Marginal Ways, the drawings are of the Franklin Arterial, people of Portland\u27s Bayside neighborhood, Kennedy Park, Portland High School, the skateboard park, and a Congress Street apartment building before it was demolished after a fire
Brooke Shields Addresses FIT Graduates
No full text2015 Commencement Speaker: Brooke Shields, Actor, Author, and Entrepreneur
Application of similarity principles and turbulence research to bed-load movement
No full textTranslation of the Ph.D. thesis of A. Shields "Anwendung der Aehnlichkeitsmechanik und der Turbulenzforschung auf die Geschiebebewegung"
Legal issues of human shields
No full textThe paper focuses on analyzing whether the civilians involved in the hostilities as involuntary
human shields enjoy the same legal protection under the law as voluntary human shields. The
author looks at the differences between voluntary and involuntary human shields and the
aspect of direct and indirect participation in hostilities. The analysis is based upon
International Law and Criminal Law articles and interpretations concerning the notion of
human shields. In addition, multiple cases where the human shields were observed, were also
examined to understand the court practice on how the court deals with the law breaches in
contemporary armed conflicts
GASP: gapped ancestral sequence prediction for proteins
No full textBackground: the prediction of ancestral protein sequences from multiple sequence alignments is useful for many bioinformatics analyses. Predicting ancestral sequences is not a simple procedure and relies on accurate alignments and phylogenies. Several algorithms exist based on Maximum Parsimony or Maximum Likelihood methods but many current implementations are unable to process residues with gaps, which may represent insertion/deletion (indel) events or sequence fragments.Results: here we present a new algorithm, GASP (Gapped Ancestral Sequence Prediction), for predicting ancestral sequences from phylogenetic trees and the corresponding multiple sequence alignments. Alignments may be of any size and contain gaps. GASP first assigns the positions of gaps in the phylogeny before using a likelihood-based approach centred on amino acid substitution matrices to assign ancestral amino acids. Important outgroup information is used by first working down from the tips of the tree to the root, using descendant data only to assign probabilities, and then working back up from the root to the tips using descendant and outgroup data to make predictions. GASP was tested on a number of simulated datasets based on real phylogenies. Prediction accuracy for ungapped data was similar to three alternative algorithms tested, with GASP performing better in some cases and worse in others. Adding simple insertions and deletions to the simulated data did not have a detrimental effect on GASP accuracy.Conclusions: GASP (Gapped Ancestral Sequence Prediction) will predict ancestral sequences from multiple protein alignments of any size. Although not as accurate in all cases as some of the more sophisticated maximum likelihood approaches, it can process a wide range of input phylogenies and will predict ancestral sequences for gapped and ungapped residues alik
Computational identification and analysis of protein short linear motifs
No full textShort linear motifs (SLiMs) in proteins can act as targets for proteolytic cleavage, sites of post-translational modification, determinants of sub-cellular localization, and mediators of protein-protein interactions. Computational discovery of SLiMs involves assembling a group of proteins postulated to share a potential motif, masking out residues less likely to contain such a motif, down-weighting shared motifs arising through common evolutionary descent, and calculation of statistical probabilities allowing for the multiple testing of all possible motifs. Much of the challenge for motif discovery lies in the assembly and masking of datasets of proteins likely to share motifs, since the motifs are typically short (between 3 and 10 amino acids in length), so that potential signals can be easily swamped by the noise of stochastically recurring motifs. Focusing on disordered regions of proteins, where SLiMs are predominantly found, and masking out non-conserved residues can reduce the level of noise but more work is required to improve the quality of high-throughput experimental datasets (e.g. of physical protein interactions) as input for computational discovery
Reference to the index of the miscellaneous Launceston land deeds (1823-1854, of Shields, Heritage, Stackhouse & Martin, solicitors of Launceston.
No full textMiscellaneous documents from the office of Shields, Heritage, Stackhouse & Martin, solicitors of Launceston, mainly deeds of earlier solicitors Gleadow & Henty, etc., relating to land in the Launceston district, including property of Philip Oakden, Adam Beveridge, J. & W. Manifold and Robert Legge, etc., and claimed by R. Dry
Anwendung der Aehnlichkeitsmechanik und der Turbulenzforschung auf die Geschiebebewegung
No full textPh.D thesis of Shields, original version in German. This document is the basis of all modern sediment transport formulae, and develops the concept of bed shear stress
Shields-Darcy pipingmodel. Verschilanalyse met Sellmeijer en D-GeoFlow.
No full textHydraulic Structures and Flood Ris
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