4,529 research outputs found
Development of EB-PVD TBC'S : the role of deposition temperature and plasma assistance
No full textGas turbine manufacturers have achieved continuingly improved engine
efficiency and thrust-to-weight ratio by designing with increased Turbine
Entry Temperature (TET). The protection of High Pressure Turbine (HPT)
aerofoils with thin insulating ceramic coatings, referred to as Thermal Barrier
Coatings (TBC's), has emerged as the next key technology to allow for further
increases in TET. Electron Beam Physical Vapour Deposition (EB-PVD) is
today's most promising processing route for the manufacture of TBC's applied
on aerofoils.
The purpose of this work was to generate a sound understanding of the
relationship between the EB-PVD process and the structure of Zr02-
8wt%Y2O3 ceramic deposits, which could be exploited to achieve improved
TBC performance. In particular, the role of deposition temperature and the
potential benefits in using RF and DC plasma assistance of the EB-PVD
process were investigated, together with their influence on the erosion
performance of EB-PVD TBC's. The significance of particulate erosion as a
degradation mode is assessed under conditions representative of the HPT
environment. New explorable routes to achieve reduced thermal conductivity
of EB-PVD TBC's are identified.
It is shown that EB-PVD TBC's deposited at low temperature contain a
massive content of microscopic voidage (-50%) which is responsible for their
lack of thermal stability. The growth of EB-PVD TBC's at elevated deposition
temperatures is explained in terms of dynamic sintering, whereby diffusion
processes compete against the high rate arrival of vapour atoms to overcome
the spontaneous defectiveness of the atomic build up. Modelling of the gas
discharge physics has highlighted scope for improving the effectiveness of
plasma assistance in causing ceramic structural damage, capable of modifying
the coating thermal properties.
The erosion rate of EB-PVD TBC's is shown to be controlled by their degree
of plastic deformation upon particle impacts, which in turn depends on the
ceramic column diameter and inherent porosity
EB printing and varnishes
No full textPráce se zabývá přehledem současného stavu v oblasti tiskových barev a laků vytvrzovaných svazkem urychlených elektronů (EB). Zaměřuje se na složení a vlastnosti EB barev, zařízení pro jejich použití, principem vytvrzování a aplikačními možnostmi těchto barev. Dále poskytuje informace o dnešních trendech a vývoji této technologie a jejím využití v polygrafii.Katedra polygrafie a fotofyzikyDokončená práce s úspěšnou obhajobo
Radioligand Therapy of Prostate Cancer with a Long-Lasting Prostate-Specific Membrane Antigen Targeting Agent <sup>90</sup>Y‑DOTA-EB-MCG
No full textSeveral
radioligands targeting prostate-specific membrane antigen
(PSMA) have been clinically introduced as a new class of radiotheranostics
for the treatment of prostate cancer. Among them, (((R)-1-carboxy-2-mcercaptoethyl)carbamoyl)-l-glutamic acid
(MCG) has been successfully labeled with radioisotopes for prostate
cancer imaging. The aim of this study is to conjugate MCG with an
albumin binding moiety to further improve the in vivo pharmacokinetics.
MCG was conjugated with an Evans blue (EB) derivative for albumin
binding and a DOTA chelator. PSMA positive (PC3-PIP) and PSMA negative
(PC3) cells were used for both in vitro and in vivo studies. Longitudinal
PET imaging was performed at 1, 4, 24, and 48 h post-injection to
evaluate the biodistribution and tumor uptake of 86Y-DOTA-EB-MCG.
DOTA-EB-MCG was also labeled with 90Y for radionuclide
therapy. Besides tumor growth measurement, tumor response to escalating
therapeutic doses were also evaluated by immunohistochemistry and
fluorescence microscopy. Based on quantification from 86Y-DOTA-EB-MCG PET images, the tracer uptake in PC3-PIP tumors increased
from 22.33 ± 2.39%ID/g at 1 h post-injection (p.i.), to the peak
of 40.40 ± 4.79%ID/g at 24 h p.i. Administration of 7.4 MBq of 90Y-DOTA-EB-MCG resulted in significant regression of tumor
growth in PSMA positive xenografts. No apparent toxicity or body weight
loss was observed in all treated mice. Modification of MCG with an
Evans blue derivative resulted in a highly efficient prostate cancer
targeting agent (EB-MCG), which showed great potential in prostate
cancer treatment after being labeled with therapeutic radioisotopes
PSYCHOSOCIAL Guidance for social and healthcare professionals/ epidermolysis bullosa (EB) teams
No full textThis booklet is a summary of the Martin et al. (2019) Psychosocial recommendations for the care of children and adults with epidermolysis bullosa and their family: evidence based guidelines. It provides recommendations for health care professionals to optimise psychosocial well-being in EB
Quality of life evaluation in epidermolysis bullosa (EB) through the development of the QOLEB questionnaire: an EB-specific quality of life instrument
No full textP>Background Epidermolysis bullosa (EB) has a profound effect on quality of life (QOL); however, generic QOL assessments are poor indicators of the impact of EB. Objectives To develop a valid and reliable EB-specific QOL tool for use in measuring the effects of disease impact and interventions. Methods Open, nonstructured interviews were conducted with 26 patients with EB, along with 33 family members and 11 health professionals (70 individuals) for item generation. A pilot questionnaire was compiled, refined and distributed to 130 patients with EB. From the 115 returned questionnaires a principal axis factor analysis was undertaken producing a 17-item final questionnaire. Discriminative validity was assessed by differences in scores between EB subtypes. Content validity was assessed by expert ranking of items in terms of importance. Construct validity was evaluated by correlation with existing QOL tools. Test-retest reliability and internal consistency were evaluated. Factor analysis was performed. Results A 17-item questionnaire was developed: the QOLEB questionnaire. This gave distinguishing QOL scores to different EB subtypes, and correlated highly with existing QOL instruments. Conclusions The QOLEB questionnaire is the first EB-specific QOL measurement tool, and is a valid and reliable measurement tool for the quantification of QOL in patients with various subtypes of EB. In addition, the QOLEB has potential as a sensitive instrument to monitor QOL, and to identify dimensions of QOL as targets for interventions and research
NYSM, Albany: WTC, Martin Bellew
No full textDocument submitted by Robin Nagle, anthropologist for Sanitation Department, New York. Image in JPEG format. Photograph taken from social event held at The New York State Museum’s exhibition opening of The World Trade Center: Rescue Recovery Response.Photograph taken from New York State Museum, Albany, NY. of Martin Bellew speaking
NYSM, Albany: WTC, Martin Bellew
No full textDocument submitted by Robin Nagle, anthropologist for Sanitation Department, New York. Image in JPEG format. Photograph taken from social event held at The New York State Museum’s exhibition opening of The World Trade Center: Rescue Recovery Response.Photograph taken from New York State Museum, Albany, NY. of Martin Bellew speaking
MSC-EB support reduces liver injury biomarkers and increases survival.
No full text<p>Animals were treated with an MSC-EB, using a 3T3 fibroblast-based bioreactor (fibroblast-EB) and an acellular bioreactor (acellular-EB) as controls. (A) Serum biomarkers of liver injury, aspartate aminotransferase and alanine aminotransferase preceding and 24 hours after treatment with a MSC-EB (n = 5) or an acellular-EB (n = 3). Due to mortality, n = 1 in the acellular group after treatment. (B) Kaplan-Meier survival analysis of Gal-N administered rats treated with EBs. Time points of interventions are stated above survival plots. Each result for (B) was an independent experiment using different batches of MSCs. <i>P</i>-value determined by student's t-test analysis for panel (A). <i>P</i>-value determined by Log Rank Test for panel (B).</p
NYSM, Albany: WTC, Martin Bellew and man
No full textDocument submitted by Robin Nagle, anthropologist for Sanitation Department, New York. Image in JPEG format. Photograph taken from social event held at The New York State Museum’s exhibition opening of The World Trade Center: Rescue Recovery Response.Photograph taken from New York State Museum, Albany, NY. of Martin Bellew and another DSNY officer
NYSM, Albany: WTC, Martin Bellew and man
No full textDocument submitted by Robin Nagle, anthropologist for Sanitation Department, New York. Image in JPEG format. Photograph taken from social event held at The New York State Museum’s exhibition opening of The World Trade Center: Rescue Recovery Response.Photograph taken from New York State Museum, Albany, NY. of Martin Bellew and another DSNY officer
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