63 research outputs found
Introductietraject sleedoornonderstammen
No full textUit het onderzoek naar de gebruikswaarde van sleedoornselecties als onderstam voor pruim zijn sele cties naar voren gekomen die zeer perspectiefvol zijn . Deze hebben een groeikracht tussen die van VVA - 1 en St. Julien A (Van der Steeg et al, 2011 ). PPO is eigenaar van deze selecties. Vanuit de steenfruitsector bestaat hiervoor veel belangstelling . Men wil graag zo snel mogelijk bomen op deze onderstammen kunnen planten. Voordat éé n of meer selecties in de praktijk geïntroduceerd zouden kunnen worden, dien d en ze echter: - virusvrij gemaakt te worden - wettelijk beschermd te worden - vermeerderd te worde n Daarnaast wa s er de behoefte om ‘pilot s ’ op te zetten om de waarde aan de sector te demonstreren. Verder diende ook in het buitenland interesse ge wek t te worden voor het gebruik van deze selecties als onderstam voor pruim, kwets en mogelijk ook voor abri koos, perzik en nectarine. Dit is een grote potentiële afzetmarkt voor de onderstammen, waarmee de collectieve investering geld kan opleveren. In 2011 en 2012 is in een viertal projecten aan deze zaken invulling gegeven. In dit rapport worden de projecten beschreven
The ZML, PPD and JAZ protein subfamilies in grape.
No full text<p>(A) Phylogenetic analysis of grape ZML, PPD and JAZ proteins. Numbers above or below branches of the tree indicate bootstrap values. (B) Exon/intron structures of grape <i>ZML, PPD</i> and <i>JAZ</i> genes. Only the exons, represented by green boxes, are drawn to scale. Black lines connecting two exons represent introns. (C) The distribution of conserved domains within grape ZML, PPD and JAZ proteins. The relative positions of each conserved domain within each protein are shown in color. (D) Sequence logo of the TIFY (D) and Jas (E) domains from grape TIFY proteins.</p
Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP) — a prospective multicenter study
No full textBackgroundCommunity-acquired pneumonia (CAP) is a major global cause of death and hospitalization. Bacteria or community-acquired viruses (CARVs) cause CAP. COVID-19 associated restrictions effectively reduced the circulation of CARVs.ObjectivesThe aim of this study was to analyze the proportion of CARVs in adult patients with CAP from mid-2020 to mid-2023. Specifically, we aimed to compare the rate of influenza virus, SARS-CoV-2, and RSV detections in patients aged 18–59 years and ≥60 years.Study designWe analyze the proportion of 21 community-acquired respiratory viruses (CARVs) and three atypical bacteria (Bordetella pertussis, Legionella pneumophila, and Mycoplasma pneumoniae) in nasopharyngeal swab samples using molecular multiplex methods within the prospective, multicentre, multinational study of the German study Group CAPNETZ. We used stringent inclusion criteria throughout the study.ResultsWe identified CARVs in 364/1,388 (26.2 %) patients. In detail, we detected SARS-CoV-2 in 210/1,388 (15.1 %), rhino-/enterovirus in 64/1,388 (4.6 %), influenza virus in 23/1,388 (1.6 %) and RSV in 17/1,388 (1.2 %) of all patients. We detected RSV and influenza more frequently in patients ≥60 years, especially in 22/23 compared to the previous season. None of the atypical bacteria were detected.ConclusionsBeginning in 2023, we demonstrate a re-emergence of CARVs in CAP patients. Effective vaccines or specific antiviral therapies for more than two thirds of the detected viral infections are currently available. High detection rates of vaccine-preventable viruses in older age groups support targeted vaccination campaigns
The Minnesota Daily, April 23, 2001
No full textThis issue of the Minnesota Daily has been scanned from a microfilm copy of the original. It is representative of the physical copy it was scanned from, including duplicate pages, missing pages, or illegible pages. Paper copies of this issue of the Daily may also be held by the University of Minnesota Archives, and can be viewed by appointment.The Minnesota Daily. (2001). The Minnesota Daily, April 23, 2001. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/249158
Chronic mild stress-induced anhedonia in rats is coupled with the upregulation of inflammasome sensors: a possible involvement of NLRP1
No full textINTRODUCTION: NOD-like receptors containing pyrin domain (NLRP) are cytosolic receptors belong to innate immune system and function as sensing bodies for danger signals by forming inflammasome complex which in turn produces caspase-1-mediated interleukin (IL)-1β and IL-18 proinflammatory cytokines. Latest findings indicate that NLRP3 inflammasome mainly located in microglia cells in central nervous system (CNS) is linked to depression pathophysiology. However, another important CNS inflammasome, the neuronal NLRP1 inflammasome, has not been addressed in psychological stress or depression, yet. Therefore, the aim of the present study was to investigate the possible involvement NLRP1 inflammasome together with NLRP3 in chronic unpredictable mild stress (CUMS), a well-validated animal model of depression in rats. METHODS: Adult male Sprague–Dawley rats were divided into three groups: Control (treated with saline; non-stressed), CUMS (treated with saline), and CUMS + IMI (Imipramine; 10 mg/kg/day) (n = 6–8/group). In CUMS model, various stressors were applied for a total duration of six weeks. The treatments were daily administered via intraperitoneal (i.p.) route for the last three weeks of CUMS procedure. Anhedonia-like behaviors were assessed by sucrose preference test once in every two weeks throughout the experiment. At the end of the sixth week, rats were sacrificed and hippocampal brain tissues were collected for real-time PCR gene expression analysis of inflammasome components (NLRP1, NLRP3, ASC, and caspase-1) and inflammasome-dependent two proinflammatory cytokines (IL-1β and IL-18). RESULTS: CUMS-induced anhedonia in rats was coupled with upregulated mRNA levels of NLRP1, NLRP3, ASC, caspase-1, IL-1β, and IL-18 in hippocampus which were downregulated by chronic imipramine treatment. CONCLUSIONS: Our results suggest that the activation of not only NLRP3 but also NLRP1 inflammasome together may be involved in chronic stress-induced depression. Based on these results, further investigations are of great importance in order to understand the possible crosstalk between microglial (NLRP3) and neuronal (NLRP1) inflammasomes in depression and psychological stress
Protein id is Q8NG08
No full textThe files for protein Q8NG08 have been obtained in terms of the article, PHACT: Phylogeny-Aware Computing of Tolerance for Missense Mutation
Charge fluctuations and boundary conditions of biological ion channels : effect on the ionic transition rate
No full textA self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge fluctuations at the mouth are modeled as shot noise flipping the height of the potential barrier at the selectivity site. The resultant estimates of the conductivity of the ion channel are in good agreement with Gramicidin experimental measurements and they reproduce the observed current saturation with increasing concentration
Der Durchlauchtigen || Hochgebornen Fuersten vnd Herrn/ Her=||ren Johans Friedrichen des Mittlern/ vnd Her=||ren Johans Wilhelmen/ Gebruedere/ Hertzogen || zu Sachsen ... || Newe Hoffgerichts || Ordnung/ so jherlich zu vier vnterschiedenen || zeiten/ in jrer F. G. Stad Jhena besatzt/|| vnd wie es darinnen allenthal=||ben gehalten wer=||den solle.|| Anno M.D.LXVI.|| auffgericht.||
No full textVorlageform des Erscheinungsvermerks: [Jena: Donat Richtzenhan 1566
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