1,025 research outputs found
Intravenous uterine leiomyomatosis extending into the right heart
No full textMartin K. Oehler, Lino Scopacasa, Michael Brown, Guddati Kumar and James Edward
Problem Solving in Women's Health
No full textMargaret Rees, Sally Hope, Martin K. Oehler, Jane Moore and Polly Crawfordhttp://www.clinicalpublishing.co.uk/Book.asp?ID=10
Deciphering the molecular nature of ovarian cancer biomarker CA125
No full textThe ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning the existence of isoforms and the glycan moieties is presented. Mass spectrometry can overcome the pitfalls of a single detection/identification method such as antibody probing. Independent verification of CA125 identity in characterization studies will help establish a refined model of its molecular structure that will promote the development of new approaches for diagnosis, prognosis and therapy of ovarian cancer.Florian Weiland, Karina Martin, Martin K. Oehler and Peter Hoffman
N-Glycan matrix-assisted laser desorption/ionization mass spectrometry imaging protocol for formalin-fixed paraffin-embedded tissues
No full textLink to a related website: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rcm.7845, Open Access via UnpaywallAbstract not availableMatthew T. Briggs, Yin Ying Ho, Gurjeet Kaur, Martin K. Oehler, Arun V. Everest-Dass, Nicolle H. Packer and Peter Hoffman
Role of versican, hyaluronan and CD44 in ovarian cancer metastasis
No full textThere is increasing evidence to suggest that extracellular matrix (ECM) components play an active role in tumor progression and are an important determinant for the growth and progression of solid tumors. Tumor cells interfere with the normal programming of ECM biosynthesis and can extensively modify the structure and composition of the matrix. In ovarian cancer alterations in the extracellular environment are critical for tumor initiation and progression and intra-peritoneal dissemination. ECM molecules including versican and hyaluronan (HA) which interacts with the HA receptor, CD44, have been shown to play critical roles in ovarian cancer metastasis. This review focuses on versican, HA, and CD44 and their potential as therapeutic targets for ovarian cancer.Miranda P. Ween, Martin K. Oehler and Carmela Ricciardell
Serum HE4 as a prognostic marker in endometrial cancer - a population based study
No full textAbstract not availableDonal J. Brennan, Andreas Hackethal, Alex M. Metcalf, Jermaine Coward, Kaltin Ferguson, Martin K. Oehler, Michael A. Quinn, Monika Janda, Yee Leung, Michael Freemantle, ANECS Group, Penelope M. Webb, Amanda B. Spurdle, Andreas Obermai
CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1
No full textLink to a related website: https://cancerres.aacrjournals.org/content/canres/77/18/4823.full.pdf, Open Access via UnpaywallAbstract not availableWenying Zhu, Kate E. Jarman, Noor A. Lokman, Heidi A. Neubauer, Lorena T. Davies, Briony L. Gliddon, Houng Taing, Paul A.B. Moretti, Martin K. Oehler, Melissa R. Pitman, and Stuart M. Pitso
Transforming growth factor-beta-induced protein (TGFBI)/(Beta ig-H3): a matrix protein with dual functions in ovarian cancer
No full textTransforming growth factor-beta-induced protein (TGFBI, also known as βig-H3 and keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of physiological and pathological conditions including diabetes, corneal dystrophy and tumorigenesis. Many reports indicate that βig-H3 functions as a tumor suppressor. Loss of βig-H3 expression has been described in several cancers including ovarian cancer and promoter hypermethylation has been identified as an important mechanism for the silencing of the TGFBI gene. Our recent findings that βig-H3 is down-regulated in ovarian cancer and that high concentrations of βig-H3 can induce ovarian cancer cell death support a tumor suppressor role. However, there is also convincing data in the literature reporting a tumor-promoting role for βig-H3. We have shown βig-H3 to be abundantly expressed by peritoneal cells and increase the metastatic potential of ovarian cancer cells by promoting cell motility, invasion, and adhesion to peritoneal cells. Our findings suggest that βig-H3 has dual functions and can act both as a tumor suppressor or tumor promoter depending on the tumor microenvironment. This article reviews the current understanding of βig-H3 function in cancer cells with particular focus on ovarian cancer.Miranda P. Ween, Martin K. Oehler and Carmela Ricciardell
Proteomics of endometrial cancer diagnosis, treatment, and prognosis
No full textLink to a related website: https://digital.library.adelaide.edu.au/dspace/bitstream/2440/99849/2/hdl_99849.pdf, Open Access via UnpaywallThis review discusses the current status of proteomics technology in endometrial cancer diagnosis, treatment and prognosis. The first part of this review focuses on recently identified biomarkers for endometrial cancer, their importance in clinical use as well as the proteomic methods used in their discovery. The second part highlights some of the emerging mass spectrometry based proteomic technologies that promise to contribute to a better understanding of endometrial cancer by comparing the abundance of hundreds or thousands of proteins simultaneously.Parul Mittal, Manuela Klingler-Hoffmann, Georgia Arentz, Chao Zhang, Gurjeet Kaur, Martin K. Oehler, and Peter Hoffman
State of the art of 2D DIGE
No full textDifference gel electrophoresis enables the accurate quantification of changes in the proteome including combinations of PTMs and protein isoform expression. Here, we review recent advances in study design, image acquisition, and statistical analysis. We also compare DIGE to established and emerging mass spectrometric analysis technologies. Despite these recent advances in MS and the still unsolved limitations of 2DE to map hydrophobic, high molecular weight proteins with extreme pIs, DIGE remains the most comprehensive top-down method to study changes in abundance of intact proteins.Georgia Arentz, Florian Weiland, Martin K. Oehler, and Peter Hoffman
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