723 research outputs found
ACRMGroup/epitopes v1.0
No full text<p>Code and data for our paper on analysis of epitope discontinuity and conformation:</p>
<p><strong>B-cell Epitopes: Discontinuity and Conformational Analysis</strong></p>
<p>Saba Ferdous<sup>a,b</sup>, Sebastian Kelm<sup>c</sup> Terry S. Baker<sup>c</sup> Jiye Shi<sup>c,d</sup> and Andrew C.R. Martin<sup>a,*</sup></p>
<p><sup>a</sup>Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK;<br>
<sup>b</sup>Present address: Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, UK;<br>
<sup>c</sup>UCB Pharma, 216 Bath Road, Slough SL1 4EN, UK;<br>
<sup>d</sup>Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800 Shanghai, China<br>
<sup>*</sup>To whom correspondence should be addressed ([email protected] --or-- [email protected])</p>
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Synthesis of photoaffinity probes for the site-selective chemical modifications of the 5-HT3 receptor
No full textA Practical Introduction to the Simulation of Molecular Systems, Martin J. Field, Cambridge University Press, 1999; ISBN 0-521-58129-X. 325 pp. £50 (HB).
No full text1.012
No full textOne of the first achromatic instruments, the microscope has a heavy flat folding tripod base. The limb is attached to the pillar by a ball-and-socket joint of Ross design, and carries the body-tube, stage, condenser, and mirror. It comes with a mahogany carrying case and accessories which include a Goring engiscope. Dr. John Bunyan believed that this instrument was made by Andrew Ross and Hugh Powell, who had earlier worked for Pritchard. Signed: Andrew Pritchard, 162 Fleet Street, London
Early signs of neurobehavioral improvement after short-term continuous positive airway pressure in obstructive sleep apnea
No full textThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Commentary on: Ivana Rosenzweig, Martin Glasser, William R. Crum, Matthew J. Kempton, Milan Milosevic, Alison McMillan, Guy D. Leschziner, Veena Kumari, Peter Goadsby, Anita K. Simonds, Steve C.R. Williams, Mary J. Morrell. (2016) Changes in Neurocognitive Architecture in Patients with Obstructive Sleep Apnea Treated with Continuous Positive Airway Pressure EBioMedicine, Volume 7, May 2016, Pages 221-22
Modelling Molecular Structures, 2nd ed, by Alan Hinchliffe, Wiley, 2000. ISBN 0-471-48993-X; £34.95
No full text
Structural biology of moonlighting: lessons from antibodies
No full textProtein moonlighting is the property of a number of proteins to have more than one function. However, the definition of moonlighting is somewhat imprecise with different interpretations of the phenomenon. True moonlighting occurs when an individual evolutionary protein domain has one well-accepted role and a secondary unrelated function. The 'function' of a protein domain can be defined at different levels. For example, although the function of an antibody variable fragment (Fv) could be described as 'binding', a more detailed definition would also specify the molecule to which the Fv region binds. Using this detailed definition, antibodies as a family are consummate moonlighters. However, individual antibodies do not moonlight; the multiple functions they exhibit (first binding a molecule and second triggering the immune response) are encoded in different domains and, in any case, are related in the sense that they are a part of what an antibody needs to do. Nonetheless, antibodies provide interesting lessons on the ability of proteins to evolve binding functions. Remarkably similar antibody sequences can bind completely different antigens, suggesting that evolving the ability to bind a protein can result from very subtle sequence changes
Using and evaluating CASE tools : from software engineering to phenomenology
No full textCASE (Computer-Aided Systems Engineering) is a recent addition to the long line of
"silver bullets" that promise to transform information systems development, delivering
new levels of quality and productivity. CASE is particularly intriguing because
information systems (IS) practitioners spend their working lives applying information
technology (IT) to other people's work, and now they are applying it to themselves.
CASE research to date has been dominated by accounts of tool development,
normative writings (for example practitioner success stories) and surveys recording
IT specialists' perceptions. There have been very few in-depth studies of tool use,
and very few attempts to quantify benefits, therefore the essence of the CASE process
remains largely unexplored, and the views of stakeholders other than the IT specialists
have yet to be heard.
The research presented here addresses these concerns by adopting a hybrid research
approach combining action research, grounded theory and phenoinenology and using
both qualitative and quantitative data in order to tell the story of a system developer's
experience in using CASE tools in three information systems projects for a major UK
car manufacturer over a four year period. The author was the lead developer on all
three projects. Action research is a learning process, the researcher is an explorer.
At the start of this project it was assumed that the tools would be the focus of the
work. As the research progressed it became evident that the tools were but part of
a richer organisational context in which culture, politics, history, external initiatives
and cognitive limitations played important roles. The author continued to record
experiences and impressions of tool use in the project diary together with quality and
productivity metrics. But the diary also became home to a story of organisational
developments that had not originally been foreseen.
The principal contribution made by the work is to identity the narrow positivistic
nature of CASE knowledge, and to show via the research stories the overwhelming
importance of organisational context to systems development success and how the
exploration of context is poorly supported by the tools. Sixteen further contributions
are listed in the Conclusions to the thesis, including a major extension to Wynekoop
and Conger's CASE research taxonomy, an identification of the potentially
misleading nature of quantitative IS assessment and further evidence of the limitations
of the "scientific" approach to systems development.
The thesis is completed by two proposals for further work. The first seeks to
advance IS theory by developing further a number of emerging process models of IS
development. The second seeks to advance IS practice by asking the question "How
can CASE tools be used to stimulate awareness and debate about the effects of
organisational context?", and outlines a programme of research in this area
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