836 research outputs found
Dynamis, the Object of a Philosophical Medicine: An Epistemological Analysis of the Treatise On Ancient Medicine
No full textIn this study, we propose to analyze the concept of dynamis in the treatise On Ancient Medicine that is part of the Corpus Hippocraticum. We will study it inasmuch as it constitutes a core concept on which a particular epistemological relationship between philosophy and medicine is resolved. There is an extensive hermeneutical tradition that presents this writing as the birth of a scientific medicine detached from all kinds of philosophical reflection. For the author of the letter would seem to behave like an empiricist who seeks as a doctor to get radically rid of philosophy or, at least, that ancient medicine that founds his medical practice in the philosophical theory of the elements. However, despite the partial success of this interpretive tradition, we believe that it runs the risk of offering a fragmentary and incomplete reading of the new epistemological statute that the author seeks to assign to medicine. In our opinion, the author, far from trying to expel the philosophy of practice and medical research, integrates it into a new model of scientific explanation.Fil: Gargiulo, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras. Centro de Estudios de Filosofía, Ciencia y Epistemología; Argentin
Per le Occasioni: una lettera inedita di Montale ad Alfredo Gargiulo
No full textSi pubblica una lettera inedita di Eugenio Montale ad Alfredo Gargiulo del 6 aprile 1940. Si tratta della prima testimonianza di spiegazione delle Occasioni da parte dell'autore. La lettera è una risposta alle critiche di Gargiulo pubblicate sulla Nuova Antologia.Editon and commentary of an unpublished letter by Eugenio Montale to Alfredo Gargiulo (April 6, 1940) in which it is contained the first explanation by the author about the way Le occasioni have to be read
Per un profilo dell'anonimo autore dell'Athenaion Politeia pseudo-senofontea
No full textThis paper examines and discusses a number of relevant passages of the Pseudo-Xenophontic Constitution of the Athenians in order to outline a profile of its author that turns out to be slightly different from the one usually envisaged by scholars. In all likehood this person was an Athenian citizen and a shipowner, who was not so opposed to Athen's seapower as much as he was hostile to Athenian democracy. Especially important is Athenaion Politeia III 12-13 because, when he states that the atimoi in Athens are few, he is tacitly admitting that the democratic government is not guilty of wickedly abusing the political instrument of atimia against oligarchs, and this is as well an argument in favour of a not too late date of composition
Erratum to: Short-Term Exposure to Enriched Environment in Adult Rats Restores MK-801-Induced Cognitive Deficits and GABAergic Interneuron Immunoreactivity Loss
No full textThe original version of this article unfortunately contained a mistake. The name of author was changed from "Pascual Gargiulo" to "Pascual Ángel Gargiulo. © 2017 Springer Science+Business Media, LLCUniversidad Autónoma de Chil
AN INTEGRATED EVALUATION MODEL FOR SHAPING FUTURE RESILIENT SCENARIOS IN MULTI-POLE TERRITORIAL SYSTEMS
No full textIn the present paper an integrated evaluation procedure is considered, with the aim of evaluating the ecological and economic synergies within an environmental system. The case study chosen to test this procedure is the Monferrato Ovadese in the province of Alessandria (Piedmont, Italy). The territory, which includes almost 40 municipalities, was divided into a system of 11 clusters, that were treated as interactive poles of the territory itself. This integrated procedure uses a system of ecological and economic indicators. For landscape ecology, the indicators were introduced as coefficients, which predict the transformation scenarios of the environmental system under observation. For the economics, indicators were integrated through a Multicriteria Analysis in order to define a super-indicator, which may be interpreted as a measure of attractiveness of the poles inside the environmental system. The attractiveness was subsequently set as the critical parameter of a dynamical system represented by the mathematical model of a Lotka Volterra type, which simulated people flows within the territory. This study demonstrates how this novel evaluation procedure can be used to support the decision-making process in the choice of sustainable territorial and urban actions
A multilevel method to manage the complexity of the sustainable construction works
No full textThe purpose of the research described in the paper is a contribution to the definition of methods and tools for the management of sustainability in construction works, supporting decisions by the actors of the construction process involved in the decision making stages (i.e. public and private managers, designers, developers, policy makers).
The paper reports on the research, adopting a multi-scale and multilevel approach in a life cycle perspective, focused on the development of inductive, logical / operational guidelines. The author shows an original interdisciplinary way to manage the complexity of a case study, where to any alternative of operation are associated aspects/impacts/performances, described by indicators connecting the building with different territorial scales
A case of thoracic ectopia cordis
No full textOBJECTIVE: Ectopia cordis (EC) is a rare malformation (5-8 per million live births) characterized by an abnormal position of the heart. Based on the anatomical position it can be classified into cervical (3%), cervico-thoracic (<1%), thoracic (60%), abdominal (30%), and thoracoabdominal (7%). In the most common form the heart is partially or totally exposed on the surface of the thorax through an opening in the sternum and has an open pericardial sac. The exact etiology remain unknown, the mechanism is probably an association of genetic and environmental factors. In the early stages of embryonic development, the heart is positioned outside the chest. With the normal folding of the embryo, the heart passively assumes its final position inside the pericardial sac. During the fourth week of organogenesis, the lack of complete fusion of the lateral folds in the formation of the chest wall can cause the anomaly. Another possible mechanism is the rupture of the yolk and chorionic sac, which can lead to the formation of fibrous bands that disrupt the fusion in the midline of the chest wall. An alternative theory is the mutation of the bone morphogenetic protein (BMP2) gene that plays a vital role in heart formation and ventral body closure of the chest wall. EC can be an isolated lesion or be part of Cantrell’s pentalogy, associated with the thoraco-abdominal form. As in any fetal anomaly, if one abnormality is visualized a thorough investigation of all fetal systems should be carefully analyzed. EC can occur in conjunction with major chromosomopathies, especially trisomy 18 and Turner syndrome.
METHODS: A 28-year-old primigravida patient, referred to our hospital for a request of voluntary termination of an unwanted pregnancy. During the time of conception she was in therapy with an estrogen-progestin pill for contraceptive purposes, not effective maybe due to antibiotic therapy for odontopathy. Sonography has been useful to establish the gestational age and to diagnose the ectopia cordis. The patient underwent the therapeutic abortion procedure and a cytogenetic analysis of a flap of fetal skin was performed.
RESULTS: Our ultrasound examination revealed a single fetus with estimated age 17th weeks of gestation. Has been reported an isolated ectopia cordis with herniation of the heart from the right chest. The remaining fetal morphology appeared regular for the gestational age. Amniotic fluid was normal. Macroscopic anatomopathological examination resulted in a female fetus weighing 148 grams, ear cups with slightly low insertion, micrognathia and bilateral clubfoot. Examination of internal organs showed an incomplete anterior development of the diaphragm with consequent weakness and compression of the two lungs by the abdominal organs (in particular by the liver). It had been reported a complete ectopia cordis of the thorax with the heart rotated posteriorly and consequent slight torsion of the aorta and pulmonary artery. Macroscopic examination of the heart did not reveal additional malformations. A deletion of the short arm of chromosome 19 was detected in 19p13.3 band, containing the OMIM: TLE6-2-5, GNA11 and GNA15, S1PR4, NCLN.
CONCLUSIONS: EC is generally severe due to the frequent fetal growth restriction and high intrauterine and perinatal mortality rate. In most cases the newborn dies a few days after birth, usually by infection, major heart failure or hypoxemia. If there are no other severe cardiac malformations, surgical therapy mostly consists of covering the heart with skin, allowing some patients to survive into adulthood. Surgical treatment has a significant mortality rate. Early diagnosis with sonography is important to identify the main defect and its associated abnormalities, then counseling the patient on outcome and treatment options. EC generally has a poor prognosis, therefore termination of pregnancy should be recommended for families. Patients with thoraco-abdominal EC appear to have better outcomes, they show a survival of 45% after a mean follow-up of 5,6 years. While thoracic type has a higher mortality rate (83%). In order to establish the possible hereditary transmission, it is possible to do the Arrey- based Comparative Genomic
Hybridization test (CGH-array)to investigate the genome. There is no evidence that EC is a genetically transmitted disease, however genetic analysis can be useful to provide adequate counselling for families
Umbyquyra palmarum Gargiulo & Brescovit & Lucas 2018, gen. et comb. nov.
No full textUmbyquyra palmarum (Schiapelli & Gerschman, 1945) gen. et comb. nov. Figs 5C, 11, 12, 30 Cyrtopholis palmarum Schiapelli & Gerschman, 1945: 182, pl. IX. Cyrtopholis palmarum – Gerschman & Schiapelli 1973: 68, figs 1–5. — Schmidt 1993: 63, figs 68–69; 1997: 18, 149–150. Acanthoscurria palmarum – Schmidt 2003: 133, 142, figs 170–171. Diagnosis Males and females of U. palmarum gen. et comb. nov. differ from those of the other species by the strongly procurved fovea, like a half moon, delimitating the very long projection of the cephalic region (Fig. 5D) and male palpal bulb with well-developed A and SA keels (Figs 11A, 12 A–B). Female spermathecae with antero-medially excavated base and SR with very short ducts (Fig. 11D). Type material Holotype BRAZIL: ♂, Rondônia, Barão de Melgaço River, 11°45′11.3″ S, 60°56′24.1″ W, Sep. 1936, Vellard leg. (MACN 832). Additional material BRAZIL: Mato Grosso: 1 ♀, Chapada dos Guimarães, 15°27′46.9″ S, 55°44′59.2″ W, 1982. R.R. da Silva leg. (IBSP 107257); 2 ♂♂, Lucas do Rio Verde, PCH Canoa Quebrada, 13°04′24.9″ S, 55°55′11.1″ W, V. Azarias leg. (UFMT 0963, IBSP 167427); 1 ♂, Porto dos Gauchos, 11°21′57.1″ S, 57°28′48.1″ W, 31 Aug. 1962, H. Schulze leg. (IBSP 103628). Description Male (holotype, MACN 832) In life: according to Vellard (1945), reddish brown color with golden bristles covering all dorsal face of body. In ethanol: same color as U. paranaiba gen. et sp. nov. Total length 23. Carapace 8.8 long, 8.4 wide. Clypeus 0.2. AME 0.37 long, 0.35 wide; PME 0.25 long, 0.2 wide; ALE 0.25 long, 0.25 wide; PLE 0.35 long, 0.22 wide. Basal segment of chelicerae with 10 teeth. Labium 1.3 long, 1.8 wide, with 120 cuspules. Endites with 135–132 cuspules. Eye tubercle: 1.2 long, 2.0 wide. Stridulatory bristles with around 15 bristles on palp trochanter and 45 on leg I (Fig. 11 E–F). Palp: femur 8.5, patella 2.6, tibia 6.9, tarsus 2.3, total 20.3. Leg I femur 12.3, patella 4.5, tibia 11, metatarsus 9.6, tarsus 5.6, total 43. II 10.8, 3.5, 9, 9, 5.2, 37.5. III 9.6, 3.3, 8, 10.2, 4.4, 35.5. IV 12.3, 4, 11, 14.5, 5.6, 47.4. Spination: palp: femur d0-0-1app, tibia d0-1p-2p-2p-1app, v0-0-2p-0ap, p0-0-1-2-2-1-1-1-1- 1ap. Legs I femur d0-0-1app, tibia v1-0-1-1-1-1ap-1app, p1-0-1-0ap, metatarsus v-0-0-0-1ap. II femur d0-0-1app, tibia d0-1p-0-1p-1p-0-1app, v1-0-1-2-1ap, metatarsus v0-1-0-1-0-0-2ap-1app. III tibia v0- 1-1r-1apr-1ap-1app, p0-2-0-1ap, r1-1-1ap, metatarsus v1-1-0-1-2ap, p1-1-1-1-0-2ap, r0-1-0-1-1ap, r0- 1-0-1ap. IV tibia d0-1r-0-1r-0-1apr, v0-2-1-1r-1-1apr-2app, p0-1-1-0ap, metatarsus d0-1r-0app, v1- 1-1p-2r-1r-1-1p-2-1r-1p-1p-1r-2app-1ap, p0-0-1-0-1ap. Tibial apophysis of leg I: retrolateral branch well-developed with two strong distal spines and two median setae; prolateral branch weakly projected with distal spine and sub basal spine (Figs 11C, 12D). PLS basal, median and apical segments 2.3, 1.7, 2.0 long, respectively. Female (IBSP 107257) In ethanol: same as U. paranaiba gen. et sp. nov. Total length 40.0. Carapace 13.5 long, 12.5 wide. Clypeus 0.3. AME 0.35 long, 0.3 wide; PME 0.2 long, 0.2 wide; ALE 0.25 long, 0.45 wide; PLE 0.3 long, 0.3 wide. Basal segment of chelicerae with 11 teeth. Labium 2.1 long, 2.7 wide, with 125 cuspules. Endites with 140–142 cuspules pointed. Eye tubercle: 1.9 long, 2.4 wide. Stridulatory bristles as in male. Palp: femur 9, patella 5.3, tibia 6.9, tarsus 5.8, total 27. Leg I femur 13.4, patella 7.4, tibia 9.4, metatarsus 4.2, tarsus 5.4, total 39.8. II 12, 6.5, 6.5, 6.4, 7.2, 35.7. III 10.3, 7.2, 6.2, 9.1, 5.1, 37.9. IV 12.8, 6.3, 8.8, 10, 5.1, 43. Spination: palp: tibia v0-0-0-1p-1r-3ap, p0-0-1-1ap. Legs I femur d0- 0-1apr, tibia v0-1-2app, r0-1-0-3ap, metatarsus v-0-1ap, r0-1ap. II femur d0-0-1apr, tibia v0-1-0-3ap, p0-1-0-1ap, metatarsus v0-1-0-0-2apr. III femur 0-0-1apr, tibia v0-3-0-1app-1ap-1apr, p0-2-0-0ap, r1- 1-1ap, metatarsus d1-2p-0-2ap, v1-1r-1p-0-1ap, p1-1p-1p-1r-1r-1-1ap. IV femur 0-0-1app, tibia v0-1p- 2-1-1ap, 0-1-2ap, r0-1-0ap, metatarsus v1r-1r-2p-0-1p-1p-1p-1r-1r-1-2p-2ap, 0-0-1-0ap, p0-0-1-0ap, r0-1-0-1ap. PLS basal, median and apical segments 2.1, 2.6, 3.5 long, respectively. Spermathecae with RS rounded, apart from each other by approximately its own diameter (Fig. 11D). Distribution Brazil: states of Rondônia and Mato Grosso (Fig. 30). Natural history Jean Vellard, in 1945, collected two males in a rotten palm tree.According to the author, the spiders were very aggressive and no webs in the rotten palm tree, were was found.Published as part of Gargiulo, Fabio de F., Brescovit, Antonio D. & Lucas, Sylvia M., 2018, Umbyquyra gen. nov., a new tarantula spider genus from the Neotropical region (Araneae, Mygalomorphae, Theraphosidae), with a description of eight new species, pp. 1-50 in European Journal of Taxonomy 457 on pages 17-20, DOI: 10.5852/ejt.2018.457, http://zenodo.org/record/381791
Corrigendum to “Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischaemia” [Eur J Vasc Endovasc Surg 58 (1S) (2019) 1–109>] (European Journal of Vascular & Endovascular Surgery (2019) 58(1S) (S1–S109.e33), (S1078588419303806), (10.1016/j.ejvs.2019.05.006))
No full textThe authors regret that the name of one of the co-author has been incorrectly spelt. Dr. Mauro Garguilo should have been spelt as “Mauro Gargiulo”. The authors would like to apologise for any inconvenience caused
Antithrombotic treatment strategies after PCI – Authors' reply
No full textVranckx, P (reprint author), Hasselt Univ, Jessa Ziekenhuis, Fac Med & Life Sci, Dept Cardiol & Intens Care, B-3500 Hasselt, Belgium.
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