92 research outputs found
Lovell-Troy & Eickmann, Course Design For College Teachers
No full textConcern about the quality of undergraduate education at American colleges and universities has been mirrored by the publication of handbooks on teaching and instructional design, such as Course Design for College Teachers. According to Larry Lovell-Troy, Associate Professor of Sociology at Millikin University and principal author, this guide and workbook originated from ideas advanced first by Paul Eickmann at the Syracuse University Center for Instructional Development and then refined over more than a decade in a Workshop on Course Design and Teaching sponsored by the Great Lakes Colleges Association
Crystal Structure of the Borna Disease Virus Nucleoprotein
No full textAbstractBorna disease virus (BDV) causes an infection of the central nervous system in a wide range of vertebrates, which can fatally progress to an immune-mediated disease, called Borna disease. BDV is a member of the Mononegavirales, which also includes the highly infectious measles and Ebola viruses. The viral nucleoproteins are central to transcription, replication, and packaging of the RNA genome. We present the X-ray structure of the BDV nucleoprotein determined at 1.76 Å resolution. The structure reveals a novel fold, organized into two distinct domains, and an assembly into a planar homotetramer. Surface potential calculations strongly support an RNA binding model with the RNA wrapping around the outside of the tetramer, although a positively charged central channel in the tetramer could fit single-stranded RNA in an alternative binding mode. This first structure of an RNA virus nucleoprotein provides a paradigmatic model for RNA packaging and replication of single-stranded RNA viruses
Emerg Infect Dis
No full textInfluenza viruses, including highly pathogenic avian influenza virus (H5N1), could threaten blood safety. We analyzed 10,272 blood donor samples with a minipool nucleic acid amplication technique. Analytical sensitivity of the method was 804 geq/mL and 444 geq/mL for generic influenza primers and influenza (H5N1) subtype-specific primers. This study demonstrates that such screening for influenza viruses is feasible
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No full textInnovative Sicherungstechnik mit optischen Systemen
No full textOptische Sensoren werden im Schienenverkehr bislang für Anwendungen ohne oder mit nur geringer Sicherheitsrelevanz verwendet. Der Artikel beschreibt Anwendungsbereiche für den möglichen Einsatz optischer Sensoren im Schienenverkehr für höhere Sicherheitsrelevanz. Anhand eines Demonstrators, der die Einsatzfähigkeit optischer Systeme für unterschiedliche Funktionen an Bahnübergängen aufzeigen soll, werden die Aspekte Sicherheit, Verfügbarkeit, Zuverlässigkeit, betriebliches Umfeld und Kostenstrukturen beschrieben. Dabei wird die Frage der zunehmenden Sicherheitsrelevanz von der Funktion „Anrufen“ bis „Gefahrenraumfreimeldung“ thematisiert. Das Thema „Bahnübergang“ bietet auch einen Anwendungsbereich für Innovationen auf Basis kostengünstiger Technologien, die möglicherweise zu einem effizienteren Betrieb der Schieneninfrastruktur beitragen können
Genetic Stability of a Tick-Borne Encephalitis (TBE) Virus Strain used for the Production of a TBE Vaccine
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