218 research outputs found
Supplemental material for Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in <i>Bmpr2</i>-deficient mice
No full textSupplemental material for Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice by Alexi Crosby, Mark R. Toshner, Mark R. Southwood, Elaine Soon, Benjamin J. Dunmore, Emily Groves, Stephen Moore, Penny Wright, Katrin Ottersbach, Cavan Bennett, Jose Guerrero, Cedric Ghevaert and Nicholas W. Morrell in Pulmonary Circulation</p
StratosPHere 2: study protocol for a response-adaptive randomised placebo-controlled phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2
No full textBackground. Pulmonary arterial hypertension is a life-threatening progressive disorder characterised by high blood pressure (hypertension) in the arteries of the lungs (pulmonary artery). Although treatable, there is no known cure for this rare disorder, and its exact cause is unknown. Mutations in the bone morphogenetic protein receptor type-2 (BMPR2) are the most common genetic cause of familial pulmonary arterial hypertension. This study represents the first-ever trial of treatments aimed at directly rescuing the BMPR2 pathway, repurposing two drugs that have shown promise at restoring levels of BMPR2 signalling: hydroxychloroquine and phenylbutyrate.
Methods. This three-armed phase II precision medicine study will investigate BMPR2 target engagement and explore the efficacy of two repurposed therapies in pulmonary arterial hypertension patients with BMPR2 mutations. Patients will be stratified based on two BMPR2 mutation classes: missense and haploinsufficient mutations. Eligible subjects will be randomised to one of the three arms (two active therapy arms and a placebo arm, all plus standard of care) following a Bayesian response-adaptive design implemented independently in each stratum and updated in response to a novel panel of primary biomarkers designed to assess biological modification of the disease.
Discussion. The results of this trial will provide the first randomised evidence of the efficacy of these therapies to rescue BMPR2 function and will efficiently explore the potential for a differential response of these therapies per mutation class to address causes rather than consequences of this rare disease
Faculty Opinions recommendation of Prognostic Value of Follow-Up Hemodynamic Variables After Initial Management in Pulmonary Arterial Hypertension.
No full textFaculty Opinions recommendation of Upfront combination therapy reduces right ventricular volumes in pulmonary arterial hypertension.
No full textThe genetics of chronic thromboembolic pulmonary hypertension: no longer a stab in the dark
No full textPhysician associates: a solution for healthcare shortages or a colonial throwback?
No full textNo abstract available
Chronic thromboembolic pulmonary hypertension: time for research in pathophysiology to catch up with developments in treatment
No full textSociocultural--Geospatial Anthropological Portal (SC-GAP): Enhanced Sociocultural Understanding Through Crowdsourced Service Member Narratives
No full textThe article of record as published may be found at http://dx.doi.org/10.1016/j.promfg.2015.07.533Despite the Department of Defense’s (DoD) many investments directed toward developing and fielding programs designed to
advance sociocultural knowledge, the DoD nonetheless lacks a shared repository in which all entities can aggregate, visualize,
and share sociocultural data across the enterprise. A gap analysis of DoD’s desired and actual states of achieving and
implementing a sociocultural understanding reveals three main shortcomings: a data gap, a repository gap, and a collaboration
gap. As a consequence, we created a proof of concept, enterprise solution for DoD that bridges the overall sociocultural gap by
harnessing the overlooked and untapped potential of today’s deployed DoD service members, who over the course of their daily
duties, are exposed to various populations’ cultures. Service member observations and interpretations of service members’
interactions form an untapped set of operationally relevant sociocultural data. The existing wellspring of sociocultural
information needs only be collected and indexed using a framework derived from the Five Operational Culture Dimensions
model. Residing on a geodatabase and interfaced via a custom multi-client supported web-based Geographic Information System
(GIS), this framework integrates the collected data comprised of service member narratives with the greater Joint Force thereby
creating a dynamic and collaborative sociocultural living repository. Combining an anthropologically sound framework that is
operationally relevant with the capabilities of GIS results in a solution that will allow DoD personnel to uniformly populate,
visualize, and share near real-time cultural data relevant to military operations across all services and agencies. This DoD
enterprise solution has the potential to enhance the Nation’s armed forces’ strategic performance through the application of
culturally adept military powe
Sociocultural-Geospatial Anthropological Portal (SC-GAP): enhancing sociocultural understanding through crowdsourced service member narratives
No full textDespite the Department of Defense’s (DOD) investment in programs designed to advance sociocultural knowledge, the DOD lacks a shared repository through which all entities can aggregate, visualize, and share sociocultural data across the enterprise. A gap analysis of DOD’s desired and actual ability to achieve a sociocultural understanding reveals three shortcomings: data, repository, and collaboration. Therefore, we created a proof of concept that bridges the sociocultural gap by harnessing the overlooked potential of deployed service members and their cross-cultural experiences. Service member observations form an untapped resource of sociocultural data; this existing wellspring of sociocultural information needs to be collected and indexed using a common framework. Residing in a geodatabase and interfaced via a crowdsourced Geographic Information System (GIS), this framework aggregates the collected data of service member narratives for the greater Joint Force, thereby creating a dynamic and collaborative living repository. Combining an anthropologically sound and operationally relevant framework with the capabilities of GIS results in a solution that will allow DOD personnel to populate, visualize, and share near-real-time cultural data relevant to military operations across all services. This DOD enterprise solution can enhance the nation’s armed forces’ strategic performance through the application of culturally adept military power.Approved for public release; distribution is unlimited.Sergeant First Class, United States ArmyMajor, United States Armyhttp://archive.org/details/socioculturalgeo109454580
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