84 research outputs found
Velké Popovice: great century in the history of the small village
No full textIn diploma thesis author focuses on history of a village called Velké Popovice. She deals with its history from the end of the 19th century when František Ringhoffer became the owner of the village till the events that followed right after the "Velvet Revolution". The main part of this work is focused on political, agricultural and communal matters of the village. The author deals with Ringhoffer's family and the things that the family managed to realize right in Velké Popovice and in its surroundings. The author deals with Word War I, that violated not only the inhabitants of the village but also soldiers whose fates are shown on life of Josef Kabeláč, a legionary, who came from the village. In other part of the work, the author deals with the important period of the "First Republic" followed by the protectorate at the end of which a big tragedy was about to happen. The following part of the work is focused on the period of communist regime that brought decline in many spheres, its decay and following prosperity in those spheres. The history of the village is extended by detached chapters about Church of Panna Marie Sněžná, brewery of Velké Popovice, education and local club activities
THE IMPACT OF MICA POLYMORPHISMS ON OUTCOME OF UNRELATED HEMATOPOIETIC STEM CELL TRANSPLANTATION
No full textAzacitidine-Containing Induction Regimens Followed by Azacitidine Maintenance Therapy in High Risk Acute Myeloid Leukemia: First Results of the Randomized Phase-II AMLSG 12-09 Study (ClinicalTrials.gov No. NCT01180322)
No full textIMPACT OF THE COMPOSITION OF SALVAGE REGIMENS ON RESPONSE AND OVERALL SURVIVAL IN PRIMARY REFRACTORY ACUTE MYELOID LEUKEMIA
No full textAzacitidine-Containing Induction Regimens Followed by Azacitidine Maintenance Therapy in High Risk Acute Myeloid Leukemia: First Results of the Randomized Phase-II AMLSG 12-09 Study (ClinicalTrials.gov No. NCT01180322)
No full textMatching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation
No full textMajor histocompatibility complex class I polypeptide-related sequence A (MICA) is a highly polymorphic ligand of the activating NKG2D receptor on natural killer (NK) cells, gamma delta-T cells, and NKT cells. MICA incompatibilities have been associated with an increased graft-versus-host disease (GVHD) incidence, and the MICA-129 (met/val) dimorphism has been shown to influence NKG2D signaling in unrelated hematopoietic stem cell transplantation (uHSCT). We investigated the effect of MICA matching on survival after uHSCT. We sequenced 2172 patients and their respective donors for MICA. All patients and donors were high-resolution HLA-typed and matched for 10/10 (n = 1379), 9/10 (n = 636), or 8/10 (n = 157) HLA alleles. Within each HLA match group, cases matched and mismatched for MICA and MICA-129 were analyzed for the end points overall survival (OS), disease-free survival (DFS), nonrelapse mortality (NRM), relapse-incidence (RI), and GVHD. Mismatches at the MICA locus as well as MICA-129 increased with the number of HLA mismatches (MICA mismatched 10/10, 9.2% [n = 127]; 9/10, 22.3% [n = 142]; 8/10, 38.2% [n = 60]; MICA-129 mismatched 10/10, 3.9% [n = 54]; 9/10, 10.2% [n = 65]; 8/10, 17.2% [n = 27]). Adverse OS was observed in the 10/10 match group if MICA-129 was mismatched (10/10, hazard ratio [HR], 1.77; confidence interval [CI], 1.22-2.57; P = .003). MICA-129 mismatches correlated with a significantly worse outcome for DFS in the 10/10 HLA match group (HR, 1.77; CI, 1.26-2.50; P = .001). Higher rates of aGVHD were seen in MICA-129 mismatched cases. Our results indicate that MICA-129 matching is relevant in uHSCT. Prospective typing of patients and donors in unrelated donor search may identify mismatches for MICA-129, and compatible donor selection may improve outcome for this small but high-risk subgroup
ACUTE MYELOID LEUKEMIA WITH RUNX1 MUTATIONS CONSTITUTE A DISTINCT ENTITY ASSOCIATED WITH CHARACTERISTIC CLINICAL AND GENETIC FEATURES AND POOR OUTCOME. A STUDY OF THE AML STUDY GROUP (AMLSG)
No full textMonitoring of FLT3 Phosphorylation and FLT3 Ligand Levels in Patients with FLT3-ITD Mutated Acute Myeloid Leukemia (AML) Treated with Midostaurin within the AMLSG 16-10 Trial of the German-Austrian Study Group
No full textClinical impact of GATA2 mutations in acute myeloid leukemia patients harboring CEBPA mutations: a study of the AML study group
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