139 research outputs found
A general overview of Prader-Willi syndrome
No full textDelia Pogson outlines the pathogenesis of this rare disorder and discusses the multidisciplinary approach required to manage and treat this genetic condition
Prader–Willi syndrome: genotype, cause, phenotype and management
No full textPrader–Willi syndrome (PWS) is a complex neurodevelopmental genetic condition that results in a range of phenotypic features including hypotonia, hyperphagia and behavioural difficulties. PWS is caused by the paternal loss of imprinting genes from the chromosome 15q11.2–13. If left unmanaged, the central obesity caused by hyperphagia and the behavioural features such as foraging and stealing of foods will dominate the life of the person with PWS and his/her family, resulting in practical and psychological difficulties. In this article, Delia Pogson outlines the pathogenesis of this rare disorder and discusses the multidisciplinary approach required to manage and treat this condition
Who is responsible for quality improvement?
No full textAt the 5th European forum on quality improvements in health care it was postulated that the role of total quality management was primarily to protect the patient from harm (Bisognano, 2000). The quality of health care, however, is only as good as the nurse, doctor or therapist who delivers it
Spaces of sensation: The immersive installation and corporal literacy
No full textThis paper investigates the primacy of the corporal in understanding immersive environments. Writing from the perspective of an installation artist who takes this conceit as one of the founding principles of her work, which is predicated on developing immersive installations that are designed to be understood primarily through the somatic perceptual systems (e.g. www.sensedigital.co.uk/SG1.htm). the aim of the paper is to explore the notion that such installations can serve to enhance, or heighten corporal literacy. The installation iSensuous Geographies, created with Alistair MacDonald in 2003, is used to exemplify this practice. In this paper the terms ‘literacy’ and ‘literate’ are used in an extended sense, frequently transposing their original meanings (which pertain to the written word) into meanings which refer to those understandings we glean through our senses. Just as in the visual arts the term visually literate is used to refer to the ability to make fine discriminations in the detail, texture and structures of visual phenomena, and in music the term aurally literate refers to a highly refined ability to identify the detail, texture and structure of sound, the term corporal literacy is used to refer to the ability to discriminate equally subtle details of the structurings and textures of corporal sensation that emanate from the somatic perceptual system during interaction with the environment
Simulation of Invertebrate Aggregation Shows the Importance of Stable Personality over Diversity in Consensus Decision-Making.
No full textAggregation of many species of invertebrate is an example of a consensus decision, the success of which is central to survival. Personality is a stable form of behavioural diversity which has been observed in the aggregation process, but neither the reasons for its stability nor its effects on consensus decisions are well understood. By using an agent-based model of invertebrate aggregation, it is found that diverse personalities have only limited benefits to the experimental consensus decision-making process, but may have a more valuable role in natural settings. Importantly, although certain personalities may ostensibly have potential drawbacks at the individual level, such as choosing to rest in unfavourable places, all individuals are likely to benefit from maintaining a constant personality, which promotes group stability. These findings help to improve understanding of consensus decision-making and the prevalence of stable personality
The Scientific romances of Charles Howard Hinton : the fourth dimension as hyperspace, hyperrealism and protomodernism
No full textThis thesis examines the epistemological, socio-cultural and aesthetic impact of the hyperspace philosophy of Charles Howard Hinton, as expressed within his two-volume
collection of Scientific Romances (1884-1896). Hinton's hyperspace philosophy is founded on the belief that the fourth dimension exists as a transcendental yet material
space that is accessible to both the mind and the physical senses. Inspired by Immanuel Kant's discussion of space as an a priori intuition, Hinton's project is one of
consciousness expansion: he argues that 'a new era of thought' can be attained through the recognition of the fourth dimension. The thesis demonstrates that, in the Scientific Romances, Hinton seeks to engender the 'reality' of the fourth dimension within the reader's imagination through the collaboration of reader and author. Hinton's hyperspace philosophy is thus concerned with mediation, the ways in which the consciousness thinks and creates with and through the aesthetics of space. In addition to providing the most developed analysis of Hinton's writing to date, this thesis examines the work of Hinton's contemporaries
exploring the ways in which the discourse of the fourth dimension can offer new readings of familiar literary texts. A recurring explanatory device throughout
hyperspace philosophy is the dimensional analogy, and the thesis illustrates how this trope resonates across the work of contemporary writers including Lewis Carroll, H. G. Wells, HenryJames, Friedrich Nietzsche and William James
Identity, continuity and consciousness
No full textIt is my intention in this thesis to demonstrate that there exists a clear and explicit formal relationship between the seemingly exclusive descriptions of spatio-temporal and purely temporal continuity, and further, that this relationship manifests itself within our most fundamental understanding of the physical world itself, namely; within our understanding of the identity, diversity and re-identification of material bodies (Book 1). It may therefore be claimed that behind that cultural understanding which leads us to imagine that the physical world is located in both space and time, whereas our thoughts and feelings are located in time alone, there lies a formal logical framework, or an explicit formal description of how being in space and time relates to being in time alone - leading us to wonder, perhaps, whether these two things are really as distinct as we might at first imagine.
That I should then go on (albeit without a formal methodology) to apply to this analysis a philosophical interpretation of Bergson's conception of the relationship between the intuition and the intellect (Book 2) is of lesser importance - indicating as it does little more than my own philosophical inclinations. However, something will be gained, I hope, from this further exercise. Along the way it will allow me to clarify a number of technical points of which the general philosopher may be unaware; for example the unobservable nature of numerical identity and re-identification, the importance of the principle of special relativity to the topic of mind and the technical difficulties of claiming that mental events are 'in time' at all.
Notwithstanding these latter points, however, the intentions of this work are predominantly analytical and are adequately described as an attempt to consolidate spatio-temporal and purely temporal description under a unified logical framework
The Tumbarumba Basaltic Gem Field, New South Wales: in relation to sapphire-ruby deposits of eastern Australia
No full textSutherland, F. L., Graham, I. T., Pogson, R. E., Schwarz, D., Webb, G. B., Coenraads, Robert R., Fanning, C. M., Hollis, J. D., Allen, T. C. (2002): The Tumbarumba Basaltic Gem Field, New South Wales: In Relation to Sapphire-Ruby Deposits of Eastern Australia. Records of the Australian Museum 54 (2): 215-248, DOI: 10.3853/j.0067-1975.54.2002.1358, URL: https://journals.australian.museum/sutherland-et-al-2002-rec-aust-mus-542-215248
Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise.
No full textIt is generally accepted that muscle adaptation to resistance exercise (REX) training is underpinned by contraction-induced, increased rates of protein synthesis and dietary protein availability. By using dynamic proteome profiling (DPP), we investigated the contribution of both synthesis and breakdown to changes in abundance on a protein-by-protein basis in human skeletal muscle. Age-matched, overweight males consumed 9 d of a high-fat, low-carbohydrate diet during which time they either undertook 3 sessions of REX or performed no exercise. Precursor enrichment and the rate of incorporation of deuterium oxide into newly synthesized muscle proteins were determined by mass spectrometry. Ninety proteins were included in the DPP, with 28 proteins exhibiting significant responses to REX. The most common pattern of response was an increase in turnover, followed by an increase in abundance with no detectable increase in protein synthesis. Here, we provide novel evidence that demonstrates that the contribution of synthesis and breakdown to changes in protein abundance induced by REX differ on a protein-by-protein basis. We also highlight the importance of the degradation of individual muscle proteins after exercise in human skeletal muscle.-Camera, D. M., Burniston, J. G., Pogson, M. A., Smiles, W. J., Hawley, J. A. Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise
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