293 research outputs found
Johanneſ von Stvͤ- lingen ein B ~ger ze frib ~g - 1284 Oktober 23.
No full textJohannes von Stühlingen, Bürger zu Freiburg i. Br., beurkundet, daß er Konrad dem Ungeheuern, ebenfalls einem Bürger von Freiburg i. Br., mit Einwilligung des Abtes Meinwart und des Konventes von Thennenbach ein näher bezeichnetes Gut bei Denzlingen um 16 Mark Silbers verkauft und den genannten Betrag bereits dafür erhalten hat. Wenn der Verkäufer stirbt, dürfen Abt und Konvent aus dem Gute, bevor es geteilt wird, 16 Mark oder, was sie an deren Stelle dafür namhaft machen, ohne angefochten zu werden, herausnehmen. --{'name': 'BAdW', 'uri': 'badw.png'
Abstract 2684: Multiplex immunofluorescence profiling of tumor infiltrating immune subsets in HNSCC biopsies provides a powerful tool when combined with patient outcome data
No full textAbstract
Head and neck squamous cell carcinoma (HNSCC) is one of the growing number of tumors for which an anti-tumor immune response is implicated to play a role in the course of the disease. Profiling of the tumor microenvironment including specific infiltrating lymphocyte subsets, antigen presenting cells, expression of regulatory molecules on both tumor and immune cells and spatial relationships between cells could lead to predictive signatures for responsiveness to both conventional and immune modulatory therapies. While flow cytometry results in multi-parametric analysis of immune populations within the tumor, their context i.e. the spatial relationship of these cells to tumor and to other immune cells, is lost. In this current study we use Cell IDx’s novel UltraPlex technology, which is based on a simple two-step, autostainer compatible protocol using hapten labeled primary antibody cocktails followed by fluor labeled anti-hapten secondary cocktails to simultaneously detect 4 cellular markers on the same cell in tumor biopsies. Image registration of serial sections increases multiplexing to 12-16 markers. This technology, which allows generation of full immune subset profiling, quantitative marker expression and relative cellular localization, was applied to a HNSCC tumor microarray as a test system. Data are presented showing the potential of this technology for correlation of tumor “immune signature” with patient outcome.
Citation Format: Matt Levin, Mark Lingen, David Schwartz, Helen Snyder. Multiplex immunofluorescence profiling of tumor infiltrating immune subsets in HNSCC biopsies provides a powerful tool when combined with patient outcome data [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2684. doi:10.1158/1538-7445.AM2017-2684</jats:p
GDF-15, MRproADM, CTproET1 and CTproAVP in Patients with asymptomatic diastolic Dysfunction
No full text
6. Oktober 1916
No full textStadtarchiv Solingen, Bergische Arbeiterstimme 6. Oktober 1916 Die Bilanz der 5. Kriegsanleihe für „Solingen und Umgegend“ Die Solinger Zeichnungen auf die Kriegsanleihe Auf die fünfte Kriegsanleihe wurden in So- lingen und Umgegend (mit Ausnahme von Ohligs) unter Einbeziehung der Sparkassen-Zeichnungen insge- samt gezeichnet 16½ Millionen Mark. Bei der Solinger Reichsbankstelle wurden 1 700 000 Mark gezeichnet und 7½ Millionen gezahlt. Die überschießen..
Design of an object oriented Finite Element package for parallel computers
No full textAerospace Engineerin
Observations on the biology and seasonal variation in feeding of the East Coast redeye round herring (Etrumeus wongratanai) (Clupeiformes), off Scottburgh, KwaZulu-Natal, South Africa
No full textMagister Scientiae (Biodiversity and Conservation Biology) - MSc (Biodiv and Cons Biol)The basic biology and ecology of Etrumeus wongratanai was investigated from samples of fish collected by jigging off Scottburgh, Kwazulu-Natal throughout 2014 and 2015. A total of 516 otoliths, 401 gonads, 140 stomachs and 163 samples of white muscle tissue was examined, and length and weight data of 3 637 fish caught between 2013 and 2016 was also analysed. Counts of annuli deposited on sagittal otoliths indicate that sampled E. wongratanai ranged from 0 to 3 y. (year/s) of age. Length-at-age for males (females) was estimated at 15.5 cm (16.2 cm) for 1 y. olds, 17.7 cm (17.4 cm) for 2 y. olds and 19.6 cm (18.8 cm) for 3 y. olds. The length at 50% maturity was estimated to be 15.6 cm for males, and 16.1 cm for females. Etrumeus wongratanai showed high gonadosomatic index values from June to December indicating that the breeding season lasts for 6 and 8 months for males and females, respectively, and that spawning takes place from the onset of winter to early summer. Condition factor was lowest in May through to August and increased from September. The low condition factor values from May through to
August could be due to the physiological strain before and during the spawning season. Fish larvae were the most important food item in samples collected in summer, whereas eucalanids were the most important prey item in autumn and winter. Overall, large copepods were the dominant prey items in terms of frequency and importance. Stable isotope data suggests that there are gradual changes in the trophic level and diet of E. wongratanai as it increases with size, and whilst δ¹⁵N values differed between seasons δ¹³C did not. The results obtained here are
compared with other species of Etrumeus, regionally and globally.National Research Foundation (NRF) and ACEP Phulis
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Kesselring's last battle ::war crimes trials and Cold War politics, 1945-1960 /
No full textIn 1947 German Field Marshal Albert Kesselring was tried and convicted of war crimes committed during World War II. He was held responsible for his troops having executed nearly 9,000 Italian citizens-- women, children, elderly men-- in retaliation for partisan attacks. His conviction, however, created a real dilemma for the United States and western Europe. While some sought the harshest punishments available for anyone who had participated in the war crimes of the Nazi regime, others believed that the repatriation of alleged war criminals would help secure the allegiance of a rearmed West Germany in the dangerous new Cold War against the Soviet Union. This close analysis of the Kesselring case reveals for the first time how a network of veterans, lawyers, and German sympathizers in Britain and America achieved the commutation of Kesselring's death sentence and his eventual release-- reinforcing German popular conceptions that he had been innocent all along and that the Wehrmacht had fought a "clean war" in Italy. But the author shows that Kesselring bore much greater guilt for civilian deaths than had been proven in court-- and that the war on the Southern Front had been far from clean. In this narrative, she shows how international politics shaped the trial's proceedings and outcome-- as well as the memory and meaning of the war for German citizens-- and sheds new light on the complex interplay between the combatants' efforts to "master the past" and the threatening state of international relations in the early Cold War. In analyzing the efforts to clear Kesselring's name, von Lingen shows that the case was about much more than the fate of one convicted individual; it also underscored the pressure to wrap up the war crimes issue-- and German guilt-- in order to get on with the business of bringing a rearmed Germany into the Western alliance. It sheds new light on the "politics of memory" by unraveling a twisted thread in postwar history as it shows how historical truth is sometimes sacrificed on the altar of expediency
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