5 research outputs found
Lessons from the Hvidoere International Study Group on childhood diabetes: be dogmatic about outcome and flexible in approach
No full textSCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe
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Risk factors associated with the exposure of neonates to acinetobacters through the ingestion of infant formula in NICUs
No full textAcinetobacter is gaining importance as a pathogen in intensive care units (ICUs) due to the numerous outbreaks reported and the severity of the infections caused. Of particular interest in this project are neonates whose immune systems have not fully developed and affected by their prematurity, low birth weight, or various other conditions. The vulnerability of these neonates combined with the multidrug resistance of the clinical isolates of this organism poses a real threat to neonates. The understanding of its pathogenicity is still at an elementary stage despite the clinical evidence of nosocomial infections, and the concern of the FAOWHO (2006) regarding neonatal health due to the consumption of powdered infant formula (PIF). The ingestion of contaminated infant formula is a particularly unexplored mechanism of acquiring Acinetobacter infections. Therefore, this research work aimed to analyse the potential risk factors associated with the consumption of a contaminated infant formula administered enterally
Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome
No full textIncludes bibliography.Despite major advances over the last two decades with the management of patients with Zollinger-Ellison syndrome (ZES), unanswered questions remain concerning the natural history of the disease, the impact of new diagnostics modalities on cure rates, and the role of surgery in the era of modem medical therapies. The aims of the thesis are to (i) analyse the database of 40 ZES patients treated at Groote Schuur Hospital (GSH) over two decades, with special reference to the impact of various surgical strategies on outcome, (ii) investigate a possible correlation between biological tissue marker expression and tumour behaviour, (iii) study the effect of somatostatin receptor scintigraphy (SRS) on surgical cure rates, and (iv) assess the efficacy and safety of a new proton pump inhibitor (pantoprazole) in controlling acid hypersecretion
