441 research outputs found
Activation of mGluR5 Induces Rapid and Long-Lasting Protein Kinase D Phosphorylation in Hippocampal Neurons
No full textMetabotropic glutamate receptors (mGluRs), including mGluR5, play a central role in regulating the strength and plasticity of synaptic connections in the brain. However, the signaling pathways that connect mGluRs to their downstream effectors are not yet fully understood. Here, we report that stimulation of mGluR5 in hippocampal cultures and slices results in phosphorylation of protein kinase D (PKD) at the autophosphorylation site Ser-916. This phosphorylation event occurs within 30 s of stimulation, persists for at least 24 h, and is dependent on activation of phospholipase C and protein kinase C. Our data suggest that activation of PKD may represent a novel signaling pathway linking mGluR5 to its downstream targets. These findings have important implications for the study of the molecular mechanisms underlying mGluR-dependent synaptic plasticity.Howard Hughes Medical InstituteFRAXA Research FoundationNational Institute of Mental Health (U.S.)Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.
Alive but Cancelled: The Public’s Response to the Controversial Author
No full textThis thesis explores how the public has responded to authors J.K. Rowling and Lionel Shriver, who have become the subject of public controversy, and what this response tells us about the current conceptions about the author. Academics like Wenche Ommundsen and English & Frow have established that authors are no longer the faceless names they once were, and several of them have reached a proper celebrity status. Especially now, in a time in which social media exerts great influence on how the general public views celebrities and concepts like “wokeness” and social justice become increasingly relevant topics, celebrities and celebrity authors are often expected to display socially just behaviour and reprimanded when they do not. By analysing the online responses to the controversies caused by these two prominent authors, this thesis argues that the public perceives a strong relationship between authors and their work and generally attributes a great deal of responsibility to popular authors with vast platforms.
Keywords: Lionel Shriver; J.K. Rowling; literary celebrity; wokeness; cancel culture; Death of the Author; transphobia; cultural appropriatio
OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and Europeans
No full textContemporary variation in skin pigmentation is the result of hundreds of thousands years of human evolution in new and changing environments. Previous studies have identified several genes involved in skin pigmentation differences among African, Asian, and European populations. However, none have examined skin pigmentation variation among Indigenous American populations, creating a critical gap in our understanding of skin pigmentation variation. This study investigates signatures of selection at 76 pigmentation candidate genes that may contribute to skin pigmentation differences between Indigenous Americans and Europeans. Analysis was performed on two samples of Indigenous Americans genotyped on genome-wide SNP arrays. Using four tests for natural selection-locus-specific branch length (LSBL), ratio of heterozygosities (lnRH), Tajima's D difference, and extended haplotype homozygosity (EHH)-we identified 14 selection-nominated candidate genes (SNCGs). SNPs in each of the SNCGs were tested for association with skin pigmentation in 515 admixed Indigenous American and European individuals from regions of the Americas with high ground-level ultraviolet radiation. In addition to SLC24A5 and SLC45A2, genes previously associated with European/non-European differences in skin pigmentation, OPRM1 and EGFR were associated with variation in skin pigmentation in New World populations for the first time.Fil: Quillen, Ellen E.. State University of Pennsylvania; Estados Unidos. Texas Biomedical Research Institute; Estados UnidosFil: Bauchet, Marc. Institut Max Planck for Evolutionary Anthropology; AlemaniaFil: Bigham, Abigail W.. University of Michigan; Estados UnidosFil: Delgado Burbano, Miguel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Cienicas Naturales y Museo. División Antropología; ArgentinaFil: Faust, Franz X.. Universidad del Cauca; ColombiaFil: Klimentidis, Yann C.. University of Alabama at Birmingahm; Estados UnidosFil: Mao, Xianyun. State University of Pennsylvania; Estados UnidosFil: Stoneking, Mark. Institut Max Planck for Evolutionary Anthropology; AlemaniaFil: Shriver, Mark D.. State University of Pennsylvania; Estados Unido
Forensic DNA Analysis: From Modest Beginnings to Molecular Photofitting, Genics, Genetics, Genomics, and the Pertinent Population Genetics Principles
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Applied behavior analysis in education: The role of the Board Certified Behavior Analyst.
No full textThe cave: A search for the mother’s story in narrative literature
No full textThe mother’s voice is underrepresented in literature. The mother has been a silent figure, always present, often near, featuring in the story of another, but rarely the focus of the story. She has been spoken for, about and around, but rarely empowered to speak for herself.
In this thesis I argue that the mother’s story, in narrative fiction and memoir, should be available, and culturally valued. Since the diversity of women’s experiences of mothering cannot be explained by any single theory or ideology, narrative may articulate the complexities and ambiguities experienced in motherhood in ways that scholarly discourses do not always allow.
This thesis includes a creative component—a collection of related fictional stories narrated by one mother, and entitled “The Cave”. Adopting the concept of the cave, as a metaphor for the transformative potential of mothering, the fiction draws on the mundane, everyday experiences of a life that is centred on caring for children. The exegesis that follows is based on three approaches to mothering narratives: their research, reading and writing. It explores the emergence of the mother’s story within theoretical discourses around motherhood, and its more recent appearances in fiction and non-fiction narratives. It suggests reasons for the absence of the mother’s subjective voice, argues that women have been disadvantaged by this silence, and seeks new possibilities for representing the complexity of mothering experiences
Conductivity anisotropy of polyphosphazene-montmorillonite composite electrolytes
No full textThe conductivity of an ordered polyphosphazene Na+-montmorillonite composite has been measured perpendicular (sigma(para)) and parallel (sigma(perp)) to the montmorillonite layers, and the sigma(para)/sigma(perp) is about 100. The temperature dependence of the conductivity is consistent with a coupling between long-range Na+ movement and high-amplitude segmental motion of the polymer. The anisotropy is attributed to greater tortuosity of the Na+ diffusion perpendicular to the montmorillonite layers.Source type: Electronic(1
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