140 research outputs found
Henri Temianka Correspondence; (cadogan)
No full textThis collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/1524/thumbnail.jp
comments on Cadogan and Lee
No full textHenseler, J., & Schuberth, F. (2023). Partial least squares as a tool for scientific inquiry: comments on Cadogan and Lee. European Journal Of Marketing, 57(6), 1737-1757. https://doi.org/10.1108/EJM-06-2021-0416 --- %ABS3% ---Funding Information: Additionally, the first author gratefully acknowledges financial support from FCT Fundação para a Ciência e a Tecnologia (Portugal), national funding through a research grant from the Information Management Research Center – MagIC/NOVA IMS (UIDB/04152/2020). The first author also acknowledges a financial interest in the composite-based SEM software ADANCO and its distributor, Composite Modeling.Abstract Purpose In their paper titled “A Miracle of Measurement or Accidental Constructivism? How PLS Subverts the Realist Search for Truth,” Cadogan and Lee (2022) cast serious doubt on PLS’s suitability for scientific studies. The purpose of this commentary is to discuss the claims of Cadogan and Lee, correct some inaccuracies, and derive recommendations for researchers using structural equation models. Design/methodology/approach This paper uses scenario analysis to show which estimators are appropriate for reflective measurement models and composite models, and formulates the statistical model that underlies PLS Mode A. It also contrasts two different perspectives: PLS as an estimator for structural equation models vs. PLS-SEM as an overarching framework with a sui generis logic. Findings There are different variants of PLS, which include PLS, consistent PLS, PLSe1, PLSe2, proposed ordinal PLS and robust PLS, each of which serves a particular purpose. All of these are appropriate for scientific inquiry if applied properly. It is not PLS that subverts the realist search for truth, but some proponents of a framework called “PLS-SEM.” These proponents redefine the term “reflective measurement,” argue against the assessment of model fit and suggest that researchers could obtain “confirmation” for their model. Research limitations/implications Researchers should be more conscious, open and respectful regarding different research paradigms. Practical implications Researchers should select a statistical model that adequately represents their theory, not necessarily a common factor model, and formulate their model explicitly. Particularly for instrumentalists, pragmatists and constructivists, the composite model appears promising. Researchers should be concerned about their estimator’s properties, not about whether it is called “PLS.” Further, researchers should critically evaluate their model, not seek confirmation or blindly believe in its value. Originality/value This paper critically appraises Cadogan and Lee (2022) and reminds researchers who wish to use structural equation modeling, particularly PLS, for their statistical analysis, of some important scientific principles.publishersversionpublishe
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Accessing Multiple Classes of 2H‑Indazoles: Mechanistic Implications for the Cadogan and Davis–Beirut Reactions
No full textThe Cadogan cyclization is a robust but harsh method for the synthesis of 2 H-indazoles, a valuable class of nitrogen heterocycles. Although nitrene generation by exhaustive deoxygenation is widely accepted as the operating mechanism in the reductive cyclization of nitroaromatics, non-nitrene pathways have only been theorized previously. Here, 2 H-indazole N-oxides were synthesized through an interrupted Cadogan/Davis-Beirut reaction and are presented as direct evidence of competent oxygenated intermediates; mechanistic implications for both reactions are discussed. Isolation and characterization of these N-oxides enabled a formal Cadogan cyclization at room temperature for 2 H-indazole synthesis
Cadogan, Marjorie
No full textINTERVIEWER: Mark Naison
INTERVIEWEE: Marjorie Cadogan
SUMMARY BY: Patrick O’Donnell
Marjorie Cadogan (b. 1960) is a graduate of Fordham University and Fordham University Law, and she is an Executive Deputy Commissioner of the Human Resources Administration in New York. She is the daughter of Bajan immigrants. Her father immigrated twice (in the ‘40’s and then the mid ‘50’s), and her mother came to the US in the late ‘50’s. While her mother and father knew each other in Barbados, they did not get married until 1959, when they both lived in the US. Her mother was a licensed nurse in Barbados, and she worked as a private nurse when she moved to New York. Marjorie’s father, a mechanic by trade, had a 7th grade education and worked several jobs to support his family. The couple raised Marjorie, an only child, on 218th St., between Bronxwood and Pauling Avenues. The block was very multiracial: there were a few black families and a high percentage of Latinos.
Despite the fact that Mr. Cadogan was not formally educated, he valued education a great deal, and he was a lifelong learner, jazz aficionado, and great conversationalist. Marjorie describes him as a “practical intellectual.” Marjorie recalls being steeped in Bajan music, food, and culture growing up, even while she enjoyed the cultural resources of the Bronx and the other ethnicities that inhabited it. She also learned piano as a child. Marjorie’s parents had a mixed religious background, but did not identify with one church in particular. However, because they did not want Marjorie to attend public high school (they were zoned for Evander, which had a rough reputation), they placed her in Our Lady Grace elementary. Marjorie was a good student, obedient, an early reader, and a fast learner, and she enjoyed school both at Our Lady Grace and at her High School, St. Catherine’s.
After high school, Marjorie wanted to attend either Fordham or Harvard. However, her counselor discouraged her from applying to Harvard because of her race. Nevertheless, she did not make the decision to forgo attending Harvard until she had a negative interview experience with a Harvard alumna, who, upon their meeting, expressed disappointment on learning that she was black and not Irish. Thus she attended Fordham, majoring in Spanish and English. She achieved fluency in Spanish and spent a year in Spain. In the interview, she recalls several members of the faculty who were particularly inspirational for her. Subsequently, she attended Fordham Law at Lincoln Center, where she was one of three students of color in a 300 person class. While she was a solid law student, her grades were not promising enough for her to practice at a high level. She considered a career as a criminal lawyer, but then decided that she would get stuck in the occupation. As a result, she began to focus on public service, eventually landing a job at the New York City Law Department. While she works in Manhattan, Cadogan has deep Bronx roots, and she does not see anything that Manhattan offers that the Bronx does not have. In particular, she values the sense of community and the residential neighborhoods that the Bronx offers
Accessing Multiple Classes of 2<i>H</i>‑Indazoles: Mechanistic Implications for the Cadogan and Davis–Beirut Reactions
No full textThe
Cadogan cyclization is a robust but harsh method for the synthesis
of 2H-indazoles, a valuable class of nitrogen heterocycles.
Although nitrene generation by exhaustive deoxygenation is widely
accepted as the operating mechanism in the reductive cyclization of
nitroaromatics, non-nitrene pathways have only been theorized previously.
Here, 2H-indazole N-oxides were
synthesized through an interrupted Cadogan/Davis–Beirut reaction
and are presented as direct evidence of competent oxygenated intermediates;
mechanistic implications for both reactions are discussed. Isolation
and characterization of these N-oxides enabled a
formal Cadogan cyclization at room temperature for 2H-indazole synthesis
Accessing Multiple Classes of 2<i>H</i>‑Indazoles: Mechanistic Implications for the Cadogan and Davis–Beirut Reactions
No full textThe
Cadogan cyclization is a robust but harsh method for the synthesis
of 2H-indazoles, a valuable class of nitrogen heterocycles.
Although nitrene generation by exhaustive deoxygenation is widely
accepted as the operating mechanism in the reductive cyclization of
nitroaromatics, non-nitrene pathways have only been theorized previously.
Here, 2H-indazole N-oxides were
synthesized through an interrupted Cadogan/Davis–Beirut reaction
and are presented as direct evidence of competent oxygenated intermediates;
mechanistic implications for both reactions are discussed. Isolation
and characterization of these N-oxides enabled a
formal Cadogan cyclization at room temperature for 2H-indazole synthesis
Accessing Multiple Classes of 2<i>H</i>‑Indazoles: Mechanistic Implications for the Cadogan and Davis–Beirut Reactions
No full textThe
Cadogan cyclization is a robust but harsh method for the synthesis
of 2H-indazoles, a valuable class of nitrogen heterocycles.
Although nitrene generation by exhaustive deoxygenation is widely
accepted as the operating mechanism in the reductive cyclization of
nitroaromatics, non-nitrene pathways have only been theorized previously.
Here, 2H-indazole N-oxides were
synthesized through an interrupted Cadogan/Davis–Beirut reaction
and are presented as direct evidence of competent oxygenated intermediates;
mechanistic implications for both reactions are discussed. Isolation
and characterization of these N-oxides enabled a
formal Cadogan cyclization at room temperature for 2H-indazole synthesis
Accessing Multiple Classes of 2<i>H</i>‑Indazoles: Mechanistic Implications for the Cadogan and Davis–Beirut Reactions
No full textThe
Cadogan cyclization is a robust but harsh method for the synthesis
of 2H-indazoles, a valuable class of nitrogen heterocycles.
Although nitrene generation by exhaustive deoxygenation is widely
accepted as the operating mechanism in the reductive cyclization of
nitroaromatics, non-nitrene pathways have only been theorized previously.
Here, 2H-indazole N-oxides were
synthesized through an interrupted Cadogan/Davis–Beirut reaction
and are presented as direct evidence of competent oxygenated intermediates;
mechanistic implications for both reactions are discussed. Isolation
and characterization of these N-oxides enabled a
formal Cadogan cyclization at room temperature for 2H-indazole synthesis
Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease
No full textSynaptic and dendritic pathology is a well-documented component of prion disease. In common with other neurodegenerative diseases that contain an element of protein misfolding, little is known about the underlying mechanisms of synaptic degeneration. In particular, in prion disease the relationship between synaptic malfunction, degeneration, and mitochondria has been neglected. We investigated a wide range of mitochondrial parameters, including changes in mitochondrial density, inner membrane ultrastructure, functional properties and nature of mitochondrial DNA from hippocampal tissue of mice with prion disease, which have ongoing synaptic pathology. Our results indicate that despite a lack of detectable changes in either mitochondrial density or expression of the mitochondrial proteins, mitochondrial function was impaired when compared with age-matched control animals. We observed changes in mitochondrial inner membrane morphology and a reduction in the cytochrome c oxidase activity relative to a sustained level of mitochondrial proteins such as porin and individual, functionally important subunits of complex II and complex IV. These data support the idea that mitochondrial dysfunction appears to occur due to inhibition or modification of respiratory complex rather than deletions of mitochondrial DNA. Indeed, these changes were seen in the stratum radiatum where synaptic pathology is readily detected, indicating that mitochondrial function is impaired and could potentially contribute to or even initiate the synaptic pathology in prion disease
A search for field-induced ordering in the optimally doped Ba(Fe, Co)(2)As-2 superconductor
No full textA Fe-57 Mossbauer search for field-induced magnetic order in optimally doped Ba(Fe1-xCox)(2)As-2 in fields of up to 6 T showed no changes that could be attributed to field-induced order. We also observed no difference between the normal (30 K) and superconducting states (5 K). Any field-induced order is certainly less than 1% of the order present in the parent BaFe2As2.This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Quinn, Katherine, D. H. Ryan, P. C. Canfield, S. L. Bud'ko, and J. M. Cadogan. "A search for field-induced ordering in the optimally doped Ba (Fe, Co) 2 As 2 superconductor." Journal of Applied Physics 113, no. 17 (2013): 17E127, and may be found at DOI: 10.1063/1.4795421. Posted with permission.</p
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