1,721,075 research outputs found
Espressione immunoistochimica dell"endotelina-1 nei tumori mammari del cane e suo ruolo nell"angiogenesi neoplastica
No full textServizio di diagnostica istopatologica: risultati del quinquennio 2003-2008 con particolare riferimento ai tumori mammari del cane e del gatto
No full textImmunohistochemical detection of cyclin E, cyclin D1 and Ki-67 in mammary tumors in the cat.
No full textIndagini preliminari sull’espressione immunoistochimica della proteina p53 nel seminoma del cane
Full text linkSUMMARY - Tlie p53 protein is a transcription factor inducing celi cycle arresi and apoptosis
against a DNA damage. p53 mutations might lead to lose its inibitoring growth functions and
contribute to not controlied cellular proliferation. Mutations and/or overexpression of p53 are
thè most comnion genetic alterations found in human cancer. The role of thè p53 protein in
cancerogenesis m domestic animals is stili largely unknown. This prelimmary study
investigates thè expression of p?3 in 16 semmomas of thè dog using a standard streptavidinbiotin
peroxidase method after microwave antigen retrieval. In 9 diffuse seminomas tlie
mtensity of p53 expression is of low degree (^), in 5 diffuse seminomas is of middle degree
(++) and m 2 intratubular seminomas is of higt degree (+++). The results suggest tlie p53
expression m seminoma of thè dog decreases with advancing stage of neoplastic process
Prognostic value of cyclin D1, p27 and Ki-67 in mammary tumours in the dog: an immunohistochemical approach
No full textImmunohistochemical expression of endothelin-1, VEGF and VEGF-R1 in mammary tumours in the dog and their role in neoplastic angiogenesis.
No full text
Immunohistochemical evaluation of ovarian hormonal receptors in canine mammary tumors
Full text linkBackground: In female dogs, ovarian hormones have a crucial role in the pathogenesis of mammary tumors. Ovarian hormones interact with nuclear receptors, estrogen receptor α (ERα) and β (ERβ), progesteron receptor (PR) and andro- gen receptor (AR) respectively. The aim of this study was to verify the existence of correlations between biological be- haviour and immunohistochemical expression of estrogen receptor α (ERα) and β (ERβ), progesterone receptor (PR) and androgen receptor (AR) in canine mammary tumors. A total of sixty-four tumors were examined. Results: The ex- pression of every receptor was higher in normal tissue and benign tumors than in malignant neoplasm. Among malig- nancies, the lowest levels of every receptor were detected in high grade carcinomas (p 0.05). Conclusions: The expression of ERα and/or PR showed the positive prognostic value for the Spearman’s rank test (p 0.05). In human breast carcinoma, AR seems to be involved in metastatic development by up-regulation of metallopro- tease of matrix (MMP). Therefore, evaluating the correlation among the presence of AR, expression of MMP and ap- pearance of distant metastasis also in canine mammary tumors could be very interesting
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