550 research outputs found
GEOGRAFIE DEL VINO: COSTRUZIONE STORICA E PATRIMONIALIZZAZIONE DEI PAESAGGI VITICOLI
No full textThis research project is supposed to face up viticulture in a complex, epistemological framework. As Dickenson and Salt affirm the geography of the wine «may be studied from a variety of perspectives and encompasses the influence of the physical environment, historical diffusion of the vine and viticulture, economic geographies of cultivation and marketing, political influences on trade and production, and cultural perceptions of landscapes, product and people». After all, already in the Latin etymology of viticulture exists a deep content hiatus that imposes to consider two fair enough different concepts; indeed, culture may refer to cultivation and care. Therefore, it is crucial to understand how viticulture must be considered and to show the way its dichotomic nature may suggest distant methodologies of investigation.
After having underlined the epistemological framework of viticulture in relationship to geography and given the interpretative tools of the research, I analyzed the construction and the evolution of some viticultural landscapes (Montalcino, Barolo, Bolgheri and the Côte d’Or) whose choice depends on the dynamics that regarded their production (characterized by a particular propensity to commercialization), the relationships and the differences among them and finally the essential relationship that wine creates with its territory of origin. The role of the tradition represents the fil rouge that links these experiences and it declines in a different perspective according to the realities I analyzed. However, for each of them, it has been fundamental the role developed by a forerunner; indeed, Ferruccio Biondi for Brunello di Montalcino, Juliette Colbert-Falletti for Barolo and Mario Incisa della Rocchetta for the Sassicaia have not only contributed to the creation of a wine but generally to the development of a whole territory that is identified today in the cultivation of the grapevine.
Finally, in virtue of such a rooted and shared historical construction, these territories take part in the processes of patrimonialization that are characterizing some wine regions to a global scale. Following different criterions of classification, where however viticulture covers a preponderant aspect, Val d’Orcia, Langhes and the climats de Bourgogne are considered from the UNESCO a human world heritage to safeguard while Bolgheri has been inserted by Regione Tuscana in the catalog of the historical rural landscapes; in all these cases, independently from who promoted the patrimonialization, the aim is clear: to allow the future generations to enjoy the cultural and environmental wealth that distinguish them. The wine landscapes are reported to be the ones that underwent fast and important transformations. Moving from this, I underline the debate around the relationship between patrimonialization (considered as a specific process of conservation) and the general transformation of the landscape. From this perspective, the criterions of patrimonialization adopted for the viticultural landscapes seem not to consider the eventuality of one change in the case wine shouldn’t play the social and economic role that it has nowadays. What would it happen in that case
sj-docx-2-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function
No full textSupplemental material, sj-docx-2-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry</p
Pharmacogenetic analysis of serotonin receptors and clinical response to clozapine in schizophrenia patients
No full textgrantor:
University of TorontoClozapine, the prototype of atypical antipsychotic drugs, is the best means available for the treatment of schizophrenia patients refractory or intolerant to typical antipsychotic therapy. Its pharmacological profile is quite unique as it possesses affinity for receptors from many different neurotransmitter systems. The serotonergic system has been implicated in the mechanism of action of clozapine. In particular, clozapine's affinity at 5-HT2A, 5-HT2C, 5-HT1A, 5-HT6, and 5-HT7 receptors may contribute to its many unique clinical attributes. Using a pharmacogenetic approach in 185 schizophrenia patients who have been prospectively assessed for clozapine response, we have examined the hypothesis that polymorphisms in the 5-HT2A (HTR2A), and 5-HT2C (F-HTR2C) genes are involved in its variable response. Polymorphisms in the 5-HT1A (HTR1A), 5-HT6 (HTR6), and 5-HT7 (HTR7) receptor genes were also examined in this sample. The pro16leu HTR1A polymorphism was not observed in our sample; all individuals genotyped were pro/pro 16 homozygotes. Overall, our results are consistent with the hypothesis that genetic variation in the 5-HT2A receptor is involved in the phenotype of clozapine response. (Abstract shortened by UMI.)M.Sc
Coricobasal Syndrome: Clinical, Neuropsychological, Imaging, Genetic and Pathological Features
No full textCorticobasal Syndrome (CBS) is a rare movement and cognitive disorder. There is significant heterogeneity observed in it clinical presentation, neuroimaging, pathology and genetics. Understanding this heterogeneity is a priority and may help to shed light on underlying pathogenic mechanisms. We first demonstrated that truncating mutations in the progranulin gene (PGRN) can cause familial CBS associated with frontotemporal lobar degeneration (FTLD)-ubiquitin pathology. This study identified a mutation in PGRN (Intervening Sequence 7+1 guanine > adenine [IVS7+1G>A]) that segregated with CBS in a family. The mutation was predicted to result in a shortened messenger RNA (mRNA) sequence and the absence of the mutant PGRN allele was confirmed in the reverse transcriptase-polymerase chain reaction (RT-PCR) product, which supported the model of haploinsufficiency for PGRN-linked disease. In a second familial study, clinical, radiological, genetic, and pathological studies were performed to contrast clinical features of the affected members. Sequencing PGRN revealed a novel, heterozygous cytosine-adenine dinucleotide deletion in exon 11 (g.2988_2989delCA, P439_R440fsX6). The proband`s clinical diagnosis was frontotemporal dementia and parkinsonism (FTDP). The proband’s brother with the same mutation presented initially as a progressive non-fluent aphasia (PNFA), and later evolved into a CBS. Pathological analysis revealed Frontotemporal Lobar Degeneration-Ubiquitin (FTLD-U)/ TAR DNA-binding protein 43 (TDP43) positive pathology. The next studies shift away from pathogenic mechanisms to focus on brain-behavioural correlations and phenotypic heterogeneity in a prospective sample of 31 CBS cases. We provide the first direct correlative analysis between the severity of ideomotor apraxia, a common sign in CBS, and cerebral SPECT perfusion imaging. Reductions in perfusion within the left inferior parietal lobule (t=5.7, p=0.03, Family-Wise Error [FWE] corrected), including the left angular gyrus (t=5.7, p=0.02, FWE corrected), were associated with more severe ideomotor apraxia. We stratified the sample into CBS presenting with early motor features (CBS-M; n=9) or early dementia (CBS-D; n=22), which identified that CBS-M were more likely to have cortical sensory loss than CBS-D (p=0.005). In contrast, the presence of aphasia was found to be more common and severe in CBS-D compared to CBS-M (p=0.02). CBS-M patients had significantly reduced perfusion in the right supplementary and premotor areas compared to CBS-D (p<0.05).Ph
Pharmacogenetic analysis of serotonin receptors and clinical response to clozapine in schizophrenia patients
No full textgrantor:
University of TorontoClozapine, the prototype of atypical antipsychotic drugs, is the best means available for the treatment of schizophrenia patients refractory or intolerant to typical antipsychotic therapy. Its pharmacological profile is quite unique as it possesses affinity for receptors from many different neurotransmitter systems. The serotonergic system has been implicated in the mechanism of action of clozapine. In particular, clozapine's affinity at 5-HT2A, 5-HT2C, 5-HT1A, 5-HT6, and 5-HT7 receptors may contribute to its many unique clinical attributes. Using a pharmacogenetic approach in 185 schizophrenia patients who have been prospectively assessed for clozapine response, we have examined the hypothesis that polymorphisms in the 5-HT2A (HTR2A), and 5-HT2C (F-HTR2C) genes are involved in its variable response. Polymorphisms in the 5-HT1A (HTR1A), 5-HT6 (HTR6), and 5-HT7 (HTR7) receptor genes were also examined in this sample. The pro16leu HTR1A polymorphism was not observed in our sample; all individuals genotyped were pro/pro 16 homozygotes. Overall, our results are consistent with the hypothesis that genetic variation in the 5-HT2A receptor is involved in the phenotype of clozapine response. (Abstract shortened by UMI.)M.Sc
sj-pdf-1-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function
No full textSupplemental material, sj-pdf-1-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry</p
sj-docx-3-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function
No full textSupplemental material, sj-docx-3-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry</p
Corrigendum to “Dissemination in time and space in presymptomatic granulin mutation carriers: A spatial chronnectome study” [Neurobiology of Aging Volume 108, December 2021, Pages 155–167]
No full textRefers to
Enrico Premi, Marcello Giunta, Armin Iraji, Srinivas Rachakonda, Vince D. Calhoun, Stefano Gazzina, Alberto Benussi, Roberto Gasparotti, Silvana Archetti, Martina Bocchetta, Dave Cash, Emily Todd, Georgia Peakman, Rhian Convery, John C. van Swieten, Lize Jiskoot, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Chris R. Butler, Isabel Santana, Alexander Gerhard, Isabelle Le Ber, Florence Pasquier, Simon Ducharme, Johannes Levin, Adrian Danek, Sandro Sorbi, Markus Otto, Jonathan D. Rohrer, Barbara Borroni
Dissemination in time and space in presymptomatic granulin mutation carriers: a GENFI spatial chronnectome study. Neurobiology of Aging, Volume 108, December 2021, Pages 155-167 DOI of original article: 10.1016/j.neurobiolaging.2021.09.001.© 2022 Elsevier Inc. The authors regret that the GENFI authors were listed at the end of the article in the Appendix. The GENFI authors are also part of co-authors. The updated author list is below. The authors would like to apologise for any inconvenience caused
Voxel-based Analysis of Cholinesterase Inhibitor Response in Lewy Body Disorders: A Prospective Observational Study
No full textLewy body disorders (LBD) have visual hallucinations, fluctuations in attention and alertness, and parkinsonism as common features. While cholinesterase inhibitors (ChEIs) are an effective treatment for LBD, our understanding of the effects of these drugs in the brain in relation to response is limited. The objective is to investigate functional neuroimaging correlates of response to ChEIs. Standardized neuropsychiatric and neuropsychological batteries and brain perfusion SPECT scans were completed at baseline and after six-months following initiation of ChEIs. This study investigated longitudinal relationships between changes in battery test scores and perfusion using statistical parametric mapping. Treatment with ChEIs resulted in significantly increased occipital perfusion. Significant improvements in working memory, visuospatial performance, and executive functions were observed. Visual hallucinations were significantly reduced, which correlated with increased occipital perfusion. This study identified occipital perfusion as an important correlate of response to ChEIs in LBD, which could be further developed as a response biomarker.M.Sc
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