21 research outputs found
CCDC 1995088: Experimental Crystal Structure Determination
No full textRelated Article: Nittert Marinus, Nabil Tahiri, Margherita Duca, L. M. C. Marc Mouthaan, Simona Bianca, Marco van den Noort, Bert Poolman, Martin D. Witte, Adriaan J. Minnaard|2020|Org.Lett.|22|5622|doi:10.1021/acs.orglett.0c0198
CCDC 1995084: Experimental Crystal Structure Determination
No full textRelated Article: Nittert Marinus, Nabil Tahiri, Margherita Duca, L. M. C. Marc Mouthaan, Simona Bianca, Marco van den Noort, Bert Poolman, Martin D. Witte, Adriaan J. Minnaard|2020|Org.Lett.|22|5622|doi:10.1021/acs.orglett.0c0198
CCDC 1995084: Experimental Crystal Structure Determination
No full textRelated Article: Nittert Marinus, Nabil Tahiri, Margherita Duca, L. M. C. Marc Mouthaan, Simona Bianca, Marco van den Noort, Bert Poolman, Martin D. Witte, Adriaan J. Minnaard|2020|Org.Lett.|22|5622|doi:10.1021/acs.orglett.0c0198
CCDC 1995088: Experimental Crystal Structure Determination
No full textRelated Article: Nittert Marinus, Nabil Tahiri, Margherita Duca, L. M. C. Marc Mouthaan, Simona Bianca, Marco van den Noort, Bert Poolman, Martin D. Witte, Adriaan J. Minnaard|2020|Org.Lett.|22|5622|doi:10.1021/acs.orglett.0c0198
Site-Selective Oxidation & Further Modification of Unprotected Carbohydrates
Full text linkCarbohydrates are the most abundant molecules in nature and play a crucial role in living organisms. However, unravelling the structure and/or the biological function of carbohydrates is a formidable challenge. They are structurally very complex and contain a large number of reactive groups. In order to study carbohydrates, chemical syntheses and chemical modifications of carbohydrates are needed.In our research group, we study a reaction that can transform a single alcohol functionality of a carbohydrate to a ketone group. This transformation can also be described as the selective oxidation of carbohydrates. This is a valuable transformation because the ketone resulting from oxidation allows further modifications in the presence of alchols. During my PhD I have applied the selective oxidation to convert a sugar molecule into new building blocks. In addition, the reaction was applied to aminoglycoside antibiotics, which resulted into seven new antibiotic derivatives. Finally, the selective oxidation reaction was used in a sequence of chemical reactions to prepare the natural product Dissectol A
