70 research outputs found
Operations on Intuitionisitc Fuzzy Soft Sets Based on First Zadeh's Logical Operators
No full textIn this paper, we have defined First Zadeh's intuitionistic fuzzy conjunction and intuitionistic fuzzy disjunction of two intuitionistic fuzzy soft sets. The author also defined some of their basic properties of intuitionistic fuzzy disjunction and conjunction with some examples. Nithya. A "Operations on Intuitionisitc Fuzzy Soft Sets Based on First Zadeh's Logical Operators" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-1 , December 2018, URL: https://www.ijtsrd.com/papers/ijtsrd18986.pd
Erratum: SDCF: A software-defined cyber foraging framework for cloudlet environment,” IEEE Trans. Netw. Service Manag. (2020) 17:4 (2423–2435) DOI: 10.1109/TNSM.2020.3015657)
No full textIn the above article [1], the corresponding author was incorrectly identified. The corresponding author is the first author, S. Nithya
Interaction of TNF with angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats.
No full textRecent evidence suggests that tumor necrosis factor alpha (TNF) and angiotensin II (ANGII) induce oxidative stress contribute to cardiovascular disease progression. Here, we examined whether an interaction between TNF and ANGII contributes to altered cardiac mitochondrial biogenesis and ATP production to cause cardiac damage in rats. Rats received intraperitoneal injections of TNF (30 µg/kg), TNF + losartan (LOS, 1 mg/kg), or vehicle for 5 days. Left ventricular (LV) function was measured using echocardiography. Rats were sacrificed and LV tissues removed for gene expression, electron paramagnetic resonance and mitochondrial assays. TNF administration significantly increased expression of the NADPH oxidase subunit, gp91phox, and the angiotensin type 1 receptor (AT-1R) and decreased eNOS in the LV of rats. Rats that received TNF only had increased production rates of superoxide, peroxynitrite and total reactive oxygen species (ROS) in the cytosol and increased production rates of superoxide and hydrogen peroxide in mitochondria. Decreased activities of mitochondrial complexes I, II, and III and mitochondrial genes were observed in rats given TNF. In addition, TNF administration also resulted in a decrease in fractional shortening and an increase in Tei index, suggesting diastolic dysfunction. TNF administration with concomitant LOS treatment attenuated mitochondrial damage, restored cardiac function, and decreased expression of AT1-R and NADPH oxidase subunits. Mitochondrial biogenesis and function is severely impaired by TNF as evidenced by downregulation of mitochondrial genes and increased free radical production, and may contribute to cardiac damage. These defects are independent of the downregulation of mitochondrial gene expression, suggesting novel mechanisms for mitochondrial dysfunction in rats given TNF
Partition Studies Of Betalains in Aqueous Two Phase Systems
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Isolation and Characterization of Lipolytic and Proteolytic Lactic Acid Bacteria with Antibacterial Properties from Fish Industry Wastes
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Blueberry supplementation attenuates oxidative stress within monocytes and modulates immune cell levels in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled trial
No full textBlueberry supplementation for six weeks significantly attenuated oxidative stress in the monocytes in patients with MetS.</p
Does Outward Foreign Direct Investment Reduce Domestic Investment?: An Industry-Level Analysis
No full textWith the rise of globalisation, countries have become more connected financially and global cross-border investment flows have become more common. FDI is an important form of cross-border flow which is responsible for the spread of technology across countries and is the main source of external finance for emerging countries. In the last two decades, FDI has increased tremendously. But this has been accompanied by fears about outward FDI taking away production activities and jobs away from the home country. I look at how outward FDI affects home country investment. One can intuitively understand that a dollar of money spent abroad means a dollar less to invest in the domestic economy. Based on the theory of the financially constrained firm, I hypothesize that outward FDI reduces domestic fixed capital investment and R&D spending. I also develop a theoretical framework to distinguish the varying effects of outward FDI on domestic investment across traditional and R&D-intensive industries.By using industry-level panel data for 18 OECD countries covering the period 1995-2009, I regressed the shares of Gross Fixed Capital Formation (GFCF) and R&D spending separately on the share of outward FDI both for all industries as well as specifically for traditional and R&D-intensive industries. While, outward FDI had a negative effect on domestic capital investments at the aggregate level, it did not have any significant effect while looking at specific industry types. This could be because of the reduced sample size in the individual types. Outward FDI had a negative effect on domestic R&D spending at the aggregate level and for R&D-intensive industries, but it had a positive effect for traditional industries. Thus, while fears about outward FDI taking away domestic fixed capital investments are valid, outward FDI can have both a positive and negative effect on R&D expenditure, depending on the type of industry. These results can help MNCs make strategic investment decisions taking into account their effect on their home country industry. It can also help policymakers formulate tax and industrial policies to promote home country investments.Management of Technology (MoT
Analysis of distribution of DNA methylation in kidney-renal-clear-cell-carcinoma specific genes using entropy
No full textAbstractDNA Methylation is an epigenetic phenomenon in which methyl groups are added to the cytosines, thereby altering the physio-chemical properties of the DNA region and influencing gene expression. Aberrant DNA methylation in a set of genes or across the genome results in many epigenetic diseases including cancer. In this paper, we use entropy to analyze the extent and distribution of DNA methylation in Tumor Suppressor Genes (TSG's) and Oncogenes related to a specific type of cancer (viz.) KIRC (Kidney-renal-clear-cell-carcinoma). We apply various mathematical transformations to enhance the different regions in DNA methylation distribution and compare the resultant entropies for healthy and tumor samples. We also obtain the sensitivity and specificity of classification for the different mathematical transformations. Our findings show that it is not just the measure of methylation, but the distribution of the methylation levels in the genes that are significant in cancer
Isolation of Methionine Enriched Fraction from Sunflower Protein.
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction
No full textMitochondrial damage is implicated in the progression of cardiac disease. Considerable evidence suggests that proinflammatory cytokines induce oxidative stress and contribute to cardiac dysfunction. This study was conducted to determine whether a TNF-induced increase in superoxide (O(2)(*)(-)) contributes to mitochondrial damage in the left ventricle (LV) by impairing respiratory complex I activity. We employed an electron paramagnetic resonance (EPR) method to measure O(2)(*)(-) and oxygen consumption in mitochondrial respiratory complexes, using an oxygen label. Adult male Sprague-Dawley rats were divided into four groups: control, TNF treatment (ip), TNF+ apocynin (APO; 200 micromol/kg bw, orally), and TNF+ Tempol (Temp; 300 micromol/kg bw, orally). TNF was injected daily for 5 days. Rats were sacrificed, LV tissue was collected, and mitochondria were isolated for EPR studies. Total LV ROS production was significantly higher in TNF animals than in controls; APO or Temp treatment ameliorated TNF-induced LV ROS production. Total mitochondrial ROS production was significantly higher in the TNF and TNF+ APO groups than in the control and TNF+ Temp groups. These findings suggest that TNF alters the cellular redox state, reduces the expression of four complex I subunits by increasing mitochondrial O(2)(*)(-) production and depleting ATP synthesis, and decreases oxygen consumption, thereby resulting in mitochondrial damage and leading to LV dysfunction
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