1,850 research outputs found
Role of natural herbs and phytochemicals to minimize tumor and economic burden in breast cancer treatment
No full textMaria Shoaib,1 Syed Ahsanuddin Ahmed21Dow Medical College, Dow University of Health Sciences, Karachi, 2Sindh Medical College, Jinnah Sindh Medical University, Karachi, PakistanWe read the article “Economic burden related to chemotherapy-related adverse events in patients with metastatic breast cancer in an integrated health care system” by Rashid et al with great interest and would like to add some views in its support.1View the original paper by Rashid and colleague
Therapeutic deep brain stimulation worsening dysprosody in Parkinson’s disease – an unexplored entity
No full textMaria Shoaib,1 Muhammad Taimoor Khan2 1Department of Medicine, Dow Medical College, Karachi, Pakistan; 2Department of Neurology, Charleston Area Medical Center/West Virginia University, Charleston, WV, USA We read this article, “Altered emotional recognition and expression in patients with Parkinson’s disease” by Jin et al1 with great interest and appreciate the novel information provided on altered emotional processing in pre-deep brain stimulation (DBS) Parkinson’s disease (PD) patients and we would like to add our feedback on the role of DBS on nonmotor and emotional components of PD.View the original paper by Jin and colleagues. 
Assessment of poststroke mania and diagnosis
No full textMaria Shoaib,1 Muhammad Aadil2 1Department of Medicine, DOW Medical College, Karachi, Pakistan; 2Department of Psychiatry, Rush University Medical Center, Chicago, IL, USAWe would like to applaud the authors of the case report “Post-stroke emotional incontinence or bipolar disorder?” which highlights a rare yet treatable condition of mania and emotional incontinence after a cerebrovascular accident. We would like to add our views regarding poststroke mania supporting the significant psychiatric distress patients suffer. As the review mentions, psychiatric sequelae of stroke and cerebrovascular disease include anxiety, psychosis, posttraumatic stress disorder (PTSD), and poststroke depression (PSD).1 This case report also mentions development of treatment response to selective serotonin reuptake inhibitors, which also shows that poststroke emotional incontinence is related predominantly to serotonergic system dysfunction.2View the original paper by Mnif and colleagues
Physicians’ attitude, belief and practice of complementary alternative medication use
No full textMaria Shoaib,1 Muhammad Farhan Khaliq2 1Department of Medicine, Dow Medical College, Karachi, Pakistan; 2Department of Internal Medicine, Charleston Area Medical Centre, West Virginia University, Charleston Division, Charleston, WV, USAWe read the article “Association between belief and attitude toward preference of complementary alternative medicine use” by Islahudin et al with great interest and wish to express our views on this paper. Complementary alternative medication use is indeed on a rising trend as a safer alternative to the conventional medicine either to prevent or to treat health concerns.1 The authors addressed very well toward the patients’ perspective; hence, we feel to add a few points from a physicians’ point of view and the need to sync conventional and complementary medications for further improvised patient care.View the original paper by Islahudin and colleagues. 
Improving Visual Place Recognition Performance by Maximising Complementarity
No full textVisual place recognition (VPR) is the problem of recognising a previously visited location using visual information. Many attempts to improve the performance of VPR methods have been made in the literature. One approach that has received attention recently is the multi-process fusion where different VPR methods run in parallel and their outputs are combined in an effort to achieve better performance. The multi-process fusion, however, does not have a well-defined criterion for selecting and combining different VPR methods from a wide range of available options. To the best of our knowledge, this paper investigates the complementarity of state-of-the-art VPR methods systematically for the first time and identifies those combinations which can result in better performance. The letter presents a well-defined framework which acts as a sanity check to find the complementarity between two techniques by utilising a McNemar's test-like approach. The framework allows estimation of upper and lower complementarity bounds for the VPR techniques to be combined, along with an estimate of maximum VPR performance that may be achieved. Based on this framework, results are presented for eight state-of-the-art VPR methods on ten widely-used VPR datasets showing the potential of different combinations of techniques for achieving better performance
Development of a non-living model system for cell membranes and investigation of its mechanical and tribological properties
No full textWhile our exposure to nanomaterials (NMs) has increased with advancements in nanotechnology, understanding harmful effects of such materials on humans is still wanting. Here we have proposed and developed a non-living model system for cell membranes which is suitable for elucidating interactions between NMs and living cells. In contrast to existing model systems for cell membranes, PAAm hydrogel was used as soft support for the lipid. Grafting of lipid with PAAm was achieved through layer by layer deposition of alternating poly(allylamine hydrochloride) (PAH)and poly(sodium 4-styrenesulfonate) (PSS) polyelectrolyte multilayers (PEM). Single step bilayer formation was observed under QCM on the PAAm-PEM support owing to high electrostatic interactions between the PEM and lipid vesicles with frequency and dissipation changes of ~-30 Hz and ~0.8x10-6, respectively. It is also shown that the PEM architecture is robust and reproducible on gels of different elastic modulus. AFM images confirm bilayer formation on top of PAAm-PEM supports with uniform bilayer patches of ~ 0.5 μm. AFM indentation experiments show significant differences in the elastic modulus and adhesion forces for systems with soft underlying supports compared to systems having a hard substrate. The physiological relevance of the developed system is clear from its mechanical characterization via AFM, where the system undergoes considerable deformation before and after bilayer rupture. This behavior is similar to behavior of real cells, in which deformation of cytoskeleton is dominant over that of the cell membrane. The model cell membrane system was also used to study shear forces at the interface of the lipid bilayer on hydrogel, which gave insights into the frictional behavior of the system and its mechanical interactions with nanoprobes.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-12-01The student, Tooba Shoaib, accepted the attached license on 2016-07-22 at 08:53.The student, Tooba Shoaib, submitted this Thesis for approval on 2016-07-22 at 10:40.This Thesis was approved for publication on 2016-07-22 at 15:06.DSpace SAF Submission Ingestion Package generated from Vireo submission #10071 on 2017-02-28 at 14:35:29Made available in DSpace on 2017-03-01T16:36:31Z (GMT). No. of bitstreams: 2
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Previous issue date: 2016-07-22Embargo set by: Seth Robbins for item 98552
Lift date: 2019-03-01T16:37:19Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 98552 on 2019-03-02T10:15:17Z
"Medical students" burn out – need of student mentor and support groups and emotional resilience skills training to be a part of medical school curriculum
No full textMaria Shoaib,1 Anoshia Afzal,1 Muhammad Aadil,2 1Department of Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan; 2Department of Psychiatry, Rush University Medical Center, Chicago, IL, USA We would like to applaud the authors of the article “Potential predictors of psychological distress and well-being in medical students: a cross-sectional pilot study” for conducting a cross-sectional pilot study to understand the predictors of psychological distress and well-being and for assessing their extent using latest scales that have not been extensively used for this purpose before.1 We would like to add some views in its support. View the original paper by Bore and colleagues. 
Cerebral malaria: insight into pathogenesis, complications and molecular biomarkers
No full textFarah Hafiz Yusuf,1 Muhammad Yusuf Hafiz,1 Maria Shoaib,1 Syed Ahsanuddin Ahmed2 1Department of Medicine, Dow Medical College, Dow University of Health Sciences, 2Department of Medicine, Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan Abstract: Cerebral malaria is a medical emergency. All patients with Plasmodium falciparum malaria with neurologic manifestations of any degree should be urgently treated as cases of cerebral malaria. Pathogenesis of cerebral malaria is due to damaged vascular endothelium by parasite sequestration, inflammatory cytokine production and vascular leakage, which result in brain hypoxia, as indicated by increased lactate and alanine concentrations. The levels of the biomarkers’ histidine-rich protein II, angiopoietin-Tie-2 system and plasma osteoprotegrin serve as diagnostic and prognostic markers. Brain imaging may show neuropathology around the caudate and putamen. Mortality is high and patients who survive sustain brain injury which manifests as long-term neurocognitive impairments. Keywords: cerebral malaria, neurologic manifestations, mortality, biomarkers, brain imagin
A stabilized discontinuous Galerkin method for variational embedding of physics-based data
No full textA stabilized variational framework that admits overlapping as well as non overlapping coupling of domains for a variety of Partial Differential Equations (PDEs) is employed in this work. This method accommodates non-matching meshes across the interfaces between the subdomain boundaries and allows for sharp changes in mechanical material properties. Interface coupling operators that emanate via embedding of Discontinuous Galerkin ideas in the continuous Galerkin framework provide a unique avenue to embed physics-based data in the modeling and analysis of the system. Physics-based data, either in discrete or in distributed form can be embedded via the interface operators that are otherwise devised to enforce continuity of the fields across internal discontinuities. The least-squares form of the interface coupling operators is exploited for its inherent linear regression type structure, and it is shown that it helps improve the overall accuracy of the numerical solution. Method is applicable to multi-PDE class of problems wherein different PDEs are operational on adjacent domains across the common interface. The method also comes equipped with a residual based error estimation method which is shown to be applicable to test problems employed. Different test cases are employed to investigate the mathematical attributes of the method.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-08-01The student, Shoaib Ahmad Goraya, accepted the attached license on 2019-07-12 at 16:53.The student, Shoaib Ahmad Goraya, submitted this Thesis for approval on 2019-07-12 at 16:54.This Thesis was approved for publication on 2019-07-15 at 14:47.DSpace SAF Submission Ingestion Package generated from Vireo submission #14260 on 2019-11-26 at 14:03:50Made available in DSpace on 2019-11-26T20:59:45Z (GMT). No. of bitstreams: 3
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Previous issue date: 2019-07-15Embargo set by: Seth Robbins for item 113082
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 113082 on 2021-11-27T10:15:34Z
Exploring Object-Centric and Scene-Centric CNN Features and their Complementarity for Human Rights Violations Recognition in Images
No full textIdentifying potential abuses of human rights through imagery is a novel and challenging task in the field of computer vision, that will enable to expose human rights violations over large-scale data that may otherwise be impossible. While standard databases for object and scene categorisation contain hundreds of different classes, the largest available dataset of human rights violations contains only 4 classes. Here, we introduce the ‘Human Rights Archive Database’ (HRA), a verified-by-experts repository of 3050 human rights violations photographs, labelled with human rights semantic categories, comprising a list of the types of human rights abuses encountered at present. With the HRA dataset and a two-phase transfer learning scheme, we fine-tuned the state-of-the-art deep convolutional neural networks (CNNs) to provide human rights violations classification CNNs (HRA-CNNs). We also present extensive experiments refined to evaluate how well object-centric and scene-centric CNN features can be combined for the task of recognising human rights abuses. With this, we show that HRA database poses a challenge at a higher level for the well studied representation learning methods, and provide a benchmark in the task of human rights violations recognition in visual context. We expect this dataset can help to open up new horizons on creating systems able of recognising rich information about human rights violations
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