10 research outputs found
Endogenously produced adiponectin protects cardiomyocytes from hypertrophy by a PPARγ-dependent autocrine mechanism
No full text In experimental animal and cell culture models, activation of peroxisome proliferator-activated receptor (PPAR) γ in heart has been shown to have beneficial effects on cardiac function and cardiomyocyte physiology. The goal of this study was to identify the signaling pathway by which PPARγ activation protects cardiomyocytes from the deleterious effects of hypertrophic stimuli. In primary cardiomyocyte cultures, we found that genetic or pharmacological activation of PPARγ protected cells from cardiac hypertrophy induced by α-adrenergic stimulation. Examination of gene expression in these cells revealed a surprising increase in the expression of adiponectin in cardiomyocytes and secretion of the high-molecular-weight form of the hormone into media. Using RNAi to block PPARγ-induced adiponectin production or adiponectin receptor gene expression, we found that the PPARγ-mediated anti-hypertrophic effect required cardiomyocyte-produced adiponectin, as well as an intact adiponectin signaling pathway. Furthermore, mice expressing constitutive-active PPARγ and cardiomyocyte specific adiponectin expression were protected from high-fat diet-induced cardiac hypertrophy and remodeling. These findings demonstrate that functional adiponectin hormone can be produced from the heart and raise the possibility that beneficial effects of PPARγ activation in heart could be due in part to local production of adiponectin that acts on cardiomyocytes in an autocrine manner. </jats:p
Supplemental Material, sj-docx-1-ptd-10.1177_08968608231214143 - Predicting transfer to haemodialysis using the peritoneal dialysis surprise question
No full textSupplemental Material, sj-docx-1-ptd-10.1177_08968608231214143 for Predicting transfer to haemodialysis using the peritoneal dialysis surprise question by Ayesha Anwaar, Sai Liu, Maria Montez-Rath, Hatsumi Neilsen, Sumi Sun, Graham Abra, Brigitte Schiller and Wael F Hussein in Peritoneal Dialysis International</p
Halirages helgae Ringvold & Tandberg 2014, sp. nov.
No full text<i>Halirages helgae</i> sp. nov. <p>urn:lsid:zoobank.org:act: 94170470-2502-4808-A77B-248EEACD8EF6</p> <p>Figs 2–7</p> Diagnosis <p>Head with short rostrum, anteroventral corner with small projecting tooth. Eyes present, but very small, whitish in alcohol. Article 3 of mandible palp about half the length of article 2. Pereonite 7, and in large animals (> 11 mm) also pereonite 6 and pleonite 2, with weakly bilobed posterior margin. Length of dactylus on first and second gnathopod about half that of propodus palm. Carpus longer than propodus. Epimeral plate 2 with small tooth posteroventrally, and epimeral plate 3 with posterior corner rounded. Uropods 1 and 2 biramous, with strong setae. Telson entire, longer than wide, acute.</p> Etymology <p>The species is named in memory of Helga Ringvold, for encouraging her children in their future endeavours.</p> Material examined <p> <b>Holotype</b></p> <p> NORWAY: ♀, 10.5 mm long, R / V <i>G.O. Sars</i>, cruise 11408, st. 276-030A, Nordland, slope of Moskenesgrunnen, 68°28.86’ N, 10°55.81’ E, 1292 m, mud, –0,87 °C, salinity 34.92‰, RP sledge, leg. H. Ringvold (ZMBN 90142).</p> <p> <b>Paratypes</b></p> <p> NORWAY: 4 ♀♀, 9–13 mm long, R / V <i>G.O. Sars</i>, cruise 10408, st. 198-003A, Troms, slope of Mulegga, 70°14.67’ N, 16°44.52’ E, 1532 m, cobbles, –0.78°C, salinity 34.92‰ (ZMBN 88021–88024). A total of 31 slides has been made of the holotype and paratypes.</p> <p> <b>Additional material</b></p> <p> NORWAY: 1 ♀, 10 mm long, R / V <i>G.O. Sars</i>, cruise 11109, st. 487-157, Nordland, W of Lofoten, 69°04.13’ N, 12°26.91’ E, 2609 m, mud, clay and gravel, –0.82°C, salinity 34.89‰; 35 ♀♀ (6 with eggs; 3 juveniles), 3–13 mm long, R / V <i>G.O. Sars</i>, cruise 10408, st. 198-003A, Troms, slope of Mulegga, 70°14.67’ N, 16°44.52’ E, 1532 m, cobbles, –0.78°C, salinity 34.92‰; 6 ♀♀, 5–11 mm long, R / V <i>G.O. Sars</i>, cruise 11109, st. 444-148, Troms, slope of Eggagrunnen, 71°44.4’ N, 15°14.22’ E, 997 m, cobbles, –0.73°C, salinity 34.88‰; 3 ♀♀, 7–11 mm, R / V <i>G.O. Sars</i>, cruise 11010, st. 542-357, Troms, Vesthola, Egga, 70°23.69’ N, 16°58.86’ E, 1189 m, gravelly sand and sandy mud, –0.66°C, salinity 34.9‰.</p> Description <p>BODY. Up to 13 mm long. Pereonites 1-5 smooth, dorsal posterior margin of pereonite 7 slightly bilobed (Fig. 2B) (also on pereonite 6 and pleonite 2 on some large specimens greater than 11 mm long). Head (Fig. 3A). Rostrum short; corner of cephalic lobe with small projecting tooth; eye small (can be difficult to see in preserved specimens), reniform.</p> <p>ANTENNA 1 (Fig. 3B). Flagellum broken in all examined specimens. Peduncle of article 1 longer than article 2, article 3 about ⅓ length of article 2, which has a posterodistal process. Eight articles remaining in flagellum, with one short seta on three of them.</p> <p>ANTENNA 2 (Fig. 3C). Flagellum broken in all examined specimens. Article 5 longer than articles 3–4 combined, articles 4–5 with short spines, article 5 with a posterodistal process.</p> <p>LABRUM (Fig. 3D). Rounded apically and acute dorsally.</p> <p>LABIUM (Fig. 3E). With small inner lobes.</p> <p>MANDIBLE (Fig. 4D). Incisor process with 4 blunt teeth; lacinia mobilis with 4 teeth on left molar; molar triturative, with ridged grinding surface and with row of lateral spines; palp 3-articulate, with elongate article 2, articles 2–3 with elongate setae on ventral margin. Article 3 short.</p> <p>MAXILLA 1 (Fig. 4A). Inner plate with 9 plumose setae; outer plate with 11 spines of which 5–6 are bifurcate; palp 2-articulate and well developed, article 1 expanded distally, article 2 tapering and with 2 rows of 5–6 spines, one row apically and the other slightly lower. Left article 2 with long marginal</p> <p>spines and margino-facial setae, right article 2 with a row of 6–7 stout, conical marginal spines with margino-facial row of setae.</p> <p>MAXILLA 2 (Fig. 4B). Outer plate longer than inner plate, both plates with long setae apically. Upper and inner plate with posterior setae, on inner plate the setae also reach posterodistal area.</p> <p>MAXILLIPED (Fig. 4C). Broad and covered with numerous setae; inner plate short with short setae apically and on inner margins, three apical teeth; outer plate slender with long setae apically and on inner margins; palp articles 2–3 elongate, article 2 longest; article 3 with long setae apically and on inner margins; dactylus stout, about half length of article 3.</p> <p>GNATHOPODS 1 AND 2 (Fig. 5A and 5B). Quite similar in shape: both coxae sub-quadrate and smooth; bases rectangular with a few short setae; ischia narrow; meri longer than wide, with group of setae apically; propodi shorter than carpi, subovate, carpi subtriangular with rows of setae along posterior margin, propodi subtriangular. Gnathopod 1 carpus length / width ratio 3.0, of propodus 1.9. Gnathopod 2 carpus length / width ratio 2.7, of propodus 1.9; carpus setae along hind margins and palms, with</p> <p>groups of setae along inner face, palm of gnathopods 1 and 2 similar and slightly excavate; dactyli on both gnathopods about half length of propodus palm, with dentate inner margin.</p> <p>PEREOPODS 3–7 (Fig. 6A–E). Coxa 3 sub-quadrate and smooth, coxa 4 posteriorly excavate, coxae 5 and 6 longer than wide, coxa 7 elliptic and smallest of all coxae; bases of pereopods 5–7 broad and posteriorly smooth. Articles of pereopods 4–7 missing on all specimens except paratype 2, which has one pereopod 7 that includes carpus; ischium short and square-shaped, merus with setae along both margins and long setae apically, carpus with setae on both margins, 7 times as long as wide, and 1.5 times as long as merus.</p> <p>UROPODS 1 AND 2 (Fig. 7A and 7B). With spines on both margins of peduncles and rami. Rami damaged on all specimens.</p> <p>UROPOD 3. Missing on all specimens.</p> <p>TELSON. Entire, longer than wide, triangular with blunt tip (Fig. 7C).</p> <p>EPIMERAL PLATES. Epimeral plate 1 posteriorly rounded, posteroventral corner obtusely angular; epimeral plate 2 with small, posteroventral tooth; epimeral plate 3 with posteroventral corner rounded and with posterior border smooth and nearly straight (Fig. 7D).</p> <p>COLOUR PATTERN. Colour of live specimens unrecorded.</p> Distribution <p> This species has only been found in the northeast Atlantic, off northern Norway. It has been recorded at some of MAREANO’s deepest stations, from 997 to 2,609 m, and only in cold water masses (NSAIW, Norwegian Sea Arctic Intermediate Water) (Buhl-Mortensen <i>et al.</i> 2012), with mud as the dominant sediment.</p>Published as part of <i>Ringvold, Halldis & Tandberg, Anne Helene Solberg, 2014, A new deepwater species of Calliopiidae, Halirages helgae (Crustacea, Amphipoda), with a synoptic table to Halirages species from the northeast Atlantic, pp. 1-13 in European Journal of Taxonomy 98</i> on pages 3-10, DOI: 10.5852/ejt.2014.98, <a href="http://zenodo.org/record/3838954">http://zenodo.org/record/3838954</a>
Prevalence of risk factors for adverse events, and evidence of their management among participants with CKD.
No full textOf the 558 and 122 participants with CKD in CARRS and MASALA respectively, 430 (77%) and 119 (98%) had complete data on prevalence of risk factors for progression of CKD and/or cardiovascular events. While 43% of participants with CKD in CARRS had diabetes, only 17% were on medications and only 2% (i.e., 4% of those with CKD and diabetes) had A1c < 7.0.</p
Prevalence of chronic kidney disease in the CARRS and MASALA studies.
No full textPrevalence of chronic kidney disease in the CARRS and MASALA studies.</p
Harmonizing measures from the CARRS and MASALA studies.
No full textHarmonizing measures from the CARRS and MASALA studies.</p
Prevalence of chronic kidney disease and risk factors for its progression: A cross-sectional comparison of Indians living in Indian versus U.S. cities - Fig 2
No full textPrevalence difference in CKD in the MASALA study from the CARRS study (A) men and (B) women. We present prevalence difference in CKD 1. Unadjusted, 2. Adjusted for age, and 3. Adjusted for age, waist-to-height ratio, and diabetes. Prevalence difference in overall CKD and albuminuria among men in CARRS and MASALA was negligible in all three models; prevalence of eGFR 2 was slightly higher in men in CARRS. Unadjusted prevalence in overall CKD and albuminuria among women in MASALA was 11.1% and 11.8% higher respectively compared with CARRS; adjusting for diabetes and waist-to-height ratio did not attenuate this prevalence difference.</p
Demographic, anthropometric, laboratory and disease status in the CARRS and MASALA studies, 2010–2013.
No full textDemographic, anthropometric, laboratory and disease status in the CARRS and MASALA studies, 2010–2013.</p
A new deepwater species of Calliopiidae, Halirages helgae (Crustacea, Amphipoda), with a synoptic table to Halirages species from the northeast Atlantic
No full textHalirages helgae sp. nov. is recorded from the shelf slopes of the Norwegian Sea at depths of 1000 to 2600 m in the Arctic cold water masses. A total of 50 specimens were found at five stations. The
species differs from other known species in the genus Halirages Boeck, 1871 by the bilobed posterior margin of pereonite 7. A synoptic table to the northeast Atlantic species of Halirages is provided
Prevalence of chronic kidney disease and risk factors for its progression: A cross-sectional comparison of Indians living in Indian versus U.S. cities.
No full textBackgroundWhile data from the latter part of the twentieth century consistently showed that immigrants to high-income countries faced higher cardio-metabolic risk than their counterparts in low- and middle-income countries, urbanization and associated lifestyle changes may be changing these patterns, even for conditions considered to be advanced manifestations of cardio-metabolic disease (e.g., chronic kidney disease [CKD]).Methods and findingsUsing cross-sectional data from the Center for cArdiometabolic Risk Reduction in South Asia (CARRS, n = 5294) and Mediators of Atherosclerosis in South Asians Living in America (MASALA, n = 748) studies, we investigated whether prevalence of CKD is similar among Indians living in Indian and U.S. cities. We compared crude, age-, waist-to-height ratio-, and diabetes- adjusted CKD prevalence difference. Among participants identified to have CKD, we compared management of risk factors for its progression. Overall age-adjusted prevalence of CKD was similar in MASALA (14.0% [95% CI 11.8-16.3]) compared with CARRS (10.8% [95% CI 10.0-11.6]). Among men the prevalence difference was low (prevalence difference 1.8 [95% CI -1.6,5.3]) and remained low after adjustment for age, waist-to-height ratio, and diabetes status (-0.4 [-3.2,2.5]). Adjusted prevalence difference was higher among women (prevalence difference 8.9 [4.8,12.9]), but driven entirely by a higher prevalence of albuminuria among women in MASALA. Severity of CKD--i.e., degree of albuminuria and proportion of participants with reduced glomerular filtration fraction--was higher in CARRS for both men and women. Fewer participants with CKD in CARRS were effectively treated. 4% of CARRS versus 51% of MASALA participants with CKD had A1c ConclusionsPrevalence of CKD among Indians living in Indian and U.S. cities is similar. Persons with CKD living in Indian cities face higher likelihood of experiencing end-stage renal disease since they have more severe kidney disease and little evidence of risk factor management
