299 research outputs found

    Supplemental material for Safety of vedolizumab in liver transplant recipients: A systematic review

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    Supplemental Material for Safety of vedolizumab in liver transplant recipients: A systematic review by Marco Spadaccini, Alessio Aghemo, Flavio Caprioli, Ana Lleo, Federica Invernizzi, Silvio Danese and Maria F Donato in United European Gastroenterology Journal</p

    Identification of a gene (arpU) controlling muramidase-2 export in Enterococcus hirae

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    Muramidase-2 of Enterococcus hirae is a 74-kDa peptidoglycan hydrolase that plays a role in cell wall growth and division. To study its regulation, we isolated a mutant defective in muramidase-2 release under certain growth conditions. This mutant had cell walls which apparently lacked 74-kDa muramidase-2 but which accumulated two proteolytic fragments of 32 and 43 kDa, which exhibited muramidase-2 activity in the membrane fraction. By complementation cloning, we identified a 2.6-kb fragment of the E. hirae chromosome containing a gene cluster coding for proteins of 58 to 137 amino acids. One of these genes (arpU), which encoded a 15.9-kDa protein, was shown to complement the defect of the A9 mutant in trans. We propose that this gene may be involved in the regulation of muramidase-2 export

    Application of space technologies to the surveillance and modelling of waterborne diseases.

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    Earth observing satellites, global positioning and geographic information systems are new tools that currently enable the scientific community to integrate ecological, environmental and medical data to develop predictive models for disease surveillance and modelling. A number of investigators have explored remotely sensed environmental factors that might be associated with waterborne disease ecology and human transmission risk. However, health specialists have not been fully familiarized with the capabilities of space technology, and in some cases it has not proved to be the wonder tool that scientists expected. New satellite capabilities and new sensors now allow exploration of risk factors previously beyond the capabilities of remote sensing and put researchers in a position to analyze the effects of environment on disease outbreaks
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