37 research outputs found

    Sensitivity of number of spikes recovered to the prior on spike rate.

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    <p>(<b>A</b>) Results for two example cells, one well-isolated (blue), and one poorly isolated (red). Adjusting the Bernoulli prior parameter (for each cell individually) alters the threshold used for spike identification (see Methods), which leads to an increase or decrease in the number of estimated spikes. (<b>B</b>) Simulation of detection of a scalar signal contaminated by Gaussian noise, for two different SNRs. Insets indicate histograms of noise observations (black) and signal observations (gray). The number of detections (“hits” plus “false positives”) varies with the choice of threshold, and the shape of the curve depends on the SNR. (<b>C</b>) Error rates (“misses” plus “false positives”) as a function of threshold for the simulations in (B).</p

    Effect modification by vigorous physical activity.

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    <p>MetS-W: Metabolic syndrome according to World Health Organization. MetS-I: Metabolic syndrome according to International Diabetes Federation. MetS-A: Metabolic syndrome according to Adult Treatment Panel-III criteria. Active defined as vigorous physical activity ≥30 minutes per week. Inactive defined as vigorous physical activity <30minutes per week. Fully adjusted models include age, sex, educational attainment, neighbourhood socio-economic index, occupational exposure to vapours, gases, dusts and fumes, smoking status, smoked pack-years, exposure to passive smoke, consumption of fruits and raw vegetables, and body mass index. PM<sub>10</sub>: particulate matter <10μm in diameter from all sources. All analyses were done with four-hour fasting participants. Participants’ study area was treated as a random effect in all models. Odds ratio values refer to increments of 10μg/m<sup>3</sup> in PM<sub>10</sub> exposure. Total N = 3684; N(physically-active) = 2115.</p

    Effect modification by diabetes status.

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    <p>MetS-W: Metabolic syndrome according to World Health Organization. MetS-I: Metabolic syndrome according to International Diabetes Federation. MetS-A: Metabolic syndrome according to Adult Treatment Panel-III criteria. Fully adjusted models include age, sex, educational attainment, neighbourhood socio-economic index, occupational exposure to vapours, gases, dusts and fumes, smoking status, smoked pack-years, exposure to passive smoke, consumption of fruits and raw vegetables, physical activity and body mass index. PM<sub>10</sub>: particulate matter <10μm in diameter from all sources. All analyses were done with four-hour fasting participants. Participants’ study area was treated as a random effect in all models. Odds ratio values refer to increments of 10μg/m<sup>3</sup> in PM<sub>10</sub> exposure. Total N = 3684; N(diabetes) = 144.</p

    Annual trajectories of working memory, complex working memory, and inattentiveness in children attending schools with low and high average road traffic noise levels (LAeq, dB) outdoors in street and playground or indoors in 1 classroom (indoor level) or in each child’s classroom considering change of room between years (individual indoor level).

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    Y axis: point estimate (beta coefficient), error bars (95% confidence intervals). Predictions for working memory (2-back number stimuli, d′), complex working memory (3-back number stimuli, d′), and inattentiveness (HRT-SE, ms) adjusted at the means of age, sex, corresponding road traffic noise indicator, age*road traffic noise indicator, maternal education, socioeconomical vulnerability index at home and outdoor or indoor TRAP at school for models including outdoor or indoor noise levels, respectively. Child and school included as nested random effects. d′: detectability, a higher value indicates better working memory; HRT-SE: hit reaction time standard error, a higher value indicates greater inattentiveness; LAeq: A-weighted equivalent noise levels; TRAP: traffic-related air pollution.</p

    Sensitivity Analyses.

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    <p>Fully adjusted models include age, sex, educational attainment, neighbourhood socio-economic index, occupational exposure to vapours, gases, dusts and fumes, smoking status, smoked pack-years, exposure to passive smoke, consumption of fruits and raw vegetables, physical activity and body mass index. MI: multiple imputations. IPW: inverse probability weighting. PM<sub>10</sub>: particulate matter <10μm in diameter from all sources. NO<sub>2</sub>: nitrogen dioxide. OR: odds ratio. CI: confidence interval. OR refer to increments of 10μg/m<sup>3</sup> in PM<sub>10</sub>, and NO<sub>2</sub> exposure respectively. All analyses were done with four-hour fasting participants.</p><p>Sensitivity Analyses.</p
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