63 research outputs found
Photolyses study of tert-Butyl ([plus])-3-(phenylmethylene) cyclobutanecarboxylate
No full textMade available in DSpace on 2014-03-20T21:26:43Z (GMT). No. of bitstreams: 2
license.txt: 4923 bytes, checksum: 3568ab34bde24044ec8ea05b1192aa03 (MD5)
30112111735855_opt.pdf: 2398832 bytes, checksum: d357f1608f51e0da01c3fc6a46c859ca (MD5)
Previous issue date: 1992Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2014-03-20T21:48:03Z
Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:37:37-05:00
Original Data
Group with Access UIUC Users [automated]
Release Date: none
Reason: Theses restricted to UIUC community onlyTheses restricted to UIUC community onlyU of I OnlyThesis (B.S.) in Chemistry--University of Illinois at Urbana-Champaign, 1992.Includes bibliographical references (leaf 14
Experimental Assessment of Seismic Pile-Soil Interaction
No full textPhysical modeling has long been established as a powerful tool for studying seismic pile-soil-superstructure interaction. This chapter presents a series of 1-g shaking table tests aiming at clarifying fundamental aspects of kinematic and inertial interaction effects on pile-supported systems. Pile models in layered sand deposits were built in the laboratory and subjected to a wide set of earthquake motions. The piles were densely instrumented with accelerometers and strain gauges; therefore, earthquake response, including bending strains along their length, could be measured directly. Certain broad conclusions on kinematic and inertial SSI effects on this type of systems are drawn
Abstract 649: Emigrant pre-REP tumor infiltrating lymphocytes profoundly differ from remnant T-cells
No full textAbstract
Adoptive T cell therapy with autologous tumor infiltrating lymphocytes (TIL) provides up to 56% objective response rates and a complete response in 24% of patients with metastatic melanoma. The process of generating TIL from resected tumor involves morcellating the tumor into 1-3 mm3 fragments and expanding TIL in the presence of Interleukin 2 (IL-2) in a pre-Rapid Expansion Protocol (pre-REP). During the ‘pre-REP’, tumor-resident immune cells emigrate (eTIL) and proliferate. The length of the pre-REP varies between 11-21 days, depending on cell growth. Residual tumor fragments (remnants) are discarded and the expanded eTIL are subjected to a Rapid Expansion Protocol (REP) with irradiated PBMC feeders, anti-CD3 and IL-2. Viable cells remaining in the tumor remnants (rTIL) following the pre-REP were investigated to assess their function and phenotype. We evaluated and compared the rTIL and eTIL in melanoma, breast, renal, pancreatic, lung and colorectal tumors (n=9). Tumor rTIL are consistently phenotypically distinct from eTIL, as determined by differential expression of various markers (Table 1). The fundamental differences in rTIL were: Increased CD69+ (7 fold MFI in CD4+) (p<.001); diminished LAG3 (2 fold MFI in CD8) (p<.05); TIM3 (3 and 2 fold MFI in CD8 and CD4 respectively) (p<.05/.01); CD154 (3 fold MFI in CD4) (p<.01); and CD56 (5%) (p<.05). Surprisingly, a REP of rTIL and eTIL resulted in comparable expansion. The phenotypic signature of TIL was sustained post-REP with fidelity of the individual expression of LAG3, Tim3, and CD28. These studies have identified significant differences in the biology of cell populations in terms of tissue-resident T cells and the signals associated with emigration and retention. These data provide additional insights on the individual TIL populations that could be utilized for adoptive T-cell therapy in patients and raise important questions about the nature of tissue-resident T cells in sites of chronic inflammation such as tumor.
Table 1:Tumor resident remnant T cells are phenotypically distinct from emigrating T cells (N=9)Marker ExpressionLAG3 (CD8/ CD4) MFITim3 (CD8/ CD4) MFIPD-1 (CD8/ CD4) %CD69 (CD8/ CD4) MFICD154 (CD8/ CD4) MFICD28 (CD8/ CD4) MFICD57 (CD8/ CD4) %CD56%eTIL507/ 1442832/ 175636.95/ 471320/ 15431498/ 37511163/ 503618.76/ 19.65.615rTIL209/ 106877/ 74242.8/ 483437/ 223.41034/ 1167458.3/ 27959.16/8.51.027*P-values(CD8/ CD4) 0.05/ 0.210.05/ 0.010.38/ 0.890.11/ 0.0010.55/ 0.010.05/ 0.110.05/ 0.060.05 _______
Citation Format: Michelle R. Simpson-Abelson, Christopher Mosychuk, Maria Fardis, Michael T. Lotze. Emigrant pre-REP tumor infiltrating lymphocytes profoundly differ from remnant T-cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 649. doi:10.1158/1538-7445.AM2017-649</jats:p
Experimental assessment of seismic pile-soil interaction
No full text© Springer International Publishing Switzerland 2014. Physical modeling has long been established as a powerful tool for studying seismic pile-soil-superstructure interaction. This chapter presents a series of 1-g shaking table tests aiming at clarifying fundamental aspects of kinematic and inertial interaction effects on pile-supported systems. Pile models in layered sand deposits were built in the laboratory and subjected to a wide set of earthquake motions. The piles were densely instrumented with accelerometers and strain gauges; therefore, earthquake response, including bending strains along their length, could be measured directly. Certain broad conclusions on kinematic and inertial SSI effects on this type of systems are drawn.status: Publishe
Η συνταγματική προστασία των ατόμων με αναπηρίες στο κοινωνικό κράτος δικαίου και θεσμοί αποκατάστασης
No full textΗ προβληματική της συνταγματικής προστασίας των ατόμων με αναπηρίες στο κοινωνικό κράτος δικαίου, ανεξάρτητα από τα συνταγματικά ζητήματα που θέτει και διατυπώνονται στην παρούσα μελέτη, ωθεί τον συντάκτη προ του σημαντικού έργου της αναζήτησης του καθεστώτος που διέπει τις μειονότητες, τα μέσα καταπολέμησης των διακρίσεων υπό το φως του νομοθέτη και τη συγκριτική ανάλυση των εγχώριων με τους αλλοδαπούς θεσμούς. Η αναπηρία είναι έννοια σχετική, καθότι προσδιορίζεται σε συνάρτηση με τον ορισμό που αποδίδει η κοινωνία στην κανονικότητα. Η συνταγματική κατοχύρωση στο άρθρο 21 του εν ισχύ Συντάγματος ενός συστήματος προστασίας των ατόμων με αναπηρίες , η θεμελίωση των θετικών μέτρων από την ελληνική και την ευρωπαϊκή έννομη τάξη , το κανονιστικό περιεχόμενο των κοινωνικών δικαιωμάτων και ,τέλος, το αγώγιμο των αξιώσεων αποτέλεσαν τους βασικούς άξονες, στους οποίους κινήθηκε η παρούσα μελέτη.The problematic of constitutional protection of disabled people in the welfare state of law, except for the constitutional issues, which the problematic adresses and examines, motivates also the author to search for the regime of minorities, the proper equipment to fight against discriminations, under the secure of legislator, and ,last , the implementation of domestic institutions in comparison with foreign institutions. The meaning of the word disability is relevant, because it depends on the definition, which our society gives to normality. The constitutional protection of disabled people in the article 21 of Greek Constitution, the positive measures, the regulatory content of welfare rights and, last but not least, the enforceability of an obligation are the essentials of my study
Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples
No full textNowadays, increasing extended-spectrum β-lactamase (ESBL)-producing bacteria have become a global concern because of inducing resistance toward most of the antimicrobial classes and making the treatment difficult. In order to achieve an appropriate treatment option, identification of the prevalent species which generate ESBL as well as their antibiotic susceptibility pattern is essential worldwide. Hence, this study aimed to investigate the prevalence of ESBL-producing bacteria and assess their drug susceptibility in Fardis Town, Iran. A total of 21,604 urine samples collected from patients suspected to have urinary tract infection (UTI) were processed in the current study. The antimicrobial susceptibility of the isolates was tested by the disk diffusion method. The ESBL producing bacteria were determined by Double Disc Synergy Test (DDST) procedure. Bacterial growth was detected in 1408 (6.52) cases. The most common bacterial strains causing UTI were found E. coli (72.16), followed by K. pneumoniae (10.3) and S. agalactiae (5.7). Overall, 398 (28.26) were ESBL producer. The highest ESBL production was observed in E. coli, followed by Klebsiella species. ESBL producers revealed a higher level of antibiotic resistance compared with non-ESBLs. In conclusion, ESBL production in uropathogens was relatively high. Carbapenems and Aminoglycosides were confirmed as the most effective treatment options for these bacteria. © 2021, The Author(s)
Abstract CT169: A phase II, multicenter study to assess the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-144) for treatment of patients with metastatic melanoma
No full textAbstract Adoptive cell therapy (ACT) utilizing tumor-infiltrating lymphocytes (TIL) has been employed for years in hundreds of patients with metastatic melanoma and other solid tumors, demonstrating durable and complete responses, even in heavily pretreated patients. Despite the approvals of checkpoint-directed therapies, metastatic melanoma remains an unmet need due to progression subsequent to administration of checkpoints, as well as due to intolerance. The C-144-01 study will enroll metastatic melanoma patients who progressed on anti-PD-1 and BRAF inhibitors if BRAF mutation positive. This phase II trial utilizes a central GMP facility for the manufacture of LN-144 in either a non-cryopreserved generation-1 (Gen-1), or cryopreserved generation-2 (Gen-2) investigational TIL infusion product. The Gen-2 manufacturing process reduces the time required for manufacture of TIL product to 22 days. The process development of cryopreservation for the final LN-144 infusion product incorporates dramatic improvements in the flexibility of scheduling, distribution and delivery required for commercial use. C-144-01 (NCT02360579) is a global phase 2 multicenter, open-label study evaluating the efficacy and safety of autologous TIL (LN-144) therapy for the treatment of patients with advanced metastatic melanoma. The study consists of three treatment cohorts: 30 patients in Cohort 1 will receive a single dose of Gen-1, non-cryopreserved LN-144; 30 patients in Cohort 2 will receive a single dose of Gen-2, cryopreserved LN-144; and up to 10 eligible patients from either Cohort 1 or Cohort 2 may enter a third cohort (Cohort 3) for re-treatment with a second dose of LN-144. The investigational LN-144 TIL infusion product for all cohorts is prepared at the central GMP facility using lymphocytes that are extracted from a surgically-resected sample of patient tumor. LN-144 infusion is preceded by a non-myeloablative lymphodepletion regimen of cyclophosphamide and fludarabine and followed by IL-2 for up to 6 doses. Patients ≥ 18 years of age must have progressive, unresectable metastatic melanoma (Stage IIIc or Stage IV) following ≥1 line of prior systemic therapy including immune checkpoint inhibitors and BRAF-targeted therapy (if BRAF mutation-positive). A minimum of 2 tumor lesions are required: 1 for resection and TIL manufacture and 1 for assessment of response by RECIST 1.1 criteria. Other major eligibility criteria include: adequate bone marrow, cardiac, liver, pulmonary, and renal function; ECOG PS of 0 or 1. Efficacy is being assessed as a function of ORR, CR rate, DOR, DCR, and PFS per RECIST 1.1 and OS. Assessment of safety data will be descriptive and based on the summarization of TEAEs, SAEs, AEs leading to discontinuation from treatment and the study, vital signs, physical examinations, and clinical laboratory tests. Citation Format: Amod Sarnaik, Brendan Curti, Diwakar Davar, Omid Hamid, Jose Lutzky, Melissa Wilson, Harriet Kluger, Jason Chesney, Kevin Kim, Giao Phan, Sajeve Thomas, Eric Whitman, Bente Larsen, Sam Suzuki, Nancy Samberg, Igor Gorbatchevsky, Maria Fardis, John M. Kirkwood. A phase II, multicenter study to assess the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-144) for treatment of patients with metastatic melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr CT169
- …
