161 research outputs found
Analysis of dimensional performance for a 3-D open-source printer based in FDM technique
No full textIn this paper an analytical dimensional performance evaluation and comparison is illustrated, done on benchmarks manufactured using two different 3D FDM printers: an industrial system, and an open source one (a modified Fab@Home Model 1 printer).
Using a factorial analysis design of experiment (DOE), optimum process parameters were found to improve dimensional accuracy on rectangular test specimens, minimizing changes in length, width and height. Fab@Home printer demonstrated to be a good platform, simple, flexible and inexpensive
Argumentative essay: Appearance discrimination in politics
No full textThe purpose of the research paper is to inform the reader of the impact a political candidate’s appearance has on his or her electoral success. The author cites sources that confirm role-independent traits (appearance, personality, other non-political traits) play a more crucial role in people’s voting decisions compared to the role-relevant traits (experience, political record, proposed plans) of politicians. The research paper cites evidence that proves role-independent traits are more important to voters by referencing research that explains how quickly individuals subconsciously identify the winner of an election after watching 10-second silent clips by observing candidate body language. The race and gender of politicians also influences the perceptions of voters, as voters have been proven to identify and relate different characteristics to different races and genders while other factors are held constant. Research also proves that certain appearance features like babyface and posture can either benefit or harm certain candidates depending on the circumstances. Finally, various media outlets like Facebook and YouTube influence people’s perceptions about political candidates in different ways. In conclusion, appearance discrimination in politics is a very complex topic, and it takes place in several different ways. Not much research has been done on why this takes place, but there is enough evidence in previous research that allows the author of this paper to conclude that people do vote for political candidates based their respective appearances. (Author abstract)Bodi, E. (2014). Appearance discrimination in politics. Retrieved from http://academicarchive.snhu.ed
Handbook on naturalization law, with Yiddish translation; being a summary of questions and answers, also giving the form of the United States government, by Athanas Themel Bodi.
No full text54, [2] p
KESESUAIAN SARANA PRAKTIKUM PROGRAM KEAHLIAN TEKNIK BODI OTOMOTIF DI SMK DENGAN BENGKEL BODY REPAIR
No full textSarana praktikum merupakan salah satu faktor untuk menyelenggarakan pendidikan. Sekolah menengah kejuruan merupakan tingkat pendidikan yang fokus pembelajarannya lebih banyak kepada kegiatan praktik, maka untuk menyelenggarakan pendidikannya SMK harus memiliki sarana berupa peralatan dan bahan praktikum yang lengkap dan sesuai dengan industri atau bengkel. Tujuan penelitian ini untuk mengetahui kesesuaian sarana praktikum pada program keahlian teknik bodi otomotif di sekolah menengah kejuruan dengan bengkel body repair. Penelitian ini dilatar belakangi saat melaksanakan Program Pengalaman Lapangan pada program keahlian teknik bodi otomotif di SMKN 8 Bandung. Penulis menemukan kendala ketika akan mengajar di workshop bodi otomotif, penulis harus meminjam alat ke workshop jurusan lain. Metode penelitian yang digunakan yaitu mix method dengan pendekatan deskriptif. Sampel dalam penelitian ini adalah workshop teknik bodi otomotif. Teknik pengumpulan data yang digunakan yaitu teknik wawancara, observasi, angket, dan dokumentasi. Teknik analisis data yang dilakukan dalam penelitian ini menggunakan triangulasi data dan statistik deskriptif. Hasil penelitian menunjukan bahwa kesesuaian sarana praktikum berupa peralatan prakikum menunjukan skala persentase sebesar 92% yang berarti pencapaian kriteria interpretasi skor sudah dikatan sangat layak, dan kesesuaian sarana praktikum berupa bahan praktikum menunjukan skala persentase sebesar 93% yang berarti pencapaian kriteria interpretasi skor sudah dikatan sangat layak.
The practice tool is one of the factors for administering education. Vocational high school is the level of education that focuses more education on practice activity, Therefore to administering education vocational high school must have the necessary tools and practical materials available to a specific industry or workshop. The purpose of this study is to establish the appropriateness of the development of automotive engineering programs in a vocational school with body repair workshop. This research was set back when implementing a field experience program on automotive engineering programs in vocational high school of 8 Bandung. The author found the constraint when going to teach at automotive workshops, the author needs to borrow tools to a major's workshop. The method of research used is that mix method with a descriptive approach. The sample in this study is a automotive engineering workshop. The data-collection techniques used are interviews, observations, questionnaire, and documentation. The techniques for data analysis done in this study use data tringulation and descriptive statistics. Research results show that practical tools of practice in practical instruments demonstrate a 92% percentage scale, which means that the attainment of rating criteria is very reasonable, And the appropriateness of the precurative material of practical material shows a 93% percentage scale, which means that the attainment of value-definition criteria is highly feasible
Subway and its powerful presence in social media
No full text“Analyzing Subway’s Successful Social Media Efforts” is a required project for the social media and marketing communications course. This project, which began during the fall semester of 2014, involves identifying Subway’s varying advertisement campaigns, the main target market these ads are intended for, the main media vehicles used to deliver these ads, and how effective these ads are in expanding Subway’s global footprint. More specifically, the research paper uncovers Subway’s varying advertisement campaign themes, multiple execution styles, and how Subway successfully applies the dual adaptation strategy in global markets through the use of social media formats Facebook and Twitter. The research also highlights the company’s history, main competitor, product lines and assortment, and its recent financial success. The paper concludes that Doctor’s Association’s Subway brand is highly successful in marketing its products due to its ability to relate the themes of health and fitness with its submarine sandwiches in ads that vary in both execution style and in media format based on the respective audience the company is trying to target. (Author abstract)Bodi, E. (2015). Analyzing Subway’s successful social media efforts. Retrieved from http://academicarchive.snhu.ed
Motorized low-cost 3D structured light scanning system for reverse engineering
No full textRecently, development in the 3D technology is becoming more evident. The diffusion of the acquisition systems is helped from the rapid evaluation of the information technology and Mechatronics, permitting low-cost system by using off-the-shelf hardware (webcam, projectors, etc.) for 3D scanning. This paper is focused on the development, implementation and testing of an automated low cost motorized active 3D structured light scanning system (SLS). The scanner is based on the software platform of the DAVID Laser Scanner Vision Systems GmbH’s. Advanced of basic technologies for comparing the scanned data, will show the differences in performance of the 3D data acquisition with a test to reference approach with a commercial scanning system
From calcium entry blockers to ryanodine receptors: a new therapeutic target in heart diseases.
No full textEven if, calcium entry blockers were introduced many years ago in the treatment of cardiovascular disorders such as hypertension, atrial arrhythmia, and angina pectoris, they still remain key drugs. At present, isoform tissue -selective L-type calcium channel (LTCC) modulators might extend their pharmacotherapeutic potential as well as their established use in cardiovascular diseases. In particular, negative inotropic selective compounds could be useful in the treatment of hypertrophic obstructive cardiomyopathy (HOCM), otherwise known as idiopathic hypertrophic subaortic stenosis. In addition, compounds that can directly modulate RyR2 (ryanodine receptor type 2) or indirectly through voltage-gated calcium channels, are claimed as a new therapeutic approach to heart failure and lethal arrhythmia. With the aim to improve and mapping the ligand site of diltiazem and benzothiazepines to the α1 pore forming subunit of L-type calcium channel, we discovered a series of thiazinoxadiazolone derivatives structurally related to diltiazem (fig. 1) with selective negative inotropic activity. Recently we have applied a multidisciplinary approach based on a virtual screening procedure to discover novel and cardioselective compounds able to bind the benzothiazepine site in the LTCCs. Three novel chemotypes were characterized as LTCC blockers: different forms of the benzosulfonamide scaffold, the 3-phenyl-4-isoxazolecarboxylate and, the 4-phenyl-thiomorpholine-3,5-dione. Compound M8, that is [(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine (fig. 1), was considered the most interesting compound for its negative inotropic effect and vasorelaxant properties. First, M8 was studied as racemate, then the two enantiomers were separated to evaluate their own biological proprieties. As expected, the functional profile observed for the two enantiomers was significantly different. Both the enantiomers have negative inotropic activity in the guinea-pig left atria, R-(+) being twice more potent than S-(–). On the contrary, the vasorelaxing properties tested in guinea pig aortic strips 80 mM K+-depolarized, is uniquely shown by S-(–)-M8, with a potency comparable to (±)-M8. No variation in activity between the two enantiomers was found in binding studies in rat cardiomyocytes and patch-clamp experiments in isolated myocytes from rat tail artery. Such different behavior suggested us an additional mechanism of action for the S-(–)-M8 enatiomer possessing vasorelaxant effect. To verify this hypothesis we began a series of experiments on guinea-pig aortic strips. In this model both (±)-M8 and the two enantiomers did not modify the concentration-response curve to noradrenalin in guinea-pig aortic strips. Otherwise, only S-(–)-M8 inhibited the aortic strip contraction evoked by noradrenalin in absence of extracellular Ca2+. These preliminary findings confirmed that S-(–)-M8 does not interfere with adrenergic receptors and, might exploit its vasorelaxat activity through the modulation of the intracellular Ca2+ release. This latter phenomenon is probably due to the opening of RyRs in the sarcoplasmic reticulum. Voltage-clamp and Ca2+ transient experiments indicate that (±)-M8 interferes with the intracellular Ca2+ handling probably owing to its activity at LTCC level that are coupled to RyRs. As above mentioned, it is well established that RyR2 leakage in cardyomyocites is the main cause of heart failure and lethal arrhythmia, consequently the compounds able to modulate RyRs prevent the intracellular Ca2+ leak and arrhythmias
Modulazione delle correnti ioniche nei canali del calcio di tipo-L (CaV1.2) nativi e clonati di un analogo funzionale del Diltiazem.
No full textOBIETTIVO: il nostro gruppo di ricerca basandosi su un approccio di tipo multidisciplinare ha scoperto recentemente un nuovo calciomodulatore analogo funzionale del diltiazem con struttura fenilsulfonilpirrolidinica (M8). L’ obiettivo di questo studio è la valutazione dell’attività di M8 e dei suoi enantiomeri sulle correnti ioniche, la cinetica dei canali Cav1.2 e sugli effetti del rilascio del Ca2+ intracellulare. MATERIALI E METODI: le correnti del (ICa) o Ba2+ (IBa) nei canali Cav1.2 sono state registrate mediante patch-clamp e voltage-clamp rispettivamente in miociti di arteria caudale di ratto e cardiomiociti di topo, e in oociti di Xenopus che esprimono la variante cardiaca umana dei Cav1.2. L’attività vasorilassante, inotropa negativa e la modulazione del rilascio del Ca2+ intracellulare è stata determinata in vitro su tessuti isolati di cavia. RISULTATI: studi di binding precedenti avevano dimostrato che M8 spiazza [3H]-diltiazem dal proprio sito di legame in cardiomiociti di ratto. Studi di patch-clamp eseguiti su miociti di arteria caudale di ratto hanno evidenziato che M8 riduce la ICa e accelera la cinetica di inattivazione del canale. In cardiomiociti di topo M8 non ha effetti sulla intensità della ICa, allo stesso modo nel voltage-clamp su canali Cav1.2 cardiaci umani, M8 e diltiazem mostrano una trascurabile inibizione della IBa. In tutti gli esperimenti M8 accelera la cinetica di inattivazione del canale e perde il caratteristico use-dependence phenomenon del diltiazem. Su tessuti isolati di cavia i due enantiomeri hanno mostrato una diversa attività: solo uno di essi è responsabile dell’azione vasorilassante posseduta dal racemo mentre entrambi inibiscono la forza di contrazione cardiaca. Esperimenti condotti impiegando strips di aorta di cavia hanno mostrato che solo l’enantiomero dotato dell’attività vasorilassante inibisce il rilascio del Ca2+ dal reticolo sarcoplasmatico indotto da noradrenalina in assenza di Ca2+ extracellulare. CONCLUSIONI: gli studi di patch e voltage-clamp hanno evidenziato che questo nuovo calciomodulatore blocca i canali Cav1.2 preferenzialmente nel loro stato aperto. La perdita dello use-dependence phenomenon potrebbe essere associata alla rapida dissociazione del composto dal sito di legame delle benzotiazepine. Infine uno dei suoi enantiomeri sembra inibire il rilascio di Ca2+ intracellulare con un meccanismo imputabile al blocco del recettore della ryanodina
The development and validation of a multidimensional measure of male body dissatisfaction and its preliminary use in exploring the relationship between body dissatisfaction and exercise
No full textHistorically, research has focused predominately on female experience of body dissatisfaction (BD). More recently there has been an increased focus upon BD in men. The current literature review indicates that research in BD in men is its infancy compared to BD in females and the review highlights the differences between the experience of BD in men and women and the difficulties in applying evidence that has been found in female samples to males. In line with this, tools used to assess females may not be appropriate to assess males. It is therefore important to develop an instrument that accurately assesses BD in males to identify those who may be at risk. The literature review also pays attention to the coping strategies that men may engage in with a particular focus on exercise and its potential role as both a protective and risk factor.The purpose of the empirical paper was to explore the structure of a new measure: The Male Body Dissatisfaction Inventory (M-BoDI). A Principal Components Analysis revealed a four-component structure. The study provided evidence of concurrent validity for the M-BoDI and good internal reliability and the scores on the M-BoDI were stable over a 4-week period. A significant relationship was found between negative reasons for exercising and BD as measured by the M-BoDI, and negative reasons for exercising were also linked to core excessive exercise features. Implications of the current findings and ideas for further research are discussed
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